Infection microenvironment-activated core-shell nanoassemblies for photothermal/chemodynamic synergistic wound therapy and multimodal imaging

Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

“…The synthesis of zinc (II)‐based BIF (Zn‐BIF) was based on our previously reported method, with slight modifications. [ 13 b] The resulting PCNSs were obtained by pyrolysis of nanosized Zn‐BIF under an inert atmosphere. The average hydrodynamic diameter of the PCNS was ≈150 nm ( Figure a).…”

“…Zn‐BIF was synthesized according to the previously reported method, with slight modifications. [ 13 b] In brief, a mixture of Zn(NO 3 ) 2 ·6H 2 O (1 mmol), NaBH(2‐mim) 3 (0.35 mmol), 4,4′‐oxybis(benzoic acid) (0.5 mmol), and cetyltrimethylammonium bromide (CTAB) (0.15 mmol) was dissolved into N , N ‐dimethylformamide (3 mL), (±)‐2‐amino‐1‐butanol (1 mL), and acetonitrile (3 mL). The mixed solution was placed in a 10 mL vial and stirred rapidly for 30 min and then maintained at 80 °C for 24 h. After centrifugation (13 000 rpm for 10 min), the as‐prepared Zn‐BIF was washed with methanol for several times, and then collected.…”

“…The η of PCNS was calculated using the methods previously described. [ 13 a] To directly evaluate the capacity of laser/US‐triggered ROS production in vitro, the maximum absorption wavelength of molecular probe DPBF (1000 μg mL −1 ) centered at 425 nm was measured by a UV‐Vis spectrophotometer irradiation with 808 nm NIR laser (1.0 W cm −2 ) and low‐intensity ultrasound (1 MHz, 1.0 W cm −2 ). The 1 O 2 quantum yield ( φ Δ ) was calculated through monitoring the oxidation of DPBF.…”

“…Recently, we showed that metal boron imidazolate framework (M‐BIF) and M‐BIF‐derived porous nanostructures could achieve multimodal anticancer and antibacterial effects such as those shown by PTT, photodynamic therapy, and chemodynamic therapy. [ 13 ] Considering their unique physicochemical properties that may affect biomedical characteristics, BIF‐derived single‐component porous nanostructures are ideal candidates for a synergistic PTT/SDT therapy.…”

Biodegradable Fe(ii)/Fe(iii)-coordination-driven nanoassemblies for chemo/photothermal/chemodynamic synergistic therapy of bacterial infection

“…11 Qi et al synthesized PVP modified Gd-doped Bi 2 S 3 @Cu( ii ) boron imidazolate framework nanoassemblies to eliminate bacteria by PTT/CDT synergistic activity. 12 Zhao et al prepared non-stoichiometric cobalt sulfide nanodots to enhance PTT/CDT therapies against tumors. 13 However, most nanoparticle platforms cannot be biodegraded in vivo , posing potential toxicity to organisms.…”