Infection-Induced Thrombocytopenia

Wilson, Jonathan; Neame, Peter B.; Kelton, John G.

doi:10.1055/s-2007-1005053

Cited by 83 publications

(49 citation statements)

References 140 publications

(217 reference statements)

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“…4 Several studies have shown that arboviral infections like dengue fever, chickugunya, kyasanur forest diseases and scrub typhus and leptospirosis and malaria, military tuberculosis typhoid and Human immunodeficiency causes fever and thrombocytopenia. 5,6 There is seasonal variation in the epidemic of fever. At times non-infective causes and drugs can also cause thrombocytopenia and fever.…”

Section: Introductionmentioning

confidence: 99%

Study of acute febrile illness with thrombocytopenia in a tertiary care centre

Fawas¹,

Beevi²,

Valliyot³

et al. 2018

Int J Res Med Sci

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Background: In the recent period there is an upsurge in the incidence of fever with thrombocytopenia in the Northern Kerala. This may be due to the several emerging and re emerging infections which causes frequent epidemics in the region. Early diagnosis and meticulous management will prevent fatal out come. Studies on fever with thrombocytopenia are very few in the Northern part of Kerala.Methods: This was a descriptive study conducted at Academy of Medical Sciences Pariyaram over a period of one year from November 2015 to October 2016. The study includes 251 cases attending outpatient and inpatients units in the department of medicine. All patients with a platelet count less than 150000 was included in this study and detailed clinical and laboratory evaluation was done and assessed for the etiology and outcome.Results: Among the 251 cases, Dengue fever accounts 54.5 % of cases and 26.2% are other viral fever where the exact causative organism was not detected. Leptospirosis, malaria were also important causes of fever with thrombocytopenia. Major incidence of hemorrhagic manifestation occurred in the age group of 20 to 30 years whose platelet count was in the range of 10000 to 40000/mm3.Conclusions: In this study more than 50 % had dengue fever and in 26.2% cases an exact etiology cannot be determined. This finding highlights the fact that there may be many unidentified infection which cause fulminant thrombocytopenia and there is a need for wider screening of infection.

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Section: Introductionmentioning

confidence: 99%

Study of acute febrile illness with thrombocytopenia in a tertiary care centre

Fawas¹,

Beevi²,

Valliyot³

et al. 2018

Int J Res Med Sci

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“…Hemophagocytosis is prevalent among patients with sepsis, occurring in up to 78% of cases [13] and may also contribute to thrombocytopenia [14,15]. In addition, decreased platelet production has been associated with sepsis; bone marrow hypocellularity and decreased megakaryocytes have been observed in occasional patients [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Cardiobacterium hominis endocarditis associated with very severe thrombocytopenia and platelet autoantibodies

et al. 2004

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Severe thrombocytopenia is a life-threatening condition. It is often associated with immune-mediated platelet destruction or myeloablative chemotherapy. Infective endocarditis has been associated with thrombocytopenia, which, as in sepsis, tends to be mild and is often the result of several pathological mechanisms. We report a case of Cardiobacterium hominis endocarditis associated with very severe thrombocytopenia and bleeding in a patient who refused platelet transfusion. Platelet autoantibodies directed against glycoprotein (Gp) IIb/IIIa and Gp Ib/IX were detected during active infection using a glycoprotein-specific assay. Successful treatment of C. hominis endocarditis was associated with loss of platelet autoantibodies and recovery of the platelet count. This report illustrates that the development of platelet autoantibodies can contribute to very severe thrombocytopenia in occasional patients with infective endocarditis. Am.

