Infection-iron interaction during COVID-19 pandemic: Time to re-design iron supplementation programs

Augustine, Little Flower; Mullapudi, Vydehi; Subramanian, Sadhana; Kulkarni, Bharati

doi:10.1016/j.mehy.2020.110173

Cited by 9 publications

(8 citation statements)

References 4 publications

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“…Evidence in the context of SARS-CoV-1 and MERS-CoV suggests that iron is important for viral replication ( Liu et al, 2020 ). According to Augustine et al (2020) , oral iron supplementation in the presence of inflammation might lead to enhanced oxidative stress and adverse gut microbiome. This, together with the hypothesis that iron chelators could be considered as adjuvants to treat COVID-19 ( Liu et al, 2020 ; Habib et al, 2021 ), led these authors to be concerned about the safety and effectiveness of iron supplementation programs during COVID-19 pandemic ( Augustine et al, 2020 ).…”

Section: Essential Trace Elements and Covid-19mentioning

confidence: 99%

“…According to Augustine et al (2020) , oral iron supplementation in the presence of inflammation might lead to enhanced oxidative stress and adverse gut microbiome. This, together with the hypothesis that iron chelators could be considered as adjuvants to treat COVID-19 ( Liu et al, 2020 ; Habib et al, 2021 ), led these authors to be concerned about the safety and effectiveness of iron supplementation programs during COVID-19 pandemic ( Augustine et al, 2020 ). On the other hand, various manifestations of COVID-19, such as inflammation, hypercoagulation, hyperferritinemia, as well as immune dysfunction, are also reminiscent of iron overload.…”

Section: Essential Trace Elements and Covid-19mentioning

confidence: 99%

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The effects of some essential and toxic metals/metalloids in COVID-19: A review

Domingo

Marquès

2021

Food and Chemical Toxicology

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Thousands of studies have been conducted in order to understand in depth the characteristics of the novel coronavirus SARS-CoV-2, its infectivity and ways of transmission, and very especially everything related to the clinical and severity of the COVID-19, as well as the potential treatments. In this sense, the role that essential and toxic metals/metalloids have in the development and course of this disease is being studied. Metals/metalloids such as arsenic, cadmium, lead, mercury or vanadium, are elements with known toxic effects in mammals, while trace elements such as cobalt, copper, iron, manganese, selenium and zinc are considered essential. Given the importance of metals/metalloids in nutrition and human health, the present review was aimed at assessing the relationship between various essential and toxic metals/metalloids and the health outcomes related with the COVID-19. We are in the position to conclude that particular attention must be paid to the load/levels of essential trace elements in COVID-19 patients, mainly zinc and selenium. On the other hand, the exposure to air pollutants in general, and toxic metal/metalloids in particular, should be avoided as much as possible to reduce the possibilities of viral infections, including SARS-CoV-2.

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Section: Essential Trace Elements and Covid-19mentioning

confidence: 99%

Section: Essential Trace Elements and Covid-19mentioning

confidence: 99%

The effects of some essential and toxic metals/metalloids in COVID-19: A review

Domingo

Marquès

2021

Food and Chemical Toxicology

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“…Hyperferritinemia is considered to be a marker of cell damage and, in COVID-19, is associated with severity and in-hospital mortality [41]. Moreover, there are some concerns regarding iron supplementation and COVID-19 exacerbation, as iron plays a pivotal role in virus replication [42]. Therefore, iron-chelating treatment may have a beneficial effect on acquired immunodeficiency syndrome (AIDS) and COVID-19 outcomes [43].…”

Section: Discussionmentioning

confidence: 99%

Post-COVID-19 complications in hospitalized and non-hospitalized patients: the Silesian complications of the COVID-19 (SILCOV-19) database

Niedziela¹,

Głowacki²,

Ochman³

et al. 2022

Polish Archives of Internal Medicine

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This study was designed as a prospective observational registry-based cohort study to compare the scope of early complications in hospitalized and non-hospitalized patients after they have had COVID-19. We showed that abnormal platelet parameters, pulmonary functional and radiological findings, and insomnia were frequent short-term COVID-19 complications in hospitalized and non-hospitalized patients who have had COVID-19.Considering the number of patients who have had COVID-19 worldwide, the high burden of post-COVID-19 complications might be expected.

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“…Although iron supplementation offers immune-boosting benefits in individuals with iron deficiency, it can exacerbate infections and inflammation. Given that iron is important for viral replication, the safety and effectiveness of iron supplementation during the COVID-19 pandemic is controversial[ 35 ].…”

Section: Nutritional Therapy After Renal Transplantationmentioning

confidence: 99%

Medical nutritional therapy for renal transplantation in the COVID-19 pandemic

Akbulut

Gencer-Bingol

2021

WJT

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Nutritional therapy is very important at renal transplantation. Nutrition has become more vital for transplantation patients owing to the coronavirus disease 2019 (COVID-19) pandemic. Inadequate nutrition can negatively affect the immune system. For this reason, adequate protein and energy intake should be provided to the patients. Also, overconsumption of saturated fat, sugar, and refined carbohydrates can both negatively affect the immune system and trigger chronic diseases in transplantation patients. In addition, vitamins and minerals should be monitored and inadequacy should be prevented due to immunomodulatory effects. Applying nutritional therapy suitable for the symptoms of renal transplantation patients and preventing comorbidities may reduce the risk and severity of COVID-19 infection.

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Infection-iron interaction during COVID-19 pandemic: Time to re-design iron supplementation programs

Cited by 9 publications

References 4 publications

The effects of some essential and toxic metals/metalloids in COVID-19: A review

The effects of some essential and toxic metals/metalloids in COVID-19: A review

Post-COVID-19 complications in hospitalized and non-hospitalized patients: the Silesian complications of the COVID-19 (SILCOV-19) database

Medical nutritional therapy for renal transplantation in the COVID-19 pandemic

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