Infection of the Newborn with Herpesvirus hominis

Nahmias, André J.; Alford, Charles A.; Korones, Sheldon B.

doi:10.1016/s0065-3101(22)00535-7

Cited by 168 publications

(3 citation statements)

References 71 publications

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“…As a result, neonatal herpes, which is transmitted through an infected maternal genital tract, is on the rise. Disease manifestations most often occur between I and 2 weeks of life, but may occur as early as the first day or as late as the first month (49). Disseminated disease with multiple organ involvement (skin, central nervous system (CNS), eye, mouth, viscera) is common and has a mortality rate as high as 80%.…”

Section: Herpes Simplexmentioning

confidence: 99%

General Configuration of Cholestasis in the Newborn

Spivak,

Grand

1983

J. pediatr. gastroenterol. nutr.

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SummaryThe infant with cholestasis presents a series of diagnostic challenges which require careful delineation. Correct diagnosis, permitting selection of appropriate management and therapy, can be made in the vast majority of patients. When the diagnosis remains obscure, exploratory surgery to distinguish intrahepatic from extrahepatic cholestasis should be performed by 60 days of age in order to provide the best possible outcome. Nevertheless, in both intrahepatic and extrahepatic cholestatic disorders, the characteristics of the original insult determine the prognosis, which may often be predicted by the early liver biopsy. When end‐stage liver disease is inevitable, hepatic transplantation may be considered.

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Section: Herpes Simplexmentioning

confidence: 99%

General Configuration of Cholestasis in the Newborn

Spivak,

Grand

1983

J. pediatr. gastroenterol. nutr.

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“…This infection is of importance for two main reasons. Firstly, it is responsible for disseminated herpes virus infection of the newborn, the virus being transmitted to the child during delivery; neonatal herpes carries a high morbidity and mortality (Nahmias et al , 1970). Secondly, there is increasing epidemiological, cytological and biochemical evidence which strongly suggests an association of the infected cervix with the future development of cervical carcinoma (Kessler, 1976; Aurelian, 1976).…”

Section: Introductionmentioning

confidence: 99%

Value of the Erythrocyte Sedimentation Rate in Primary Genital Herpes

Kinghorn

Turner

1978

Int J Clinical Practice

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An elevated erythrocyte sedimentation rate may be a useful indicator of cervical infection in primary genital herpes infections. Mean ESR in 26 patients with both vulval and cervical herpetic lesions showed a highly significant elevation compared to that obtained from 13 patients with vulval herpetic lesions alone (P < 0.00 I) and also to that obtained from 527 female control patients with no clinical abnormality (P < 0.00 I). The ESR should be a routine test in all female patients who are either clinically suspected, or are contacts of genital herpes.

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“…Reinfection with the same strain can occur by autoinoculation at a distant site. Thus, HSV-1 could be mechanically transmitted from one site to another site as it occurs in cases of mouth-togenital transmission (60) or intended inoculation of vesicle fluid ‚bolster immunity‛ (61).…”

Section: Pathology and Pathogenesismentioning

confidence: 99%

Genetic variation of glycoprotein d within herpes simplex virus isolated from clinical specimens

Naemkhunthot

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Herpes simplex virus (HSV) distributing worldwide, belongs to family Herpesviridae, subfamily alphaherpesvirinae. There are 2 serotypes, i.e., HSV-1 and HSV-2. The initial infection starts by using glycoprotein D (gD) contact to host cell surface receptors resulting to viral entry by membrane fusion. Moreover, gD can induce the production of neutralizing antibody. Therefore, mutations of HSV gD are critical for viral growth in cells which might affect cell pathology and pathogenesis of diseases. The objective of this study is to investigate the variations of HSV gD. One hundred samples were selected by using systemic sampling from 256 clinical specimens during the year of 1999 – 2010. Only 70 samples were successfully isolated. They were typed by Real time PCR revealing 37 were HSV-1 and 33 were HSV-2. After that, gD gene was amplified and DNA sequencing. The results were compared to the sequences previously reported in GenBank. From nucleotide sequencing data, HSV-1 gD of 13 patterns were different from HSV-1(KOS) reference strain. While HSV-2 gD showed 9 patterns differed from HSV-2 (HG52) reference strain. Mutation was the major mechanism of variation. Only 6 positions had non-synonymous amino acid changes. After phylogenetic tree was constructed, the variations of HSV-1 gD and HSV-2 gD were distinctively separated. However, intratypic variation was very low. In conclusion, HSV gD from clinical specimens had low variations. HSV-1 gD had more divergent than HSV-2. The major cause of variation was synonymous point mutation. Therefore, HSV gD is a good candidate for vaccine development.

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Infection of the Newborn with Herpesvirus hominis

Cited by 168 publications

References 71 publications

General Configuration of Cholestasis in the Newborn

General Configuration of Cholestasis in the Newborn

Value of the Erythrocyte Sedimentation Rate in Primary Genital Herpes

Genetic variation of glycoprotein d within herpes simplex virus isolated from clinical specimens

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