Infection-provoked reversible posterior leukoencephalopathy syndrome in an adult with nephrotic syndrome: a case report

Li, Kuan‐Ying; Chien, Ching-Fang; Tsai, Chin-Ling; Chen, Huang‐Chi; Wu, Meng‐Ni; Lai, Chiou-Lian; Liou, Li-Min

doi:10.1186/s12883-020-01922-x

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…PRES has also not been reported in patients with PD and There are a small number of adult cases showing an association between NS and PRES, as listed in Table (9)(10)(11)(12)(13)(14)(15)(16)(17). It is particularly interesting to consider that NS and PRES may have similar pathogenesis due to endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome and Atypical Posterior Reversible Encephalopathy Syndrome in a Patient with Parkinson's Disease

et al. 2022

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A 59-year-old man with advanced Parkinson's disease treated using levodopa-carbidopa intestinal gel (LCIG) presented with leg edema, hypoalbuminemia, and proteinuria at 1 year after the treatment. He subsequently developed a generalized tonic-clonic seizure, and brain magnetic resonance imaging indicated vasogenic edema in the white matter of the left frontal subcortex. He was diagnosed with nephrotic syndrome (NS) and atypical posterior reversible encephalopathy syndrome (PRES). LCIG cessation and corticosteroid treatment improved the NS. To our knowledge, this is the first case report of NS and atypical PRES in patients with Parkinson's disease. Patients being treated with LCIG should be closely monitored for NS.

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Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome and Atypical Posterior Reversible Encephalopathy Syndrome in a Patient with Parkinson's Disease

et al. 2022

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“…Studies have shown that, in 70% of patients, the onset of RPLS was preceded by acute hypertension as well as infections. [ 15 , 16 ] Our patient was a known hypertensive patient with obstructive ureteric calculus superimposed with infections. Her hypertension was adequately controlled although it was high at time of admission.…”

Section: Discussionmentioning

confidence: 99%

Obstructive ureteric calculus with superimposed infections causing reversible posterior leukoencephalopathy syndrome

Xie¹,

Cai²,

Huang

et al. 2021

Medicine

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Rationale: Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinicoradiological phenomenon first observed 2 decades ago. Reversibility is the hallmark of this rare clinical phenomenon once the triggering pathology is aptly and adequately treated. Tinnitus preceding bilateral hearing loss as a symptomatology of RPLS has not been reported in the literature. Furthermore, chronic obstructive ureteric calculus with superimposed infections as a cause of RPLS has not been reported in the literature. Patient concerns: A 57-year-old female was admitted at our facility because of 2 days history of hearing loss in both ears. She experienced tinnitus in both ears 2 weeks prior to the hearing loss. She is a known hypertensive. She has also undergone multiple surgical treatments for urinary calculi. Diagnosis: Computed tomography (CT) scan of the urinary system revealed a calculus at the right ureter. Magnetic resonance imaging (MRI) showed abnormal signals at both temporo-parieto-occipital (TPO) cortices, the subcortical area, as well as the left hippocampus which was consistent with the diagnosis of RPLS. Interventions: While on antibiotics for treatment of infections, the patient went into hypertensive encephalopathy and pneumonia was also established necessitating intensive care. Outcomes: We observed a resolution of the patient's temperature and hypertension when the right ureteric stone finally descended into the bladder. Also, we observed disappearance of the abnormal signals at both TPO cortices, the subcortical area, as well as the left hippocampus. Two years follow-up revealed no recurrence of her symptomatology. Lesions: Patients who present with hypertensive encephalopathy maybe more prone to developing RPLS. Renal insufficiency alone or hypertension alone may not be single predisposing entities to RPLS but rather multiple predisposing factors.

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Infection-provoked reversible posterior leukoencephalopathy syndrome in an adult with nephrotic syndrome: a case report

Cited by 2 publications

References 6 publications

Nephrotic Syndrome and Atypical Posterior Reversible Encephalopathy Syndrome in a Patient with Parkinson's Disease

Nephrotic Syndrome and Atypical Posterior Reversible Encephalopathy Syndrome in a Patient with Parkinson's Disease

Obstructive ureteric calculus with superimposed infections causing reversible posterior leukoencephalopathy syndrome

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