Infections after Endoscopic Polypectomy Using Nasal Steroids

Abstract

The use of nasal steroids does not seem to increase the prevalence of infections after endoscopic polypectomy.

Role of corticosteroids in Functional Endoscopic Sinus Surgery - a systematic review and meta-analysis

“…Eighteen studies satisfied the selection criteria and were included in this review (12)(13)(14)23,24,26,(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63) . In total 1309 patients were included in this review.…”

“…RCTs for anaesthetic outcomes (n=1) (58) 3. RCTs for post-operative outcome and Recurrence Rate (n =14) (12,23,24,26,(52)(53)(54)(55)(56)(57)(59)(60)(61)(62)(63) * Wright et al (55) reported on operative and post-operative outcomes hence mentioned twice. design in which one side of the nasal cavity was compared with the other side (n=182) (24,59,60,62) .…”

“…These studies were included in the meta-analysis and the two groups treated as independent, and then sensitivity analysis was performed excluding these studies to determine the robustness of the results. (13,14,55) ; anaesthetic outcomes were reported by one study (58) ; post-operative outcomes were reported by ten studies (12,23,24,26,54,55,57,59,61,62) , and risk of recurrence was reported by six studies (52,53,56,59,60,63) . One RCT reported both on operative and post-operative outcomes, therefore it was included in both categories (55) .…”

“…Risk of sinusitis as an adverse event associated with the use of corticosteroids was reported by four studies (12,52,54,60) . Cote et al (24) used triamcinolone impregnated packs, Bross-Sariano et al (52) used fluticasone or beclomethasone spray, Rowe-Jones et al (54) used fluticasone sprays, and Marple et al (60) used mometasone furoate releasing stents. Pooling of the results showed no significant difference between use of corticosteroids and no corticosteroids (RR 0.64; 95% CI 0.32, 1.30; P = 0.22; Figure 5B).…”

Pharmacologic management of chronic rhinosinusitis, alone or with nasal polyposis

“…Several small trials (< 25 patients) demonstrated a trend toward reduced polyp regrowth after sinus surgery in patients treated with intranasal steroids compared with placebo controls [46,47]. Bross-Soriano et al [48] reported a prospective study of 162 patients divided into three groups postpolypectomy, one receiving daily saline lavages, and the other two saline lavages followed by either fluticasone or beclomethasone. At 12 months, early polyp recurrence was evident in 44% of those on saline alone, 15% of those also receiving fluticasone, or 26% with beclomethasone.…”