Infection with Lagochilascaris minor

Draper, J. W.

doi:10.1136/bmj.1.5335.931

Cited by 15 publications

(5 citation statements)

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“…Human lagochilascariasis has been recorded in Trinidad and Tobago [ 1 , 2 , 18 , 23 ], Surinam [ 14 , 20 , 24 , 25 ], Mexico [ 9 , 26 ], Costa Rica [ 27 ], Venezuela [ 6 , 15 , 28 ], Colombia [ 11 , 12 ], Bolivia [ 29 ], Ecuador [ 30 ], Paraguay [ 7 ], Brazil [ 3 – 5 , 10 , 13 , 16 , 21 , 31 – 35 ] and Peru [ 36 ] ( Fig 1 ). As for its geographic distribution by country, the highest concentration is found in Brazil, representing 78.1% (100/128) of the total number of cases reported in the literature [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Human lagochilascariasis—A rare helminthic disease

et al. 2017

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Lagochilascariasis is a parasitic disease caused by a helminth of the order Ascaroidea, genus Lagochilascaris that comprises 6 species, among which only Lagochilascaris minor Leiper, 1909, is implicated in the human form of the disease. It is remarkable that the majority of cases of human lagochilascariasis in the Americas have been reported in Brazil. The natural definitive hosts of this parasite seem to be wild felines and canines. Lagochilascariasis is mostly a chronic human disease that can persist for several years, in which the parasite burrows into the subcutaneous tissues of the neck, paranasal sinuses, and mastoid. L. minor exhibits remarkable ability to migrate through the tissues of its hosts, destroying even bone tissue. Fatal cases have been described in which the parasite was found in the lungs or central nervous system. Treatment is often palliative, with recurrence of lesions. This paper summarizes the main features of the disease and its etiologic agent, including prevalence, life cycle, clinical course, and treatment.

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Section: Methodsmentioning

confidence: 99%

Human lagochilascariasis—A rare helminthic disease

et al. 2017

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“…Lagochilascariosis has been found in Brazil, Colombia, Venezuela, Mexico, Costa Rica, Trinidad and Tobago, Suriname, Bolivia and Paraguay 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 . Human infections are caused by eating raw or undercooked meat of wild rodents which are naturally infected by the parasite 15 , 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

Campos

Barbosa

Oliveira

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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Lagochilascariosis, a disease caused by Lagochilascaris minor, affects the neck, sinuses, tonsils, lungs, the sacral region, dental alveoli, eyeballs and the central nervous system of humans. A cycle of autoinfection may occur in human host tissues characterized by the presence of eggs, larvae and adult worms. This peculiarity of the cycle hinders therapy, since there are no drugs that exhibit ovicidal, larvicidal and vermicidal activity. Given these facts, we studied the action of levamisole hydrochloride on third-stage larvae in the migration phase (G1) and on encysted larvae (G3) of L. minor. To this end, 87 inbred mice of the C57BL/6 strain were divided into test groups comprising 67 animals (G1-37; G3-30) and a control group (G2-10; G4-10) with 20 animals. Each animal was inoculated orally with 2,000 infective eggs of the parasite. The animals of the test groups were treated individually with a single oral dose of levamisole hydrochloride at a concentration of 0.075 mg. The drug was administered either 30 minutes prior to the parasite inoculation (G1 animals) or 120 days after the inoculation (G3 animals). The mice in the control groups were not treated with the drug. After the time required for the migration and the encysting of L. minor larvae, all the animals were euthanized and their tissues examined. The data were analyzed using the Student's unpaired t-test and the Levene test. The groups showed no statistically significant difference. Levamisole hydrochloride was ineffective on third-stage larvae of L. minor. These findings explain the massive expulsion of live adult worms, as well as the use of long treatment schemes, owing to the persistence of larvae and eggs in human parasitic lesions.

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“…O primeiro registro de lagochilascariose em Tobago foi descrito por Draper (1963). Tratava-se de uma paciente com 39 anos de idade que desde 1957 apresentava tumoração no pescoço.…”

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“…Tratamento com Banocide apresentou notável efeito, pois vários vermes emergiam após cada dose, além de provocar melhora do estado geral da paciente. Draper (1963) considerou o homem como um hospedeiro anormal admitindo que o referido parasito teria como habitat o intestino de animais selvagens. Neste mesmo ano, Draper diagnosticou outro caso de lagochilascariose no pescoço, seio maxilar e fossas paranasais de uma paciente de Tobago que relatava o costume de se alimentar de carne crua, o que poderia ter lhe servido como fonte de infecção.…”

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Lagochilascaris núnor Leiper, 1909: NOVE DÉCADAS DE REVISÃO BIBLIOGRÁFICA

Paçô¹,

Campos²

2007

Rev Patol Trop

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A lagochilascariose é uma infecção causada por vermes do género Lagochilascaris. A doença humana é restrita ao continente americano e tem sido associada a Lagochilascaris minor. É considerada uma helmintíase emergente e o Brasil lidera a casuística mundial com aproximadamente 90% dos casos descritos na literatura mundial. Esta revisão tem como objetivo divulgar informações sobre a lagochilascariose desde a época em que foi descrita até os dias atuais.UNITERMOS: Lagochilascaris minor. Lagochilascariose. Helmintíase emergente. INTRODUÇÃOEmbora Lagochilascaris minor tenha sido descrito, desde 1909, em material procedente de lesão humana, até hoje não se conhecem os hospedeiros naturais deste helminto. Esta espécie tem sido encontrada determinando lesões tumorais geralmente fistulizada no homem e, eventualmente, em cães e gatos domésticos. As lesões humanas localizam-se na região cervical e tecidos relacionados, como mastóide, maxila, tonsila, globo ocular, pescoço, seios nasais, ouvido, sistema nervoso central, pulmão, rinofaringe, alvéolo dentário, além da região sacra. A infecção humana pode ter evolução crónica, de 5 a 20 anos de duração, ou levar o indivíduo ao óbito três meses após o início dos sintomas.A distribuição geográfica da lagochilascariose humana é restrita a países da região neotropical como México,

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Infection with Lagochilascaris minor

Cited by 15 publications

References 1 publication

Human lagochilascariasis—A rare helminthic disease

Human lagochilascariasis—A rare helminthic disease

EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

Lagochilascaris núnor Leiper, 1909: NOVE DÉCADAS DE REVISÃO BIBLIOGRÁFICA

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