Infection with GB virus C/hepatitis G virus among blood donors and hemophiliacs in Martinique, a Caribbean Island

Césaire, Raymond; Martial, Jenny; Maier, H.; Kerob-Bauchet, B.; Béra, Odile; Duchaud, Éric; Brebion, A; Pierre-Louis, Serge J. C.

doi:10.1002/(sici)1096-9071(199910)59:2<160::aid-jmv6>3.0.co;2-y

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…These results are similar to those observed in Australia [13] and other European countries, such as Germany [7,14,15], France [16] and Spain [15], although higher seroprevalences were occasionally reported in Austria [15] and Spain [17]. By contrast, the prevalence of anti-E2 antibodies observed in this study is lower than the frequencies reported in countries in Latin America and Africa [15,18] and higher than the rates observed in some Asian countries [15].…”

Section: Discussionsupporting

confidence: 87%

Antibodies to the E2 Protein of GB Virus C/Hepatitis G Virus: Prevalence and Risk Factors in Different Populations in Italy

et al. 2001

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GBV-C infections are widespread in the general population in Italy and particularly common in risk groups. The different prevalence of GBV-C antibodies detected in third world immigrants is likely to reflect the prevalence in the countries of origin. However, the observation that the length of residency in Italy is a significant risk factor may suggest that at least some GBV-C infections are contracted in Italy.

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Section: Discussionsupporting

confidence: 87%

Antibodies to the E2 Protein of GB Virus C/Hepatitis G Virus: Prevalence and Risk Factors in Different Populations in Italy

et al. 2001

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“…In Shanghai, China, genotype 3 was the most prevalent [55]. In Martinique, Césaire et al, [56], reported genotypes 2a, 1 and 2b among blood donors.…”

Section: Discussionmentioning

confidence: 99%

Frequency and genotypic distribution of GB virus C (GBV-C) among Colombian population with Hepatitis B (HBV) or Hepatitis C (HCV) infection

Alvarado-Mora

Botelho

Nishiya³

et al. 2011

Virol J

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BackgroundGB virus C (GBV-C) is an enveloped positive-sense ssRNA virus belonging to the Flaviviridae family. Studies on the genetic variability of the GBV-C reveals the existence of six genotypes: genotype 1 predominates in West Africa, genotype 2 in Europe and America, genotype 3 in Asia, genotype 4 in Southwest Asia, genotype 5 in South Africa and genotype 6 in Indonesia. The aim of this study was to determine the frequency and genotypic distribution of GBV-C in the Colombian population.MethodsTwo groups were analyzed: i) 408 Colombian blood donors infected with HCV (n = 250) and HBV (n = 158) from Bogotá and ii) 99 indigenous people with HBV infection from Leticia, Amazonas. A fragment of 344 bp from the 5' untranslated region (5' UTR) was amplified by nested RT PCR. Viral sequences were genotyped by phylogenetic analysis using reference sequences from each genotype obtained from GenBank (n = 160). Bayesian phylogenetic analyses were conducted using Markov chain Monte Carlo (MCMC) approach to obtain the MCC tree using BEAST v.1.5.3.ResultsAmong blood donors, from 158 HBsAg positive samples, eight 5.06% (n = 8) were positive for GBV-C and from 250 anti-HCV positive samples, 3.2%(n = 8) were positive for GBV-C. Also, 7.7% (n = 7) GBV-C positive samples were found among indigenous people from Leticia. A phylogenetic analysis revealed the presence of the following GBV-C genotypes among blood donors: 2a (41.6%), 1 (33.3%), 3 (16.6%) and 2b (8.3%). All genotype 1 sequences were found in co-infection with HBV and 4/5 sequences genotype 2a were found in co-infection with HCV. All sequences from indigenous people from Leticia were classified as genotype 3. The presence of GBV-C infection was not correlated with the sex (p = 0.43), age (p = 0.38) or origin (p = 0.17).ConclusionsIt was found a high frequency of GBV-C genotype 1 and 2 in blood donors. The presence of genotype 3 in indigenous population was previously reported from Santa Marta region in Colombia and in native people from Venezuela and Bolivia. This fact may be correlated to the ancient movements of Asian people to South America a long time ago.

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“…In 6 studies , the samples did not include blood donors, 2 studies were carried out on commercial blood donors, and the remaining 3 did not use molecular tests for detecting HPgV‐1. We ended up including 79 studies in the systematic review . The Supplementary content table presents the characteristics of included studies.…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence rates were reported from a wide range of countries spanning all continents. Five studies reported data from North America, 11 from South America, 21 from Europe, 33 from Asia, 5 from Africa, 2 from Australia, and 1 from both North America and Europe (we did not pool this study for results based on continent of origin). Demographic data were not consistently reported across studies, and we were not able to perform subgroup analyses based on age or gender.…”

Section: Resultsmentioning

confidence: 99%

“…Different countries have reported HPgV‐1 prevalences ranging from low ones from developed regions like North America (1–3·8%) , Europe (1·6–3·8%) and Australia (4%) to higher ones from countries like Brazil (21·7%), China (18·2%) and South Africa (18·9%) . However, the global prevalence of HPgV‐1 amongst blood donors remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Global prevalence of human pegivirus‐1 in healthy volunteer blood donors: a systematic review and meta‐analysis

2019

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Background and objectives The local prevalence of HPgV-1 has been reported from different countries worldwide, but the global prevalence of HPgV-1 remains unknown. The aim of this systematic review and meta-analysis was to gather data from the literature to estimate the prevalence of HPgV-1 in healthy volunteer blood donors in the world. Materials and methodsWe searched PubMed, EMBASE, Scopus and Google Scholar databases for records up to January 2019 and included studies reporting HPgV-1 virus prevalence amongst healthy volunteer blood donors based on the detection of HPgV-1 RNA.Results In all, we included 79 studies for the systematic review and 63 for the meta-analysis. Based on the random effect meta-analysis of 35 468 volunteer blood donors, we found the global prevalence of HPgV-1 to be 3Á1% (95% CI, 2Á4-4Á1). The pooled prevalences of HPgV-1 were 1Á7% (95% CI, 1Á1-2Á6) in North America, 9Á1% (95% CI, 6Á4-12Á7) in South America, 2Á3% (95% CI, 2%, 2Á8) in Europe and 2Á4% (95% CI, 1Á4-4) in Asia. Subgroup analyses based on age, gender or risk factors were not possible.Conclusion Approximately 3 in 100 blood donations worldwide are positive for HPgV-1 increasing the risk of infection from transfusion of their components to subsequent recipients. Further research on virus pathogenicity is required before recommending routine screening of HPgV-1 for healthy volunteer blood donors.

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Infection with GB virus C/hepatitis G virus among blood donors and hemophiliacs in Martinique, a Caribbean Island

Cited by 8 publications

References 26 publications

Antibodies to the E2 Protein of GB Virus C/Hepatitis G Virus: Prevalence and Risk Factors in Different Populations in Italy

Antibodies to the E2 Protein of GB Virus C/Hepatitis G Virus: Prevalence and Risk Factors in Different Populations in Italy

Frequency and genotypic distribution of GB virus C (GBV-C) among Colombian population with Hepatitis B (HBV) or Hepatitis C (HCV) infection

Global prevalence of human pegivirus‐1 in healthy volunteer blood donors: a systematic review and meta‐analysis

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