Infections and vaccinations preceding childhood Guillain-Barré syndrome: a prospective study

Abstract

We conclude that, in contrast to adults, Campylobacter spp. does not seem to play a major role in childhood GBS in German-speaking countries. The aetiology of antecedent diseases is distributed over a wide spectrum of paediatric infectious diseases. Most of the children who had been vaccinated showed concomitant infectious diseases, thus obscuring the causative role for GBS.

Prospective study on anti-ganglioside antibodies in childhood Guillain-Barre syndrome

“…All but five patients were treated with IVIG (2 g/kg twice weekly in 2 or 5 days). The first improvement by 1 point on the GBS score occurred after a median time of 15 days (interquartile range (IQR) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Children who had been unable to walk regained the ability to walk unaided at a median time of 25 days after onset of GBS (IQR 13-50 days), and symptoms disappeared during the follow-up period in 46 patients at a median time of 121 days after onset (IQR 77-188).…”

“…12 13 Moreover, in the children with GBS, further serological tests for 24 infective agents were carried out prospectively. 14 Statistical evaluation was carried out using the program package SPSS V.11.0.1. Correlations of the serological findings with clinical data were investigated with contingency table analysis (Fisher's exact test for 262 tables and x 2 test for n6k tables) and non-parametric Mann-Whitney U test, as appropriate.…”

Delayed Recognition of Guillain-Barré Syndrome in a Child: A Misleading Respiratory Distress

“…The viruses involved are, mainly, the herpes family viruses and human immunodeficiency virus. Among the bacterial agents, Mycoplasma pneumoniae and Campylobacter jejuni are often mentioned (6). Strong evidence supports an important role of antibodies to neural gangliosides in the pathogenesis of GBS.…”

Периферійна Нейропатія При Хламідійному Реактивному Артриті

“…У больных с другими артритами (ревматоидный, псориатиче-ский, анкилозирующий спондилит) уже достаточно хорошо известно развитие ПНП [6,9,12], тогда как при РХА такое поражение нервной системы пока описывается в виде единичных наблюдений, хотя нейропатия считается прогнознегативным фактором течения этого заболевания [14]. Воспалительно-де-генеративные изменения нервов в виде ПНП спо-собны вызывать Chlamydia psittaci [10] и Chlamydia pneumoniae [2,4,11].…”