Infections Associated With Giving Medical
Care in Hospitals of Russia: Experience of Meta Analysis Of
Morbidity

Rotavirus infection is ubiquitously distributed and represents a global public health problem. Some studies showed that vaccination with pentavalent oral live vaccine was effective in prevention of severe forms of rotavirus gastroenteritis among children up to 3 years of age. Previous randomized placebo-controlled studies assessing this issue were repeatedly conducted. However, due to the features of the epidemiology of pediatric rotavirus infection inRussia, a meta-analysis was conducted in the risk group – children under the age of 3 years by administering a full vaccination course for a single vaccine registered in theRussian Federation. A search was performed by two independent reviewers covering 1994 to February 2019, without restrictions on language, in five databases on medical and biological publications: Russian Science Citation Index, PubMed, Web of Science, MEDLINE, Scopus, and in contents of thematic journals and bibliographic lists. The meta-analysis included multicenter randomized controlled trials comparing the efficacy of placebo and completed full vaccination course with pentavalent live oral rotavirus vaccine in children under 3 years of age. The primary endpoint of the study was the incidence of severe gastroenteritis among children according to the Vesikari evaluation system. Data processing and generation of forest-plots to evaluate summarized results were carried out by the RevMan 5.3 free software distributed on the Cochrane Community website. The implementation of the “Trim and fill” method was performed by using Stata 14.2 software. The meta-analysis consisted of 7 original publications performed as multicenter randomized, placebo-controlled double-blind studies. In the experimental and control group there were enrolled 19,384 and 19,425 subjects, respectively. Three-dose vaccination protocol markedly reduced a risk of infection with severe rotavirus gastroenteritis in the experimental group compared to control group, the odds ratio was 0.34 [95% CI 0.19-0.60]. Cluster analysis also confirmed the protective effect of the full vaccination course. Group assessment of the vaccination effectiveness against rotavirus infection in countries of Africa and Southeast Asia showed significant protection, the odds ratio was 0.60 [95%, CI 0.52-0.70]. While evaluating the effectiveness of vaccination against rotavirus infection inFinland, the odds ratio was set at the level of statistical significance and reached 0.07 [95%, CI 0.04-0.11]. Thus, a full vaccination course with pentavalent live oral vaccine against rotavirus infection lowers a risk of developing severe rotavirus gastroenteritis in young children.

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Meta-analysis of the effectiveness of pentavalent live oral vaccine for the prevention of severe forms of rotavirus gastroenteritis in children

Косова

Bashkirova

Mashin

et al. 2020

Russian Journal of Infection and Immunity

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Epidemiological surveillance of healthcare-associated infections and the problem of underestimating cases: Results of sociological study in medical organizations of Khanty-Mansiysk Autonomous Okrug — Ugra

Chalapa¹,

Косова²,

Zhuykov³

et al. 2020

Profil. med.

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Prospects for Phagоtherapy of Bacterial Infections Associated with the Provision of Medical Care

Daudova

Abdrakhmanova

Ясенявская

et al. 2023

A&Ch

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Healthcare-associated infections (HAIs) are a global medical and socioeconomic problem. Nosocomial infections occupy one of the leading places among the causes of death in the Russian Federation. About 60–70% of all nosocomial infections are associated with the use of medical implants of various proﬁles. Pseudomonas aeruginosa, various types of streptococci, staphylococci, Escherichia coli, enterococci (Enterococcus faecalis), Klebsiella pneumoniae, Proteus mirabilis, and representatives of the genus Acinetobacter are highly likely to be found in bioﬁlms of medical supplies. A distinctive feature of microbes that cause HAIs is poly- or even pan-resistance of microbes to recommended antimicrobials. The search for methods and means to overcome is a priority task of modern medicine. Phage therapy seems to be one of the logical and promising ways to combat bacteria that are resistant to conventional therapy. The article outlines the advantages and disadvantages of phage therapy, provides an overview of the successful use of mono- and combined preparations of bacteriophages in the experiment and clinic, as well as modern directions for the use of bacteriophages not only for therapeutic, but also for prophylactic purposes, based on the latest achievements of genetic engineering and biotechnology.

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Infections Associated With Giving Medical Care in Hospitals of Russia: Experience of Meta Analysis Of Morbidity

Cited by 3 publications

References 6 publications

Meta-analysis of the effectiveness of pentavalent live oral vaccine for the prevention of severe forms of rotavirus gastroenteritis in children

Meta-analysis of the effectiveness of pentavalent live oral vaccine for the prevention of severe forms of rotavirus gastroenteritis in children

Epidemiological surveillance of healthcare-associated infections and the problem of underestimating cases: Results of sociological study in medical organizations of Khanty-Mansiysk Autonomous Okrug — Ugra

Prospects for Phagоtherapy of Bacterial Infections Associated with the Provision of Medical Care

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