Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein, interleukin 6, C-reactive protein, white blood cell count, erythrocyte sedimentation rate and body temperature

Klinger, Andreas; Buchfelder, Michael; Schlaffer, Sven; Kremenevskaja, Natalia; Kleindienst, Andrea

doi:10.1007/s00701-013-1875-x

Cited by 5 publications

(11 citation statements)

References 39 publications

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“…8) Klinger et al established normative values for infection surveillance following trans-sphenoidal surgery. 12) In their study, ESR, WBC count, and lipopolysaccharide-binding-protein were affected by the surgery, and they did not offer any advantage. 12) Kuhn et al investigated 75 fusion surgery and spinal instrumentation patients and found that ESR peaked in the first week after surgery in 98% of patients, and it stayed high in the absence of infection in 78% and 53% of patients for the first and third month, respectively.…”

Section: Discussionmentioning

confidence: 89%

“… 12) In their study, ESR, WBC count, and lipopolysaccharide-binding-protein were affected by the surgery, and they did not offer any advantage. 12) Kuhn et al investigated 75 fusion surgery and spinal instrumentation patients and found that ESR peaked in the first week after surgery in 98% of patients, and it stayed high in the absence of infection in 78% and 53% of patients for the first and third month, respectively. 14) An abnormal increase in WBC count during the first postoperative month was observed in 6% of these patients.…”

Section: Discussionmentioning

confidence: 89%

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Spinal Surgery and Subsequent ESR and WBC Changes Pattern: A Single Center Prospective Study

Zare

Sabahi

Safari

et al. 2021

Korean J Neurotrauma

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Objective Postoperative inflammation and infections are common complications of spinal surgery and have similar symptoms. However, postoperative infection may lead to a poor outcome and must be differentiated from postoperative inflammation. The objective of this study is determine the changing pattern of postoperative ESR and WBC counts, and investigate the effects of different variables. Methods A total of 61 patients who underwent spinal surgery were enrolled in this prospective study. The erythrocyte sedimentation rate (ESR) and white blood cell (WBC) counts were measured the day before surgery and on 1st, 3rd, 5th, 7th, and 14th postoperative days. Results WBC counts increased on the 1st postoperative day in comparison with the preoperative day ( p <0.001), and they gradually decreased until the preoperative value was reached on the 14th postoperative day ( p =0.14). The ESR also increased postoperatively, reaching a peak on the 5th postoperative day in comparison with the preoperative day ( p <0.001) and gradually decreased thereafter. However, on the 14th postoperative day, the ESR was significantly greater than the preoperative value ( p <0.001). In addition, a significant positive correlation was observed between ESR and age, duration of surgery, intraoperative blood loss, and duration of anesthesia. Conclusion WBC count continued to rise and was the highest on the 1st postoperative day, after which it gradually decreased and attained normal values on the 14th postoperative day, while the ESR increased on the 1st postoperative day, reached the highest level in patients with and without simultaneous instrumentation on 7th and 5th postoperative days, respectively, and gradually decreased.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

Spinal Surgery and Subsequent ESR and WBC Changes Pattern: A Single Center Prospective Study

Zare

Sabahi

Safari

et al. 2021

Korean J Neurotrauma

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“…Blood biochemical tests are the most easily obtained biological information in postoperative management and can be repeated without the need for invasive lumbar puncture. 23 The baseline of CRP changes after transsphenoidal surgery. 23 CRP increased to a maximum of 2.5 mg/dL the day after surgery and had normalized 1 week later.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Serum C-Reactive Protein and Cerebrospinal Fluid Leakage after Endoscopic Transsphenoidal Surgery

