Infection with Candida albicans of a Total Knee Arthroplasty

Levine, Michael I.; Rehm, Susan J.; Wilde, Alan H.

doi:10.1097/00003086-198801000-00031

Cited by 52 publications

(22 citation statements)

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“…Based on our results and those reported in the literature [1,4,12,18,19,21,24,28,35,38,39], candidal periprosthetic joint infections are associated with variable outcomes. All of our patients who had successful outcomes were treated with oral antifungal drugs (fluconazole) for a prolonged time, before (mean, 8 months) and after (mean, 2.2 months) prosthesis reimplantation.…”

Section: Resultssupporting

confidence: 74%

“…Most of the published articles on fungal periprosthetic joint infections have been case reports [4,6,9,12,13,16,18,19,21,28,35,37,39]. Owing to the rarity of fungal periprosthetic joint infections, the outcome of this serious complication has not been widely reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

“…Fungal periprosthetic joint infections are a therapeutic challenge. Several different treatment methods, including antifungal drugs [21], débridement with retained prosthesis [4,12,18,28], resection arthroplasty [35,39], and two-stage exchange arthroplasty [1,24,38], have been reported, with variable outcomes.…”

Section: Introductionmentioning

confidence: 99%

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What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection?

Ueng

Lee

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Fungal infection at an arthroplasty site is rare and poses a therapeutic challenge. To the best of our knowledge, no reports have been published thus far on the success rate of prosthesis reimplantation after fungal prosthetic joint infections. Questions/purposes We asked: (1) What is the success rate in terms of infection eradication using a two-stage exchange arthroplasty in patients with hip or knee fungal periprosthetic joint infections, particularly focusing on Candida infections? (2) What patient-, infection-, and treatment-related variables are associated with the success or failure of treatment? Methods From January 2000 to December 2010, 16 patients with hip or knee candidal periprosthetic joint infections were treated with two-stage exchange arthroplasty at our institute. Treatment success was defined as a well-functioning joint without relapse of candidal infection after prosthesis reimplantation, while treatment failure was defined as uncontrolled or relapse of candidal infection or mortality. Variables, including age, sex, comorbidities, microbiology, antimicrobial agents used, and operative methods, were analyzed. Minimum followup was 28 months (mean, 41 months; range, 28-90 months). Results At latest followup, the treatment failed to eradicate the infection in eight of the 16 patients, and there were four deaths related to fungemia. Four patients required permanent resection arthroplasty owing to uncontrolled or recurrent candidal infections. All eight patients (50% successful rate) who had their infections eradicated and successful prosthesis reimplantation had prolonged treatment with oral fluconazole before (mean, 8 months) and after (mean, 2.2 months) prosthesis reimplantation. The antifungal therapy correlated with successful treatment. Renal insufficiency, hypoalbuminemia, anemia, and chronic obstructive pulmonary disease were significantly more prevalent in the treatmentfailure group than in the treatment-success group.

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Section: Resultssupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

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What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection?

Ueng

Lee

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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“…Candida prosthetic arthritis is indeed rare, with only 25 previous cases (MacGregor et al 1979, Goodman et al 1983, Lichtman 1983, Morley and Patterson 1983, Younkin et al 1984, Lim and Stern 1986, Iskander and Khan 1988, Koch 1988, Lambertus et al 1988, Levine et al 1988, Darouiche et al 1989, Evans and Nelson 1990, Paul et al 1992, Tunkel et al 1993, White and Goetz 1995, Cardinal et al 1996 reported in the literature in English. Resection arthroplasty and dkbridement were considered necessary for cure (MacGregor et al 1979, Younkin et al 1984, Lim and Stern 1986.…”

Section: Discussionmentioning

confidence: 99%

Candida arthritis after total knee arthroplasty-a case of successful treatment without prosthesis removal

Fukasawa

Shirakura

1997

Acta Orthopaedica Scandinavica

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“…less functional methods such as arthrodesis or excision arthroplasty. [4][5][6] In this paper, we are describing the two stage revision knee arthroplasty we have performed for a patient with periprosthetic fungal infection due to Candida albicans. We have obtained written and informed consent of the patient.…”

Section: Successful Two Stage Revision For Prosthetic Joint Infectionmentioning

confidence: 99%

Successful Two Stage Revision for Prosthetic Joint Infection Due to Candida albicans : Case Report

Gürsü¹,

Yıldırım²,

Şahin³

et al. 2015

Turkiye Klinikleri J Case Rep

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Infection with Candida albicans of a Total Knee Arthroplasty

Cited by 52 publications

References 0 publications

What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection?

What Is the Success of Treatment of Hip and Knee Candidal Periprosthetic Joint Infection?

Candida arthritis after total knee arthroplasty-a case of successful treatment without prosthesis removal

Successful Two Stage Revision for Prosthetic Joint Infection Due to Candida albicans : Case Report

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