Infection Models and Imaging Techniques Used in Preclinical Studies

Gültekin, Aziz; Üstün, Funda

doi:10.4274/nts.galenos.2019.0008

nts

2019

DOI: 10.4274/nts.galenos.2019.0008

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Infection Models and Imaging Techniques Used in Preclinical Studies

Aziz Gültekin¹,

Funda Üstün²

Abstract: ÖzYa zış maAd re si/Ad dressforCor res pon den ce

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2021

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Cited by 1 publication

References 24 publications

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Physiological Animal Imaging with 68Ga-Citrate

Uğur

Gültekin

2021

CRP

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: Gallium-68 is an ideal research and hospital-based PET radioisotope. The uptake mechanism of Gallium citrate is a combination of specific and non-specific processes, for example, vasodilatation, increased vascular permeability, plasma transferrin binding and lactoferrin and siderophores. In this study, by applying the 68Ge/68Ga generator product, a simple technique for the synthesis and quality control of 68Ga-citrate was introduced and was followed by preliminary animal studies. The synthesis of 68Ga-citrate was performed with a cationic method using the Scintomics automated synthesis system (Scintomics GmbH GRP module 4V). Since the standard procedure for quality control (QC) was not available, the definition of chemical and radiochemical purity of 68Ga-citrate was carried out according to the ICH Q2(R1) guideline. The standard QC tests were analysed with Scintomics 8100 radio-HPLC system equipped with a radioactivity detector. In this study, a New Zealand rabbit weighing 2520 g was used for PET/CT images. 68Ga-citrate synthesis was performed by a cationic method without using organic solvents. The labelling efficiency was found to be >98%. The HPLC method used to assess the radiochemical purity of 68Ga -citrate was validated as rapid, accurate and reproducible enough to apply it to patients safely. The physiological distribution of 68Ga-citrate was investigated in a healthy rabbit. The blood pool, liver, spleen, kidneys and growth plates were the most common sites of 68Ga-citrate involvement.

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Physiological Animal Imaging with 68Ga-Citrate

Uğur

Gültekin

2021

CRP

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Infection Models and Imaging Techniques Used in Preclinical Studies

Abstract: ÖzYa zış maAd re si/Ad dressforCor res pon den ce

Cited by 1 publication

References 24 publications

Physiological Animal Imaging with 68Ga-Citrate

Physiological Animal Imaging with 68Ga-Citrate

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