Infections in hospitalised Russian children with AIDS

Abstract

The present chemoprophylaxis programme for opportunistic oral infections requires revision. Systems of microbiological surveillance and cross-infection control monitoring in relation to immunocompromised patients need to be developed to decrease the possibility of nosocomial transmission of potential pathogens between hospitalised children with AIDS, their mothers and health care providers.

Persistence of Oropharyngeal Candida albicans Strains with Reduced Susceptibilities to Fluconazole among Human Immunodeficiency Virus-Seropositive Children and Adults in a Long-Term Care Facility

“…The majority (54%) of the HIV-infected children were admitted to the Russia AIDS Centre with bacterial and fungal infections. The high prevalence of OPC in about half of them contributed to the decision to use azole drugs in their treatment (13). Fluconazole has been successful in treating OPC and esophageal candidiasis in HIV-infected patients (14,20,23), but its long-term use raises the possibility of the acquisition of resistance by the yeast Candida albicans (7,12,17,25) and the emergence of other Candida species, such as C. krusei and C. glabrata, with innately reduced susceptibilities to fluconazole (5,27).…”