Infection risk in sexual contacts of syphilis: A systematic review and meta-analysis

Syphilis

“…12 According to a recent meta-analysis from 2022, the cumulative risk of infection from sexual contact with a person with early syphilis is 32.6%. 50 With regard to contagiousness, the AWMF guideline states that 14 days after completion of therapy, there is a high probability that contagiousness is no longer present. 16 TA B L E 4 Examination in late syphilis.…”

“…If patients do not agree to treatment in such a case, repeated clinical examination and serologic testing must be performed at weeks 0, 6, 12, and 24 after sexual contact 12 . According to a recent meta‐analysis from 2022, the cumulative risk of infection from sexual contact with a person with early syphilis is 32.6% 50 . With regard to contagiousness, the AWMF guideline states that 14 days after completion of therapy, there is a high probability that contagiousness is no longer present 16…”

Syphilis

“…Basierend auf einer rezenten Metaanalyse aus dem Jahr 2022 liegt das kumulative Infektionsrisiko bei Sexualkontakt mit einer an Frühsyphilis erkrankten Person bei 32,6% 50 . Bezüglich der Kontagiosität wird in den AWMF‐Leitlinien festgehalten, dass 14 Tage nach erfolgter Therapie höchstwahrscheinlich keine Kontagiosität mehr besteht 16…”

Treponema pallidum protein Tp0136 promoting MMPs/TIMPs imbalance via PI3K, MAPK and NF-κB signalling pathways in HDVSMCs

“…Syphilis, a sexually transmitted disease, which is chronic and systematic, is caused by Treponema pallidum ( T. pallidum ) [ 1 ]. If left untreated, it can damage the nervous systems and cardiovascular, potentially resulting in debilitation and death [ 2 ].…”