Infections in children following chimeric antigen receptor T‐cell therapy for B‐cell acute lymphoblastic leukemia
Yonatan Diamond,
Maddie Gilsenan,
Stacie Shiqi Wang
et al.
Abstract:BackgroundCD19‐directed chimeric antigen receptor T‐cell (CAR‐T) therapy is transforming care for pediatric patients with relapsed or refractory B‐cell acute lymphoblastic leukemia (B‐ALL). There are limited pediatric‐specific data concerning the infection risks associated with CD19 CAR‐T therapy and the adequacy of current antimicrobial prophylaxis guidelines for these patients.MethodsWe describe the antimicrobial prophylaxis used and the types of infectious occurring in the first 100 days following CAR‐T the… Show more
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