Infection surveillance in cardiac transplantation

Snyder, Michael; Markowitz, Norman; Saravolatz, Louis D.; Price, Joan P.; Çox, Donald C.; Keith, Fraser M.; Magliligan, Donald J.

doi:10.1016/0196-6553(88)90078-8

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…Despite 2 courses of metronidazole therapy, the patient in this study required quinacrine for cure, because of recurrence after transplant. This report underscores the importance of detection and cure before transplantation and immunosuppressive therapy (14). The difficulty in treating giardiasis in an immunocompromised host is also supported by a case report in which a patient with human immunodeficiency virus developed biliary giardiasis, despite metronidazole treatment for Giardia enteritis (15).…”

Section: Discussionmentioning

confidence: 57%

“…To avoid the occurrence of giardiasis following transplantation, some transplant centers prescreen for G. lamblia before transplantation. In one study of asymptomatic patients, 1 of 35 patients, prescreened before cardiac transplantation, had giardiasis detected via stool specimens for ova and parasites . Despite 2 courses of metronidazole therapy, the patient in this study required quinacrine for cure, because of recurrence after transplant.…”

Section: Discussionmentioning

confidence: 80%

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Giardiasis in a hematopoietic stem cell transplant patient

Ajumobi

Daniels

Sostre

et al. 2014

Transplant Infectious Dis

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Giardiasis can mimic diarrhea secondary to mucosal injury from the conditioning therapy prior to hematopoietic stem cell transplant (HSCT), as well as from graft-versus-host disease (GVHD). Herein, we describe the endoscopic diagnosis of giardiasis in a patient 2 months after HSCT for myelodysplastic syndrome. The patient was referred to gastroenterology service for suspected GVHD, but duodenal biopsy results showed Giardia lamblia. He was successfully treated with metronidazole with prompt resolution of all of his gastrointestinal symptoms. This case highlights the need to consider giardiasis in the differential diagnosis of diarrhea in the peri-transplant period.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 80%

Giardiasis in a hematopoietic stem cell transplant patient

Ajumobi

Daniels

Sostre

et al. 2014

Transplant Infectious Dis

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“…These symptoms appear 6 to 15 days after infection. [ 6 ] While extensive data are available in children, [ 7 ] people with human immunodeficiency virus [ 8 ] and solid organ transplant (renal transplant, [ 9 , 10 ] kidney or liver transplant, [ 11 ] heart transplant, [ 12 , 13 ] intestinal transplant, [ 14 ] pancreas-kidney transplantation), [ 15 ] rarely has giardiasis been reported post allo-HSCT in detail. According to our literature review of relevant studies, it can occur either in autologous HSCT [ 16 ] or allo-HSCT, [ 1 , 18 ] children [ 16 , 18 ] or adults, [ 17 ] peri-transplantation period [ 19 ] or post-transplantation, [ 19 , 20 ] asymptomatic [ 20 ] or symptomatic.…”

Section: Discussionmentioning

confidence: 99%

Giardia lamblia mimicking acute graft versus host disease after allogeneic hematopoietic stem cell transplantation

Yan

Shi

et al. 2020

Medicine

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Rationale: As the major complications post allogeneic hematopoietic stem cell transplantation (allo-HSCT), gastrointestinal disorders were most commonly ascribed to acute graft-versus-host disease (aGVHD) and opportunistic infections. Though Giardia lamblia ( G lamblia ) is the most common waterborne parasite of intestinal infection worldwide, seldom has it been reported in a patient with acute severe aplastic anemia after allo-HSCT. Patient concerns: A 23-year-old male with severe aplastic anemia developed diarrhea, abdominal cramps, bloating, nausea, vomiting, fever, weight loss, and fatigue after allo-HSCT. Diagnosis: Stool examinations for ova and parasites showed Giardia trophozoites and cysts. Interventions: Methylprednisolone was stopped and the patient was intravenously treated with a 7-day course of metronidazole (500 mg, tid.). Simultaneously, cyclosporine (5 mg/kg) was continually utilized for suspicious gut GVHD. Outcomes: The Giardia lamblia in stool turned negative and his symptoms were resolved after the 7-day course. Lessons: Incorporating non-invasive monitoring of stool examination for ova and parasites in the follow-up algorithm for post-HSCT patients can expedite clinical decision-making in the differential diagnoses for aGVHD even in the non-endemic area. Metronidazole therapy can be well-tolerated in HSCT patients with giardiasis.

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“…In addition, many centers give prophylaxis against Toxoplasma gondii (TOXO) to patients who have not been exposed to this pathogen but have received an allograft from an exposed individual. [2][3][4][5][6][7][8] Typically, screening for exposure is done via detection of IgM and IgG antibodies to TOXO, which is part of the serologic work-up of patients undergoing transplantation. Drugs used for TOXO prevention include pyrimethamine, sulfadiazine and folinic acid.…”

mentioning

confidence: 99%