Infections and Ischemic Stroke Outcome

Grabska, Katarzyna; Gromadzka, Grażyna; Członkowska, Anna

doi:10.1155/2011/691348

Cited by 27 publications

(27 citation statements)

References 33 publications

(35 reference statements)

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“…Two recent studies found no independent influence between PI and 3-month outcome. 9,10 However, the latter study showed unfavorable 30-day outcome in those with PI. 10 Another stroke-related infectious phenomena are poststroke infections (PSIs) that occur during the acute phase (0-7 days after the stroke).…”

mentioning

confidence: 80%

“…9,10 However, the latter study showed unfavorable 30-day outcome in those with PI. 10 Another stroke-related infectious phenomena are poststroke infections (PSIs) that occur during the acute phase (0-7 days after the stroke). PSIs have frequent medical complications: urinary tract infections occur in 10% to 29% and chest infections in 11.2% to 18% of the cases.…”

mentioning

confidence: 80%

“…Median duration of hospital stay was longer in patients with PSI than in those without (20 days versus 10 [7][8][9][10][11][12][13][14] days; P<0.001).…”

Section: Poststroke Infectionsmentioning

confidence: 94%

“…Median duration of hospital stay was similar in patients with and without PIs (12 [7][8][9][10][11][12][13][14][15][16][17][18][19] days versus 10 [7][8][9][10][11][12][13][14][15][16][17] …”

Section: Preceding Infectionsmentioning

confidence: 94%

“…26 Stroke severity on admission was assessed by the National Institutes of Health Stroke Scale (NIHSS) and categorized as mild (0-6), moderate, [7][8][9][10][11][12][13][14] or severe (≥15). All patients underwent routine brain imaging, computed tomography, or MRI on admission.…”

Section: Stroke Characteristicsmentioning

confidence: 99%

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Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Heikinheimo

Broman

Haapaniemi

et al. 2013

Stroke

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This retrospective study is based on the Helsinki Young Stroke Registry data. The registry includes all consecutive 15-to 49-year-old Background and Purpose-Poststroke infections (PSIs) worsen the outcome in acute ischemic stroke, but the effect of preceding infection (PI) is controversial. Data on young patients are scarce. We characterized PI and PSI in young adults with first-ever stroke and studied whether they are associated with 3-month and long-term outcomes, recurrent vascular events, and death. Methods-From our database of 1008 consecutive patients aged 15 to 49 years, we included in the present study those who had brain imaging done within the first 2 days from stroke onset. Outcomes were unfavorable at 3 months and during long-term follow-up, vascular events, and all-cause death. Logistic regression and Cox proportional models were used to determine associations between infections and clinical outcomes. Results-A total of 681 patients (62.3% men) fulfilled the inclusion criteria. Of these, 70 (10.3%) had PI, most commonly upper respiratory tract infection, and 103 (15.1%) had PSI, most commonly pneumonia. After adjusting for sex, age, and risk factors, both PI (odds ratio, 2.86; 95% confidence interval, 1.48-5.54) and PSI (odds ratio, 2.26; 95% confidence interval, 1.08-4.76) were independently associated with unfavorable 3-month outcome. PSI was also associated with long-term (follow-up, 7.8±4.0 years) higher risk of all-cause death. Conclusions-In young patients with ischemic stroke, both PI and PSIs are associated with unfavorable short-term outcome.PSIs are also associated with higher long-term mortality. (Stroke. 2013;44:3331-3337.)

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mentioning

confidence: 80%

mentioning

confidence: 80%

“…Median duration of hospital stay was longer in patients with PSI than in those without (20 days versus 10 [7][8][9][10][11][12][13][14] days; P<0.001).…”

Section: Poststroke Infectionsmentioning

confidence: 94%

Section: Preceding Infectionsmentioning

confidence: 94%

Section: Stroke Characteristicsmentioning

confidence: 99%

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Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Heikinheimo

Broman

Haapaniemi

et al. 2013

Stroke

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Infectious Burden and Risk of Stroke

Luna¹,

Elkind²

2013

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

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The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study

Consoli

Vidale²,

Aguglia

et al. 2015

J Neurol

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Although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56%) patients were enrolled in this prospective case-control study by 11 Italian Stroke Units. Demographic data, vascular risk factors, previous infections and post-stroke infections (PSIs) were recorded. Blood samples were collected and the enzyme-linked immunoassay was chosen to measure Chlamydia pneumoniae IgG and IgA plasma antibodies (antibody titers were classified with specific cut-off levels: IgA > 1:16 and IgG > 1:64). Early poor outcome was defined as mRS score >2 at discharge, while poor outcome at 6-month follow-up. Univariate and multivariate analyses were performed. Median NIHSS was 7, IgA and IgG antichlamydia pneumoniae seropositivities were observed in 308 (37.1%) and 207 (23.6%) patients, respectively. Multivariate analyses showed significant correlations between PSIs and NIHSS (RR: 1.06; 95% CI 1.02-1.09; p < 0.001) and PSIs and IgA antichlamydia pneumoniae seropositivity (RR: 3.84; 95% CI 2.53-5.84; p < 0.001). Significant disability was associated with baseline NIHSS (RR: 1.32; 95% CI 1.16-1.50; p < 0.001), IgA (RR: 2.67; 95% CI 1.06-6.70; p = 0.035) and IgG antichlamydia (RR: 5.75; 95% CI 1.83-18.03; p = 0.003) seropositivity and atrial fibrillation (RR: 2.58; 95% CI 1.81-3.67; p < 0.001). While previous infections were not associated with functional outcome, antichlamydia antibodies play a negative role in ischemic stroke patients. Preventive strategies may reduce the stroke burden and improve the clinical outcome.

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Infections and Ischemic Stroke Outcome

Cited by 27 publications

References 33 publications

Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Infectious Burden and Risk of Stroke

The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study

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