Infection of Baboons with Simian/Human Immunodeficiency Viruses

Allan, Jonathan S.; Ray, Pamela; Broussard, Suzanne R.; Whitehead, Evelyn M.; Hubbard, Gene B.; Butler, Thomas; Brasky, Kathleen M.; Luciw, Paul A.; Cheng‐Mayer, Cecilia; Levy, Jay A.; Steimer, Kathelyn S.; Li, John; Sodroski, Joseph; Garcia-Moll, Maria

doi:10.1097/00042560-199509050-00001

Cited by 10 publications

(5 citation statements)

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“…In addition to HBV, baboon cells are also resistant to infection with HIV. 33 A 38‐year‐old male infected with HIV‐1 who failed to respond to triple drug antiretroviral therapy (zidovudine, lamivudine, indinavir) received 600 cGy TBI, cyclophosphamide and baboon BMC (SK Ildstad, unpubl. obs., 1995).…”

Section: Application Of Cross‐species Disease Resistancementioning

confidence: 99%

Xenotransplantation: Application of Disease Resistance

Mueller

Davenport

Ildstad

1999

Clin Exp Pharma Physio

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1. Organ transplantation is now clinically routine for patients with end-stage organ failure. One major limitation in transplantation is chronic rejection involving the loss of the graft despite the use of immunosuppressive agents. Haematopoietic stem cell (HSC) chimerism, achieved through bone marrow transplantation (BMT), induces donor-specific tolerance to transplanted organs and prevents chronic rejection. 2. A second major limitation to organ transplantation is the donor shortage. Xenotransplantation, the transplantation of organs between different species, would have the ability to increase the availability of donor organs. 3. Current immunosuppressive therapies do not prevent the rejection of xenografts. Therefore, the only reliable method for achieving donor-specific tolerance to xenografts may require HSC chimerism. 4. In order to justify the use of BMT to induce transplantation tolerance in patients with non-life-threatening diseases, the morbidity and mortality associated with current conditioning regimens must be addressed. 5. The use of partial conditioning regimens to promote engraftment of xenogeneic HSC and the development of donor-specific tolerance may eventually make xenotransplantation in humans a clinical reality. 6. Additional advantages of xenotransplantation are the ability to genetically engineer the donor xenograft and resistance of some xenografts to infection by human viruses because of the species specificity of most viruses. 7. The clinical application of disease resistance for HIV and hepatitis B virus is the focus of the present review.

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Section: Application Of Cross‐species Disease Resistancementioning

confidence: 99%

Xenotransplantation: Application of Disease Resistance

Mueller

Davenport

Ildstad

1999

Clin Exp Pharma Physio

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“…Prior to the characterization of humans resistant to infection with HIV-1, we implemented a protocol for xenogeneic BMTx (baboon to human) to achieve immune reconstitution in a patient with late-stage AIDS. Baboons are resistant to infection with HIV in vivo and in vitro [60]. A detailed program for screening baboons to prevent possible xenozoonosis by baboon-to-human transplantation was developed prior to implementation of the protocol [61].…”

Section: Species-specific Infectionsmentioning

confidence: 99%

Baboon Bone Marrow Transplantation in Humans: Application of Cross‐Species Disease Resistance

1997

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Xenotransplantation is a newly evolving field. A renewed interest has emerged coincidentally with the shortage of donor organs for transplantation. Bone marrow (BM) chimerism has been suggested as a potential strategy to induce tolerance to xenografts and control the immune response across a species barrier. Bone marrow transplantation (BMTx) displays unique features compared to solid-organ transplantation or transplantation of other cellular grafts. To achieve engraftment of the pluripotent hematopoietic stem cell, which generates all lineages of the hematolymphopoietic system, conditioning of the recipient (usually a combination of irradiation and cytoablative chemotherapy) is required. Once engraftment is achieved, graft function is stable and rejection does not occur, even without immunosuppression. On the other hand, the graft itself is able to generate an immune response against the host, resulting in graft-versus-host disease (GVHD). A newly recognized advantage to xenotransplantation is species-specific disease resistance. In terms of BMTx, important questions arise: Can xenogeneic BM generate a competent immune response across species barriers? Will cross-species GVHD occur? What are the possible applications to humans? This review addresses these questions. Problems emerging from xenogeneic BMTx are summarized and strategies for their solution discussed.

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“…To overcome this, a chimera virus, simian/human immunodeficiency virus (SHIV) was constructed using HIV env, tat, rev and vpu genes on an SIV mac backbone [29]. Previous studies in our laboratory and by other researchers have shown that baboons infected systemically with SHIV show high viraemia with culturable virus from peripheral mononuclear cells (PBMCs) [3, 16, M.G. Otsyula, G.K. Chege and J. Nganga unpublished data].…”

Section: Introductionmentioning

confidence: 99%

“…Otsyula, G.K. Chege and J. Nganga unpublished data]. Experimental infection of baboons with SHIV constructs is, therefore, currently being considered as a potential model for studying HIV-1 pathogenesis and prophylaxis [3]. This project utilized female olive baboons, which had been previously systemically inoculated with SHIV 89.6P strain.…”

Section: Introductionmentioning

confidence: 99%

Effect of menstrual cycle on mucosal immunity to SHIV within the reproductive tract of baboons (Papio anubis): preliminary findings

Ochiel

Wango

Kigondu

et al. 2003

J of Medical Primatology

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The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.

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Infection of Baboons with Simian/Human Immunodeficiency Viruses

Cited by 10 publications

References 0 publications

Xenotransplantation: Application of Disease Resistance

Xenotransplantation: Application of Disease Resistance

Baboon Bone Marrow Transplantation in Humans: Application of Cross‐Species Disease Resistance

Effect of menstrual cycle on mucosal immunity to SHIV within the reproductive tract of baboons (Papio anubis): preliminary findings

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