Yamaguchi

Tosaka

Mukada

et al. 2022

J Neurol Surg B Skull Base

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Objective Postoperative cerebrospinal fluid (CSF) leakage in endoscopic transsphenoidal surgery is a potential risk that should be repair. We investigated about the postoperative common hematological examinations for diagnosing postoperative CSF leakage. Methods We retrospectively studied consecutive 214 cases who underwent endoscopic transsellar transsphenoidal approach (ETSA) and an extended endoscopic transsphenoidal approach (E-ETSA). The group in which postoperative CSF leakage occurred was defined as the leak group (group L), and the group in which it did not occur was defined as the non-leak group (group N). Postoperative C-reactive protein (CRP) was compared between the ETSA group and the E-ETSA group, and between the N and L groups. Results The values of white blood cell count and CRP 1-7 days after surgery were significantly higher in the L group. Especially, CRP was clearly elevated in the L group (P<0.001). Even in N group, it was found that the CRP value was higher in the cases of the E-ETSA than the cases of the ETSA (p < 0.001). E-ETSA were excluded, and in the case of ETSA and N group, CRP increased the day after surgery, but decreased gradually thereafter. On the other hand, in the L group, the CRP value tended to increase gradually after surgery. In particular, the CRP on the day before the CSF leak was confirmed was clearly higher than the 5-7th CRP in the N group. Conclusions Elevated CRP after endoscopic endonasal transsphenoidal surgery could be a used as a marker of CSF leakage.

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“…It is known how the inflammatory response, which develops as a response of the host to infections, occurs. Similar inflammatory response may develop after any type of tissue damage such as pancreatitis, major trauma, burns and autoimmune diseases [2][3][4] . General systemic findings of systemic inflammation (SIRS=Systemic Inflammatory Response Syndrome) such as changes in body temperature, leukocytosis, tachycardia may have infectious or noninfectious etiology.…”

Section: Despitementioning

confidence: 99%

Kraniotomi Sonrası Gelişen Enfeksiyon Tanısında Prokalsitoninin C-Reaktif Proteinle Karşılaştırılması

AÇIKALIN¹,

Sezer

TUNA>

2022

JoCASS

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Procalcitonin (PCT) is a glicopeptide of 116 amino acid and precursor of calcitonin hormone. At the present day procalcitonin take attention because of being specific to bacterial infection and also is a new indicator for infection which do not affected from viral infection and Systemic Inflamatuar Response Syndrome. The objective of this study was to show the effect of neurosurgical procedures to procalcitonin levels and to distinguish neurosurgical procedure inflammatory reaction from postsurgical associated infection. We carried out our study in Çukurova University Neurosurgery department between May 2007- December 2007. Total number of 44 intracranial tumor existing patients carried out in the study. One day preoperative and four days postoperative values of procalcitonin, white blood cell, C-reactive protein (CRP) and fever were investigated. Results were analyzed in SPSS 15.0 program. In all infection developing patients of the study procalsitonin levels found over 0.1 ng/ml. According to our results patients with a higher of 0.1 ng/ml procalsitonin values in postoperative second and third need attention to followed carefully for postoperative infection. In our study crp exposed a similar kinetic activity in infection developing and infection free patients. We exposed high levels of crp (CRP>5 ng/ml) in both groups. This predicate that crp can not be used in the following of postoperative infection. We may suggest procalcitonin is superior to other existing infection parameters because of not effecting from surgical associated inflamatuar response and a quicker response to routine used other parameters. We suggest that procalcitonin will be a safe and serious parameter in following neurosurgical associated systemic complications by results of new studies which includes more patients and different surgical procedures.

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Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein, interleukin 6, C-reactive protein, white blood cell count, erythrocyte sedimentation rate and body temperature

Cited by 5 publications

References 39 publications

Spinal Surgery and Subsequent ESR and WBC Changes Pattern: A Single Center Prospective Study

Spinal Surgery and Subsequent ESR and WBC Changes Pattern: A Single Center Prospective Study

Postoperative Serum C-Reactive Protein and Cerebrospinal Fluid Leakage after Endoscopic Transsphenoidal Surgery

Kraniotomi Sonrası Gelişen Enfeksiyon Tanısında Prokalsitoninin C-Reaktif Proteinle Karşılaştırılması

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