Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer

Giraldi, Luca; Collatuzzo, Giulia; Hashim, Dana; Franceschi, Silvia; Herrero, Rolando; Chen, Chu; Smith, Elaine; Kelsey, Karl T.; McClean, Michael D.; Gillison, Maura L.; Boccia, Stefania; Hashibe, Mia; Lee, Yuan Chin Amy; Boffetta, Paolo

doi:10.1016/j.canep.2021.102020

Cited by 27 publications

(20 citation statements)

References 35 publications

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“…Head and neck malignancies encompass a diverse group of aggressive tumors arising at the epithelium of the upper aerodigestive tract mucosal linings, squamous cell carcinoma being the most frequent histopathological type (90%). Head and neck squamous cell carcinoma (HNSCC) has been associated with external risk factors such as smoking habits, alcohol consumption, and infection with herpes papillomavirus (HPV) or Epstein-Barr virus (EBV), all of which are reflected in the genomic and transcriptomic profiles of their respective factor-based subtypes [ 1 , 2 , 3 , 4 , 5 ]. Furthermore, genetic predisposition has been identified as a risk factor for developing head and neck cancers in a growing number of patients [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Tracking the Molecular Fingerprint of Head and Neck Cancer for Recurrence Detection in Liquid Biopsies

Diez-Fraile

Ceulaer

Derpoorter

et al. 2022

IJMS

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The 5-year relative survival for patients with head and neck cancer, the seventh most common form of cancer worldwide, was reported as 67% in developed countries in the second decade of the new millennium. Although surgery, radiotherapy, chemotherapy, or combined treatment often elicits an initial satisfactory response, relapses are frequently observed within two years. Current surveillance methods, including clinical exams and imaging evaluations, have not unambiguously demonstrated a survival benefit, most probably due to a lack of sensitivity in detecting very early recurrence. Recently, liquid biopsy monitoring of the molecular fingerprint of head and neck squamous cell carcinoma has been proposed and investigated as a strategy for longitudinal patient care. These innovative methods offer rapid, safe, and highly informative genetic analysis that can identify small tumors not yet visible by advanced imaging techniques, thus potentially shortening the time to treatment and improving survival outcomes. In this review, we provide insights into the available evidence that the molecular tumor fingerprint can be used in the surveillance of head and neck squamous cell carcinoma. Challenges to overcome, prior to clinical implementation, are also discussed.

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Section: Introductionmentioning

confidence: 99%

Tracking the Molecular Fingerprint of Head and Neck Cancer for Recurrence Detection in Liquid Biopsies

Diez-Fraile

Ceulaer

Derpoorter

et al. 2022

IJMS

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“…Among high-risk genotypes of HPV, HPV16 infection is importantly involved in the development of oral cancers. 5 HPV16 DNA was detected in 82% of oral epithelial dysplasia cases that progressed to oral squamous cell carcinoma, suggesting that HPV16 plays an important role in the malignant transformation of oral epithelial dysplasia. 6 In contrast, the HPV18-positive rate is very low in oral cancers, suggesting that HPV16 rather than HPV18 is commonly associated with oral cancers.…”

Section: Introductionmentioning

confidence: 99%

“…6 In contrast, the HPV18-positive rate is very low in oral cancers, suggesting that HPV16 rather than HPV18 is commonly associated with oral cancers. 5 However, oral HPV16/18 infection has not been fully investigated in Japanese people without oral cancer or oral premalignant lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, a sex‐specific susceptibility to HPV infection may play a vital role in the prevalence of HPV DNA in the oral cavity. Among high‐risk genotypes of HPV, HPV16 infection is importantly involved in the development of oral cancers 5 . HPV16 DNA was detected in 82% of oral epithelial dysplasia cases that progressed to oral squamous cell carcinoma, suggesting that HPV16 plays an important role in the malignant transformation of oral epithelial dysplasia 6 .…”

Section: Introductionmentioning

confidence: 99%

“…HPV16 DNA was detected in 82% of oral epithelial dysplasia cases that progressed to oral squamous cell carcinoma, suggesting that HPV16 plays an important role in the malignant transformation of oral epithelial dysplasia 6 . In contrast, the HPV18‐positive rate is very low in oral cancers, suggesting that HPV16 rather than HPV18 is commonly associated with oral cancers 5 . However, oral HPV16/18 infection has not been fully investigated in Japanese people without oral cancer or oral premalignant lesions.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for oral HPV16/18 and candida in Japanese people without oral cancer or premalignant lesions

Shigeishi

Ohta

Sugiyama

2022

Oral Science International

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Aim Current studies indicate that oral human papillomavirus (HPV) and candida infection may increase the risk of developing oral cancer. The objective of this study was to investigate the risk factors for HPV16/18 and candida infection in the oral cavity in Japanese people without oral cancer or premalignant lesions. Methods We targeted 181 Japanese patients (mean age 59.8 years, range 20–89 years) who visited Hiroshima University Hospital. None of the patients had oral cancer or oral potentially malignant disorder. Oral rinse samples were collected after mouth rinsing. Real‐time polymerase chain reaction (PCR) was performed using type‐specific primers to detect HPV16/18 DNA and Candida albicans/Candida glabrata DNA. Results Of the 181 participants, 20 participants (11.0%) were HPV16 DNA positive and three participants (1.7%) were HPV18 DNA positive. Smoker had significant higher positive rates of HPV16 DNA than nonsmoker (P = 0.03). Additionally, binomial logistic regression analysis revealed that smoking was significantly associated with HPV16 DNA (odds ratio 4.11, P = 0.01). Six participants (3.3%) showed co‐infection with HPV16 and C. albicans. No significant association was found between HPV16/18 and C. albicans/C. glabrata. Logistic regression analysis revealed that denture use was significantly associated with C. glabrata (odds ratio 5.09, P = 0.003). Conclusions Tobacco smoke is an important risk factor for oral HPV16 infection. Co‐infection with oral HPV16 and C. albicans can be found in people without oral cancer. Our results highlight the importance of not smoking and regularly cleaning dentures to prevent co‐infection with HPV and candida.

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Human papillomavirus infection and non-oropharyngeal head and neck cancers: an umbrella review of meta-analysis

Petrelli

Cin²,

Ghidini

et al. 2023

Eur Arch Otorhinolaryngol

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Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer

Cited by 27 publications

References 35 publications

Tracking the Molecular Fingerprint of Head and Neck Cancer for Recurrence Detection in Liquid Biopsies

Tracking the Molecular Fingerprint of Head and Neck Cancer for Recurrence Detection in Liquid Biopsies

Prevalence and risk factors for oral HPV16/18 and candida in Japanese people without oral cancer or premalignant lesions

Human papillomavirus infection and non-oropharyngeal head and neck cancers: an umbrella review of meta-analysis

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