Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics

Iyer, Parvati; Chino, Takehiro; Ojcius, David M.

doi:10.3389/froh.2022.1001790

Cited by 4 publications

(2 citation statements)

References 91 publications

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“…The choice of swabs to collect samples was based on their ease of use, non-invasiveness, and ability to precisely obtain samples from specific areas in the oral cavity 21 . Regarding alternative collection methodologies, several approaches could have been considered for sampling the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Assessment of species distribution and virulence factors of oral fungal carriage among hospitalized patients with COVID-19: a case–control study

Ramezanalipour,

Hashemi,

Daie Ghazvini

et al. 2024

Annals of Medicine &Amp; Surgery

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Background: The COVID-19 pandemic highlighted the need to study oral fungal carriage and its potential impact. In oral fungal environments, factors like changes in respiratory epithelium, increased pathogen attachment, local inflammation, and virulence factors could influence COVID-19 severity. We conducted a study to explore oral fungal carriage in COVID-19 patients and compare it to a healthy control group. Methods: We executed a case–control investigation including 144 COVID-19 patients and an equivalent number of 144 healthy controls. The matching criteria encompassed age, gender, body mass index, and the history of antibiotic and antiviral medication intake. This research was performed over a span of 12 months from May 2021 to May 2022. The mouth area was sampled with a cotton-tipped swab. Subsequently, all the samples underwent fungal culture and PCR-sequencing procedures. Results: In COVID-19 patients, oral fungal carriage was three times higher compared to healthy controls. Candida was the exclusive genus found in both groups, with Candida albicans being the most frequently isolated species (90.79%). Among COVID-19 patients, Candida species showed significantly higher esterase, proteinase, and hemolysin activity compared to healthy individuals. Both groups exhibited elevated levels of C. albicans virulence factors compared to non-albicans species. Conclusions: It is crucial to understand the way that virulence factors of oral fungal carriage act in COVID-19 patients in order to come up with novel antifungal medications, identify the contributing factors to drug resistance, and manage clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Assessment of species distribution and virulence factors of oral fungal carriage among hospitalized patients with COVID-19: a case–control study

Ramezanalipour,

Hashemi,

Daie Ghazvini

et al. 2024

Annals of Medicine &Amp; Surgery

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“…tissues are among the SARS-CoV-2 targets [148]. Therefore, the initial disease diagnosis will require an important step performed by dental practitioners, which can then be verified further by patient testing [149,150]. For example, ulcerated gingival lesions might represent the ultimate step of SARS-CoV-2 invasion of oral mucosal cells, mostly through the ACE2/TMPRSS2 pathway, which may subsequently impact oral epithelial cells' ability to function [27,140].…”

Section: Oc Pathologies Triggered By Covid-19mentioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.

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Screening Commercial Tea for Rapid Inactivation of Infectious SARS-CoV-2 in Saliva

Morris,

Esseili

2024

Food Environ Virol

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Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics

Cited by 4 publications

References 91 publications

Assessment of species distribution and virulence factors of oral fungal carriage among hospitalized patients with COVID-19: a case–control study

Assessment of species distribution and virulence factors of oral fungal carriage among hospitalized patients with COVID-19: a case–control study

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Screening Commercial Tea for Rapid Inactivation of Infectious SARS-CoV-2 in Saliva

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