Infection with feline immunodeficiency virus alters intestinal epithelial transport and mucosal immune responses to probiotics

Stoeker, Laura; Overman, Elizabeth L.; Nordone, Shila K.; Moeser, Adam J.; Simões, Rita D.; Dean, Gregg A.

doi:10.1016/j.vetimm.2013.01.017

Cited by 5 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study evaluating 6-week probiotic treatment with E. faecium SF68 (5 Â 10 8 CFU/d) to dogs with chronic naturally acquired subclinical giardiasis did not affect giardial cyst shedding or antigen content and did not alter innate or adaptive immune responses [99]. Administrating a genetically modified L. acidophilus for three days to cats with feline immunodeficiency virus (FIV) suggested the probiotic having an upregulating role in transcellular transport across the gastointestinal ephitelial barrier [100]. There is a recent report in human infants suggesting that specific probiotics or prebiotics may have an impact on human respiratory tract infections caused by rhinoviruses [101].…”

Section: Probiotic Effect On Intestinal Parasites and Virusesmentioning

confidence: 99%

Microbiota and probiotics in canine and feline welfare

et al. 2015

View full text Add to dashboard Cite

Dogs and cats have been cohabiting with us for thousands of years. They are the major human companions. Today, dogs and cats live in urban areas. Cats and most dogs are on high carbohydrate diets and face similar life-style challenges as the human beings. The health and well-being of companion animals, just as their owners, depends on the gut microbes. Providing a proper care and nutritionally balanced diet to companion animals is recognised as a part of our responsibility to maintain the health and well being of our pet. However, as microbiota differences may facilitate exposure to pathogens and harmful environmental influences, it is prudent to search for novel tools to protect dogs and cats and at the same time the human owners from pathogens. Specific probiotic strains and/or their defined combinations may be useful in the canine and feline nutrition, therapy, and care. Probiotic supplementations have been successful in the prevention and treatment of acute gastroenteritis, treatment of IBD, and prevention of allergy in companion animals. New challenges for probiotic applications include maintenance of obesity and overweight, urogenital tract infections, Helicobacter gastritis and parasitic infections. The probiotics of human origin appear to be among the new promising tools for the maintenance of pets' health. However, the host-derived microorganisms might be the most appropriate probiotic source. Therefore, more controlled trials are needed to characterise new and safe probiotic preparations with an impact on general health and well being as well as health maintenance in dogs and cats.

show abstract

Section: Probiotic Effect On Intestinal Parasites and Virusesmentioning

confidence: 99%

Microbiota and probiotics in canine and feline welfare

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This points to a possible antagonistic relationship between lactobacilli and these viruses. Aboubakr et al (2014) have also reported upon the antiviral activity of probiotic LAB against feline calicivirus (Aboubakr et al, 2014) and Stoeker et al (2013) observed improved intestinal homeostasis in cats infected with feline immunodeficiency virus following oral administration of L. acidophilus (Stoeker et al, 2013). These findings all support the antiviral activity of probiotics in cats.…”

Section: Streptomyces Cinnamoneusmentioning

confidence: 70%

Probiotics at War Against Viruses: What Is Missing From the Picture?

