Infection With Organisms of Vincent's Angina Following Human Bite

Fuller, CJ; Cottrell, John C.

doi:10.1001/jama.1929.92700500004009b

Cited by 13 publications

(2 citation statements)

References 3 publications

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“…The earliest reports of the bacteriology of infected human bites noted spirochetes and fusiform bacteria, terms suggesting the presence of typical oral and anaerobic flora [14][15][16][17][18][19][20]. Later investigations identified a-streptococci and S. aureus as the most frequent pathogens [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

Talan¹,

Abrahamian²,

Moran³

et al. 2003

Clinical Infectious Diseases

169

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Previous studies of infected human bites have been limited by small numbers of patients and suboptimal microbiologic methodology. We conducted a multicenter prospective study of 50 patients with infected human bites. Seventy percent of the patients and assailants were young adult men. Fifty-six percent of injuries were clenched-fist injuries and 44% were occlusional bites. Most injuries were to the hands. Fifty-four percent of patients were hospitalized. The median number of isolates per wound culture was 4 (3 aerobes and 1 anaerobe); aerobes and anaerobes were isolated from 54% of wounds, aerobes alone were isolated from 44%, and anaerobes alone were isolated from 2%. Isolates included Streptococcus anginosus (52%), Staphylococcus aureus (30%), Eikenella corrodens (30%), Fusobacterium nucleatum (32%), and Prevotella melaninogenica (22%). Candida species were found in 8%. Fusobacterium, Peptostreptococcus, and Candida species were isolated more frequently from occlusional bites than from clenched-fist injuries. Many strains of Prevotella and S. aureus were beta-lactamase producers. Amoxicillin-clavulanic acid and moxifloxacin demonstrated excellent in vitro activity against common isolates.

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Section: Discussionmentioning

confidence: 99%

Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

Talan¹,

Abrahamian²,

Moran³

et al. 2003

Clinical Infectious Diseases

169

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“…The organisms most commonly involved in human bite infections are combinations of skin and the oral flora. Early studies from the 1920s and 1930s isolated the organisms of Vincent’s angina, 3,13 these being the spirochaete Borrelia and the anaerobic bacterium Fusobacterium which acted synergistically to produce a gangrenous infection. Maier found it to be the most frequent cause of infection in his series 9 .…”

Section: Literature Reviewmentioning

confidence: 99%

Human bites of the hand: The Tasmanian experience

Tonta

Kimble

2001

ANZ Journal of Surgery

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The treatment of human bites must be early, correct and comprehensive. The appropriate treatment is surgical exploration with debridement and lavage, appropriate antibiotic administration, hand elevation and initial immobilization. Poor compliance of patients in the present study was demonstrated by a high incidence of late presentation, self-discharge from hospital and loss to follow up, making assessment of outcomes difficult. Despite this there is an absence of serious hand infections reported in the literature and this may be due to the administration of antibiotics prior to referral.

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The Pathogenicity of the Fusiform Bacillus and Spirillum of Plaut-Vincent

Lichtenberg¹,

Werner²,

Lueck³

1933

JAMA

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It has been quite generally accepted that the Pl aut\x=req-\ Vincent organisms have a pathogenic relationship to a variety of clinical entities. Unexceptionable proof of such relationship is wanting. The purpose of this report is to record clinical and experimental observations bearing on this subject. This study was undertaken at the suggestion of Dr. Joseph Brennemann.In the course of a study of a large series of diphtheria patients Plaut,1 in 1894, came on five cases of non\x=req-\ diphtheritic membranous angina, at first taken for diphtheria, in which fusiform bacilli and spirochetes were found. Plaut called these "Miller's organisms," since these had been described in 1883 by an American dentist, Willoughby D. Miller, who stated that pathogenic properties had already been ascribed to these organisms by Verneuil and Clado, who had found them in abscesses of the sublingual salivary gland, in submaxillary adenitis and in an abscess of a finger due to a human bite. Although the organisms were found beneath the gum margins in almost every mouth, and their numbers were greatly increased in gingivitis, Plaut believed them to be the causative agent in the anginas because the organisms were present in such great num¬ bers, in two instances in pure culture.In 1896, and more fully in 1899, Vincent2 described two diseases of the mucous membrane of the mouth and pharynx which he ascribed to the fusospirochetal organisms. The first was a mild stomatitis with super¬ ficial ulcérations, with a subfebrile course lasting two or three days. The ulcérations were covered with membranes, which came off easily but reformed to a less degree and gradually disappeared. In the second form a deep ulcer, which bled easily, lay beneath the membrane ; the fever was high, and a marked adenitis and a reddened edematous pharynx were present. The disease ran a protracted course, in one patient for two months. In the first form he found only the fusiform bacillus, while in the severer, ulceromembranous form From the Otho S. A. Sprague Memorial Institute Laboratory and the Children's Memorial Hospital. 1. Plaut, H. C.: Studien zur bacteriellen Diagnose der Diphtherie und den Anginen, Deutsche med. Wchnschr. 20: 920, 1894. 2. Vincent, M. H.: Recherches bact\l=e'\riologiquessur l'angine \l =a`\bacillus fusiformis, Ann. l'Inst. Pasteur 13: 609, 1899.the bacillus was associated with a spirillum in fifteen out of eighteen cases. Vincent was unable to reproduce the disease in the mouth or vagina of animals, and subcutaneous injections of the mixed organisms resulted in abscesses in which only pus organisms were found*. He was unable to cultivate the organisms and satisfac¬ torily attest their pathogenicity.Weaver and Tunnicliff3 in 1905 described the presence of the fusiform bacillus and spirillum in ulcerative stomatitis and succeeded in cultivating the bacillus anaerobically. These investigators were unable to produce any disease in rabbits with pure cultures. When mixed cultures were injected into the ears of rabbits, gangrene of the skin and deat...

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Infection With Organisms of Vincent's Angina Following Human Bite

Abstract: prominently seen were the degenerated nuclear granules and the presence of the varying sized lipoid globules.A diagnosis of mucoid cyst of the appendix was made. A letter from the patient one year and five months later stated that she was well and enjoying good health. 70S Walnut Street.

Cited by 13 publications

References 3 publications

Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

Clinical Presentation and Bacteriologic Analysis of Infected Human Bites in Patients Presenting to Emergency Departments

Human bites of the hand: The Tasmanian experience

The Pathogenicity of the Fusiform Bacillus and Spirillum of Plaut-Vincent

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