Infection-induced wheezing in young children

Beigelman, Avraham; Bacharier, Leonard B.

doi:10.1016/j.jaci.2013.12.001

Cited by 19 publications

(23 citation statements)

References 30 publications

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“…Wheezing in early childhood is very common, with 50% of children from high‐income countries (HIC) reported to have experienced an episode of wheezing before 6 years of age . Wheezing illness comprises a spectrum of disease, ranging from transient to recurrent, a proportion of which is associated with asthma . Asthma is the most common chronic illness in children, and particularly high in Africa; thus, it is important to understand the risk factors associated with wheeze onset .…”

Section: Introductionmentioning

confidence: 99%

Associations between maternal mental health and early child wheezing in a South African birth cohort

MacGinty

Lesosky

Barnett

et al. 2018

Pediatric Pulmonology

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BackgroundWheezing in early childhood is common and has been identified in high‐income countries (HIC) as associated with maternal antenatal or postnatal psychosocial risk factors. However, the association between maternal mental health and childhood wheezing has not been well studied in low and middle‐income countries (LMIC), such as South Africa.MethodsA total of 1137 pregnant women over 18 year old, between 20 and 28 weeks’ gestation, and attending either of two catchment area clinics were enrolled in a South African parent study, the Drakenstein Child Health Study (DCHS). Psychosocial risk factors including maternal depression, psychological distress, early adversity, and intimate partner violence (IPV), were measured antenatally and postnatally by validated questionnaires. Two outcomes were evaluated: Presence of wheeze (at least one episode of child wheeze during the first 2 years of life); and recurrent wheeze (two or more episodes of wheezing in a 12‐month period). Logistic regression was used to investigate the association between antenatal or postnatal psychosocial risk factors and child wheeze, adjusting for clinical and socio‐demographic covariates.ResultsPostnatal psychological distress and IPV were associated with both presence of wheeze (adjusted OR = 2.09, 95%CI: 1.16‐3.77 and 1.63, 95%CI: 1.13‐2.34, respectively), and recurrent child wheeze (adjusted OR = 2.26, 95%CI: 1.06‐4.81 and 2.20, 95%CI: 1.35‐3.61, respectively).ConclusionMaternal postnatal psychological distress and IPV were associated with wheezing in early childhood. Thus, screening and treatment programs to address maternal psychosocial risk factors may be potential strategies to reduce the burden of childhood wheeze in LMICs.

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Section: Introductionmentioning

confidence: 99%

Associations between maternal mental health and early child wheezing in a South African birth cohort

MacGinty

Lesosky

Barnett

et al. 2018

Pediatric Pulmonology

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“…6-8 On the basis of these reports, we hypothesized that the beneficial effects of AZM on the reduction of post-RSV wheeze observed in our proof-of concept trial were associated with airway microbiome changes. The goals of this study were to characterize upper airway microbiome changes following AZM or placebo therapies, and to investigate if these changes are related to the reduction in post-RSV RW.…”

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confidence: 96%

Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze

Zhou

Bacharier

Baty

et al. 2016

Journal of Allergy and Clinical Immunology

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“…Wheezing during early childhood is a common clinical condition, triggered by viral infections in 80%‐90% of episodes . There are plausible biologic mechanisms that could explain the associations between maternal mental health problems and offspring infections.…”

Section: Discussionmentioning

confidence: 99%

Perinatal maternal mental health is associated with both infections and wheezing in early childhood

Rusconi

Gagliardi

Gori

et al. 2019

Pediatric Allergy Immunology

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Background Wheezing and infections are common during infancy, and the role of early‐life exposures in their development is still under investigation. We examined associations between maternal mental health in pregnancy and after delivery and subsequent offspring wheezing and infections. Methods We studied 2314 mother‐child pairs recruited in the Piccolipiù birth cohort (Italy) from 2011 to 2015. Maternal mental health was assessed in pregnancy and 12 months after delivery via the General Health Questionnaire‐12 (GHQ‐12). GHQ‐12 Likert scores were collapsed into low (below the upper tercile) and high (above). Risk ratios (RR) and 95% confidence intervals (CI) between each combination of scores—during pregnancy and 1 year after delivery—and outcomes were computed by log‐binomial regression models. Results High scores both in pregnancy and after delivery, compared with low scores in both periods, were associated with wheezing (RR: 1.35; 95% CI: 1.08, 1.69), recurrent (≥2 episodes) wheezing (1.35; 0.99, 1.83), any and recurrent (≥4 episodes) upper respiratory infections (1.20; 1.04, 1.41, and 1.45; 1.07, 1.97, respectively), lower respiratory infections (1.31; 1.08, 1.61), and diarrhea (1.49; 1.23, 1.80). High scores either during pregnancy or 1 year after delivery only were less consistently associated with outcomes. Conclusions Maternal mental health problems extending from pregnancy to the first year after delivery are associated with development of both wheezing and infections. As wheezing is mostly triggered by infections, increased infection susceptibility could represent a possible common biologic mechanism. This study confirms the importance of early‐life exposures on childhood health.

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Infection-induced wheezing in young children

Cited by 19 publications

References 30 publications

Associations between maternal mental health and early child wheezing in a South African birth cohort

Associations between maternal mental health and early child wheezing in a South African birth cohort

Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze

Perinatal maternal mental health is associated with both infections and wheezing in early childhood

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