Infections and association with different intensity of chemotherapy in children with acute myeloid leukemia

Abstract

Objective Arthritis is the most common health condition in midlife and late life, and heart disease is the leading cause of death. This article compares disability impacts of these 2 preeminent health problems. Methods Using data from the National Health Interview Survey Disability Supplement, we studied specific limitations and disabilities, accommodations used (buffers), and accommodations needed (barriers) for US population groups of adults with arthritis disability, heart disease disability, both arthritis and heart disease disability, and disability due to other conditions. Weights and complex SE adjusted for sample design. We hypothesized that arthritis disability is more extensive and troublesome than heart disease disability. Results People with arthritis disability had more numerous, longer, and more bothersome disabilities than people with heart disease disability. People with arthritis disability used more equipment and rehabilitation, whereas people with heart disease disability emphasized personal assistance, medications, and medical services. People with arthritis disability experienced more barriers and needs in activities and services. People with disabilities from both arthritis and heart disease were especially disadvantaged, with high levels of limitations and accommodations. People with disability from other conditions had the highest social participation, fewest disabilities, and most tailored accommodations of all groups. Conclusion Arthritis had higher and more extensive disability impact than heart disease. Both groups had more difficulty, buffers, and barriers in their lives than people disabled by other conditions. Therefore, arthritis and heart disease are premier conditions for disability attention and alleviation in the US population.

Inducible epithelial resistance protects mice against leukemia-associated pneumonia

“…Recent series report microbiologically documented respiratory infections in 14% to 60% of AML patients, varying with treatment regimen. 14,[40][41][42] The most commonly isolated pathogens in this population are the Gram-negative bacterium P. aeruginosa, the Gram-positive bacterium S. pneumoniae and the endemic fungus A. fumigatus. [40][41][42][43][44][45] Here, we demonstrate robust protection against all 3 frequently documented causes of pneumonia.…”

Caracterización de los episodios de neutropenia febril en niños con leucemia mieloide aguda y leucemia linfoblástica aguda

“…En este estudio prospectivo y multicéntrico, se pudo objetivar la mayor frecuencia y gravedad de las infecciones ocurridas en pacientes con diagnóstico de LMA, lo cual es concordante con la revisión de la literatura científica [5][6][7] , dado principalmente por la mayor intensidad de los esquemas de QT recibidos, lo que provoca períodos de neutropenia más prolongados y profundos…”

“…Inmunocomprometidos amplio espectro, aparición de resistencia antimicrobiana e incremento de sobre-infecciones asociadas [6][7][8] . El objetivo de este estudio fue describir los episodios de neutropenia febril (NF) en pacientes bajo 18 años de edad, con LMA, determinando la frecuencia de infecciones según agente, foco infeccioso y evolución clínica, comparándolos con los observados en niños con LLA.…”

Çocukluk Çağında Akut Myeloid Lösemi

“…AML tedavisinde kemoterapi esnasında ve sonrasında hastaların destek tedavileri önem arz etmektedir. Yapılan çalışmalar akut miyeloid lösemi hastalarında şiddetli bakteriel sepsis riskinin %50-60 ve fungal enfeksiyon riskinin %7-13 olduğunu göstermiştir 23,24 . Trombosit sayımı 10.000/dL ve altında olanlarda semptomatik anemi ya da ek risk faktörü olmasa bile, destekte bulunulması önerilmektedir 1 .…”