et al. 2020

View full text Add to dashboard Cite

Our world is now facing a multitude of novel infectious diseases. Bacterial infections are treated with antibiotics, albeit with increasing difficulty as many of the more common causes of infection have now developed broad spectrum antimicrobial resistance. However, there is now an even greater challenge from both old and new viruses capable of causing respiratory, enteric, and urogenital infections. Reports of viruses resistant to frontline therapeutic drugs are steadily increasing and there is an urgent need to develop novel antiviral agents. Although this all makes sense, it seems rather strange that relatively little attention has been given to the antiviral capabilities of probiotics. Over the years, beneficial strains of lactic acid bacteria (LAB) have been successfully used to treat gastrointestinal, oral, and vaginal infections, and some can also effect a reduction in serum cholesterol levels. Some probiotics prevent gastrointestinal dysbiosis and, by doing so, reduce the risk of developing secondary infections. Other probiotics exhibit anti-tumor and immunomodulating properties, and in some studies, antiviral activities have been reported for probiotic bacteria and/or their metabolites. Unfortunately, the mechanistic basis of the observed beneficial effects of probiotics in countering viral infections is sometimes unclear. Interestingly, in COVID-19 patients, a clear decrease has been observed in cell numbers of Lactobacillus and Bifidobacterium spp., both of which are common sources of intestinal probiotics. The present review, specifically motivated by the need to implement effective new counters to SARS-CoV-2, focusses attention on viruses capable of co-infecting humans and other animals and specifically explores the potential of probiotic bacteria and their metabolites to intervene with the process of virus infection. The goal is to help to provide a more informed background for the planning of future probiotic-based antiviral research.

show abstract

“…We have previously shown that administration of E. hirae to purpose-bred kittens mitigates the increase in intestinal permeability resulting from experimental infection with feline-origin EPEC ( 25 ). Other beneficial mechanisms attributed to E. hirae include free radical scavenging and lipase activity ( 17 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Randomized placebo-controlled trial of feline-origin Enterococcus hirae probiotic effects on preventative health and fecal microbiota composition of fostered shelter kittens

et al. 2022

View full text Add to dashboard Cite

IntroductionDiarrhea is the second most common cause of mortality in shelter kittens. Studies examining prevention strategies in this population are lacking. Probiotics are of particular interest but studies in cats are largely limited to healthy adults or those with induced disease. Only one study in domestic cats describes the use of host-derived bacteria as a probiotic. We previously identified Enterococcus hirae as a dominant species colonizing the small intestinal mucosa in healthy shelter kittens. Oral administration of a probiotic formulation of kitten-origin E. hirae (strain 1002-2) mitigated the increase in intestinal permeability and fecal water loss resulting from experimental enteropathogenic E. coli infection in purpose-bred kittens. Based on these findings, we hypothesized that administration of kitten-origin E. hirae to weaned fostered shelter kittens could provide a measurable preventative health benefit.MethodsWe conducted a randomized, placebo-controlled, blinded clinical trial to determine the impact of a freeze-dried E. hirae probiotic on body weight gain, incidence of diarrhea, carriage of potential diarrheal pathogens, and composition of the intestinal microbiota in weaned fostered shelter kittens.ResultsOne-hundred thirty kittens completed the study. Fifty-eight kittens received the probiotic and 72 received the placebo. There were no significant differences in age, weight upon initiation of the study, number of days in the study, average daily gain in body weight, or weight at completion of the study. Kittens treated with E. hirae were 3.4 times less likely to develop diarrhea compared to kittens treated with placebo (odds ratio = 0.294, 95% CI 0.109–0.792, p = 0.022). A significant impact of E. hirae was not observed on the presence or abundance of 30 different bacterial, viral, protozoal, fungal, algal, and parasitic agents in feces examined by qPCR. With exception to a decrease in Megamonas, administration of the E. hirae probiotic did not alter the predominant bacterial phyla present in feces based on 16S rRNA gene amplicon sequencing.DiscussionDecreased incidence of diarrhea associated with preventative administration of E. hirae to foster kittens supports a rationale for use of E. hirae for disease prevention in this young population at high risk for intestinal disease though additional studies are warranted.

show abstract

Infection with feline immunodeficiency virus alters intestinal epithelial transport and mucosal immune responses to probiotics

Cited by 5 publications

References 31 publications

Microbiota and probiotics in canine and feline welfare

Microbiota and probiotics in canine and feline welfare

Probiotics at War Against Viruses: What Is Missing From the Picture?

Randomized placebo-controlled trial of feline-origin Enterococcus hirae probiotic effects on preventative health and fecal microbiota composition of fostered shelter kittens

Contact Info

Product

Resources

About