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“…Por todo esto, su presentación puede ser impredecible y su incidencia difícil de estimar. Sin embargo, en algunas enfermedades, como el dengue, la trombocitopenia es un signo de importancia clínica y un criterio para clasificar la gravedad de la enfermedad (1)(2)(3)(4).…”

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“…Este último mecanismo puede originarse, ya sea, por daño de las plaquetas debido a la acción directa del virus, por depósito inespecífico de complejos inmunes sobre la superficie de las plaquetas circulantes, que conduce a su opsonización y lisis por el sistema reticuloendotelial, o por destrucción mediada por anticuerpos antiplaquetarios (1)(2)(3)(4)(5).…”

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“…Es, entonces, cuando se reconoce y se documenta la naturaleza autoinmune de esta alteración, en la que se observa destrucción excesiva de las plaquetas mediada por autoanticuerpos contra antígenos presentes en la superficie plaquetaria, que inducen la eliminación de las plaquetas por los macrófagos del hígado y del bazo, contribuyendo así a la trombocitopenia (2,6,10).…”

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Papel de los anticuerpos antiplaquetarios en la infección viral: una revisión sistemática de la literatura

et al. 2011

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Introducción. La trombocitopenia es un fenómeno frecuente en las infecciones virales. Uno de los mecanismos propuesto como posible explicación de su desarrollo es la destrucción plaquetaria periférica mediada por anticuerpos antiplaquetarios. Objetivo. Revisar los resultados de los trabajos originales que existen en la literatura sobre infección viral y anticuerpos antiplaquetarios en humanos, y su efecto sobre el recuento total de plaquetas. Materiales y métodos. Se hizo una búsqueda en PubMed empleando la combinación de términos: "viral infection (OR Virus diseases) AND antibody antiplatelet (OR thrombocytopenia); y antibody antiplatelet AND HIV (OR Measles, OR Dengue, OR Chickenpox OR varicella, OR Epstein Barr, OR Mumps, OR Rubella". Se obtuvieron 218 referencias, de las cuales, 65 correspondían al objetivo de la revisión. Resultados. En la búsqueda se encontró que la trombocitopenia mediada por anticuerpos antiplaquetarios se ha documentado en infecciones virales por VIH, sarampión, dengue, varicelazóster, Epstein-Barr, parotiditis y rubéola. La presencia de anticuerpos antiplaquetarios en infecciones virales por VIH, virus de Epstein-Barr y dengue, se ha asociado con la presencia de la trombocitopenia y con la gravedad de la enfermedad. Conclusiones. Aunque la aparición de anticuerpos antiplaquetarios no se considera el único mecanismo que explica la trombocitopenia desarrollada en las infecciones virales mencionadas, de acuerdo con la literatura científica disponible, su presencia se asocia con la gravedad de la trombocitopenia y con potenciales implicaciones clínicas en los pacientes.Palabras clave: virosis, anticuerpos, plaquetas, trombocitopenia, humanos. Roll of antibodies antiplatelets in viral infection: a systematic review of literatureIntroduction. Thrombocytopenia is a frequent phenomenon in viral infections. Peripheral platelet destruction mediated by anti-platelet antibodies has been one of the proposed causal mechanisms. Objective. Results were collected and analyzed from published studies on associations of human viral infections on anti-platelet antibodies and total platelet counts. Materials and methods. A PubMed search was conducted using the following terms: Viral infection (OR Virus diseases) AND antiplatelet antibody (OR thrombocytopenia) AND HIV (OR measles OR dengue OR chickenpox OR varicella OR Epistein Barr OR mumps OR rubella). Two hundred eighteen reference hits were obtained, 65 of which were relevant to this review. Results. Antiplatelet antibody-mediated thrombocytopenia has been documented in cases of HIV, measles, dengue, chickenpox, Epstein-Barr, mumps and rubella. Moreover, the presence of these antibodies has been associated with severity the disease and thrombocytopenia in viral infections. Conclusions. Although the presence of antiplatelet antibodies was not the only mechanism for explaining the thrombocytopenia developed in these viral infections, their presence was associated with severity of thrombocytopenia and with the clinical presentation of these patients.

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Infection-Induced Thrombocytopenia

Cited by 83 publications

References 140 publications

Study of acute febrile illness with thrombocytopenia in a tertiary care centre

Study of acute febrile illness with thrombocytopenia in a tertiary care centre

Cardiobacterium hominis endocarditis associated with very severe thrombocytopenia and platelet autoantibodies

Papel de los anticuerpos antiplaquetarios en la infección viral: una revisión sistemática de la literatura

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