Infection-related microcephaly after the 2015 and 2016 Zika virus outbreaks in Brazil: a surveillance-based analysis

Oliveira, Wanderson Kleber de; França, Giovanny Vinícius Araújo de; Carmo, Eduardo Hage; Duncan, Bruce Bartholow; Kuchenbecker, Ricardo de Souza; Schmidt, María Inês

doi:10.1016/s0140-6736(17)31368-5

Cited by 272 publications

(280 citation statements)

References 21 publications

Supporting

Mentioning

233

Contrasting

Unclassified

Order By: Relevance

“…It is also tempting to speculate that the 2015/2016 imbalance in reporting may have been a general phenomenon across Brazil. As described elsewhere, it is thus possible that FSA is a good example of states and urban centres that may have witnessed larger epidemics than reported in 2015 (de Oliveira et al, 2017). This, together with our conclusion that low MC risk with very high attack rates makes ZIKV a public health concern, could explain why most MC reports at the level of the country were in 2015 (de Oliveira et al, 2017), although for many regions the total reported number of ZIKV cases may have been surprisingly small that year.…”

Section: Discussionmentioning

confidence: 93%

“…The rise in ZIKV incidence in FSA coincided temporally with an increase in cases of Guillain-Barré syndrome (GBS) and microcephaly (Faria et al, 2016a), with an unprecedented total of 21 confirmed cases of microcephaly in FSA between January 2015 and May 2017. There is wide statistical support for a causal link between ZIKV and severe manifestations such as microcephaly (Rubin et al, 2016; de Araújo et al, 2016; Soares de Araújo et al, 2016; Honein et al, 2017; Brasil et al, 2016; de Oliveira et al, 2017), and the proposed link in 2015 led to the declaration of the South American epidemic as an international public health emergency by the World Health Organization (WHO) in 2016; the response to which has been limited to vector control initiatives and advice to delay pregnancy in the affected countries (WHO, 2016b; WHO, 2016a). With few cohort studies published (Honein et al, 2017; Brasil et al, 2016) and the lack of an established experimental model for ZIKV infection (Aman and Kashanchi, 2016; Dowall et al, 2016), modelling efforts have taken a central role for advancing our understanding of the virus’s epidemiology (Chowell et al, 2016; Ferguson et al, 2016; Bogoch et al, 2016; Nishiura et al, 2016; Zhang et al, 2016; Perkins et al, 2016; Messina et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological and ecological determinants of Zika virus transmission in an urban setting

Lourenço

Lima

Faria

et al. 2017

eLife

View full text Add to dashboard Cite

The Zika virus has emerged as a global public health concern. Its rapid geographic expansion is attributed to the success of Aedes mosquito vectors, but local epidemiological drivers are still poorly understood. Feira de Santana played a pivotal role in the Chikungunya epidemic in Brazil and was one of the first urban centres to report Zika infections. Using a climate-driven transmission model and notified Zika case data, we show that a low observation rate and high vectorial capacity translated into a significant attack rate during the 2015 outbreak, with a subsequent decline in 2016 and fade-out in 2017 due to herd-immunity. We find a potential Zika-related, low risk for microcephaly per pregnancy, but with significant public health impact given high attack rates. The balance between the loss of herd-immunity and viral re-importation will dictate future transmission potential of Zika in this urban setting.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Epidemiological and ecological determinants of Zika virus transmission in an urban setting

Lourenço

Lima

Faria

et al. 2017

eLife

View full text Add to dashboard Cite

show abstract

“…In Brazil, ZIKV was declared a Public Health Emergency after researchers reported an unexpected increase in the diagnosis of fetal and pediatric microcephaly [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study

Aguiar

Cavalcanti

Alencar

et al. 2018

Pesqui. bras. odontopediatria clín. integr.

View full text Add to dashboard Cite

Objective: To analyze the chronology of first deciduous tooth eruption in children with microcephaly associated with presumed or confirmed Zika virus. Material and Methods: A longitudinal study was developed with 74 children of both sexes. Data on prematurity, gestational age (in weeks), anthropometric characteristics at birth [length (cm), weight (g) and cephalic perimeter (cm)] and dental eruption (chronological age and corrected age for prematurity in months) were collected and presented through descriptive statistics. Data was analyzed using the Statistical Package for Social Sciences. Results: The majority of children were female (54.1%) and 14.9% were born premature. The mean gestational age was 38.2 (± 1.9) weeks, while length, weight and cephalic perimeter at birth were 45.6 (± 3.1) cm, 2750 (± 526.6) and 30 (± 2.3) cm, respectively. The eruption of the first tooth occurred on average at 12.3 (± 3.0) months of chronological age and at 11.1 (± 2.3) months of corrected age. The first erupted teeth were the lower deciduous central incisors (82.4%). The mean age for dental eruption in males was 12.5 months (± 3.0) and in females 12.0 months (± 3.1) among full-term children. For premature infants, the mean corrected age of dental eruption was 11.5 months (± 3.4) for boys and 11 months (± 1.7) for girls. Conclusion: In this group of children with microcephaly, the first tooth to erupt was the lower central incisor around the first year of life. Girls had lower average eruption time when compared to boys in both chronological age and age corrected for prematurity.

show abstract

“…As a result of the sudden rise in congenital abnormalities and occurrences of Guillain-Barré syndrome, the scientific community established a causal association between ZIKV infection and these neurological adverse outcomes 7–9 . This led the WHO to declare ZIKV and its suspected link to birth defects 10,11 a Public Health Emergency of International Concern in February 201612.…”

Section: Introductionmentioning

confidence: 99%

Zika virus vaccines

2018

View full text Add to dashboard Cite

The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating consequences of ZIKV infection, particularly in pregnant women. Congenital Zika syndrome, characterized by malformations and microcephaly in neonates as well as developmental challenges in children, highlights the need for the development of a safe and effective vaccine. Multiple vaccine candidates have been developed and have shown promising results in both animal models and phase I clinical trials. However, important challenges remain for clinical development of these vaccines. In this Progress, we discuss recent preclinical studies and lessons learned from first in-human clinical trials with ZIKV vaccines.

show abstract

Infection-related microcephaly after the 2015 and 2016 Zika virus outbreaks in Brazil: a surveillance-based analysis

Abstract: None.

Cited by 272 publications

References 21 publications

Epidemiological and ecological determinants of Zika virus transmission in an urban setting

Epidemiological and ecological determinants of Zika virus transmission in an urban setting

Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study

Zika virus vaccines

Contact Info

Product

Resources

About