Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

Naqvi, Iftikhar Haider; Mahmood, Khalid; Talib, Abu; Ubaid, Mohammad; Mahmood, Abdullah Al

doi:10.4236/ojgas.2014.43017

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…The majority of patients (77.8%) in this study were male; this male predominance is similar to an earlier study [14]. Mean age of 44.1 ±11 years among our patient population is in accordance with earlier published studies.…”

Section: Discussionsupporting

confidence: 92%

“…Mean age of 44.1 ±11 years among our patient population is in accordance with earlier published studies. Viral-related aetiology, hepatitis C (75.6%) and hepatitis B (15%) dominate in this study, which is comparable to previously published studies [14,19]. The overall mortality of 25.5% in our study group was congruent with the mortality rate of CLD patients of a previous study conducted by Naqvi et al in the same hospital [20].…”

Section: Discussionsupporting

confidence: 91%

“…Small shrunken liver and intra-abdominal varices with or without splenomegaly are important radiological parameters for cirrhosis. Liver cirrhosis was also proven on a histopathological basis, wherever required [14].…”

Section: Cirrhosismentioning

confidence: 99%

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The ability of the new ALBI scoring in predicting mortality, complications and prognostic comparison among cirrhotics

Naqvi

Talib

Mahmood

et al. 2019

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Introduction: Albumin-bilirubin (ALBI) is a newly devised scoring system for prognostication of liver cirrhosis. The ALBI has recently been validated and found superior to Child-Turcotte-Pugh score (CTP) and Model for End stage Liver Disease (MELD) in assessing severity of liver disease. Aim: To determine the ALBI score's mortality prediction among cirrhotics, associated complications and to compare its prognostic proficiency to that of MELD and CTP. Material and methods: The diagnostic accuracy of CTP, MELD and ALBI scores for mortality in hospitalized cirrhotic patients was determined by receiver operating characteristic curve (ROC) analysis. The areas under the ROC curve were calculated, with confidence intervals (CI) of 95%. The best cutoff values were ascertained with the greatest specificity and sensitivity. Results: The study showed overall in-hospital mortality of 25.5%. Median CTP score was 10.2 (IQR = 3) and area under curve (AUC) was 0.842 (95% CI: 0.817-0.868, p < 0.001) with sensitivity of 75.0% and specificity of 79.2%. Median MELD score was 20.9 (IQR = 7.2) and AUC was 0.836 (95% CI: 0.810-0.863, p < 0.001) with sensitivity of 76.6% and specificity of 76.7%. Median ALBI score was-1.1 (IQR = 1.0), and AUC of ALBI was 0.852 (95% CI: 0.826-0.879, p < 0.001) with sensitivity and specificity of 78.1%. Conclusions: The objective prognostication and easy utilization of ALBI make it a useful alternative to MELD and CTP and therefore favour its applicability in clinical practice. Further validations in large prospective cohorts are needed for prognostic value of ALBI in cirrhosis and its complications.

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Section: Discussionsupporting

confidence: 92%