Infections of Calves with Antigenic Variants of Bovine Herpesvirus 1 (BHV‐1) and Neurological Disease

Schudel, Alejandro A.; Carrillo, B. J.; Wyler, R.; Metzler, A. E.

doi:10.1111/j.1439-0450.1986.tb00036.x

Cited by 62 publications

(51 citation statements)

References 13 publications

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“…Comparative experiments of inoculation with BoHV-1 and BoHV-5 have been carried out in cattle [5,6,11,51,83,111]. After primary infection by intranasal inoculation, BoHV-1 and BoHV-5 replicate at the portal of entry in the respiratory mucosa [6].…”

Section: Bovine Herpesvirusmentioning

confidence: 99%

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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-Herpesviruses have mainly co-evolved with their hosts for millions of years. Consequently, different related host species may have been infected by various genetically related herpesviruses. Illustrating this concept, several ruminant alphaherpesviruses have been shown to form a cluster of viruses closely related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5, bubaline herpesvirus 1, caprine herpesvirus 1, cervid herpesviruses 1 and 2 and elk herpesvirus 1. These viruses share common antigenic properties and the serological relationships between them can be considered as a threat to BoHV-1 eradication programmes. BoHV-1 is a herpesvirus responsible for infectious bovine rhinotracheitis, which is a disease of major economic concern. In this article, the genetic properties of these ruminant alphaherpesviruses are reviewed on a comparative basis and the issue of interspecific recombination is assessed. The pathogenesis of these infections is described with emphasis on the host range and crossing of the host species barrier. Indeed, the non bovine ruminant species susceptible to these ruminant alphaherpesviruses may be potential BoHV-1 reservoirs. The differential diagnosis of these related infections is also discussed. In addition, available epidemiological data are used to assess the potential of cross-infection in ruminant populations. A better knowledge of these ruminant alphaherpesvirus infections is essential to successfully control infectious bovine rhinotracheitis.

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Section: Bovine Herpesvirusmentioning

confidence: 99%

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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“…BoHV-5 infection and neurological disease in bovine have been frequently observed in Brazil and Argentina, affecting mainly -but not exclusively -young animals (Carrillo et al 1983, Schudel et al 1986, Salvador et al 1998. BoHV-5 has been identified in outbreaks of neurological disease in cattle in several Brazilian states, including Rio Grande do Sul (Riet-Correa et al 1989, Weiblen et al 1989, Roehe et al1998, Mato Grosso do Sul (Salvador et al 1998) and Minas Gerais (Gomes et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Bovine herpesvirus type 5 (BoHV-5) formely classified as a subtype of BoHV-1 (BoHV-1.3) has been associated with fatal meningoencephalitis in cattle (Carrillo et al 1983, Schudel et al 1986), infertility and venereal disease in bovine (Kirkland et al 2009). BoHV-5 was detected as etiologic agent of apoptotic effect on in vitro produced bovine embryos in Brazil (Silva et al 2010a;Silva et al 2010b) and semen of healthy bull from Australia and Brazil (Diallo et al 2010, Oliveira et al 2011.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Search for Bovine Herpesvirus 5 (Bohv-5) in the Brain of Cattle Affected by Neurological Disease in Rio De Janeiro State

Pinto

Leite²,

Romijn³

et al. 2014

VR&R

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Bovine herpesvirus 5 (BoHV-5) is an important agent of meningoencephalitis in cattle and has been identified in outbreaks of neurological disease in several Brazilian states. However, no report of BoHV-5-associated neurological disease in Rio Janeiro state (RJ) has been published to date. This article reports a retrospective investigation for BoHV-5 performed in 146 brain specimens of cattle affected by neurological disease, submitted to the virology laboratory of the Empresa de Pesquisa Agropecuária do Estado do Rio de Janeiro (PESAGRO-RJ) between 1998 and 2001. Most specimens came from herds in the RJ state (130 or 89%) and a few from Minas Gerais counties (16 or 11%), close to the RJ border. All brain samples examined in this study were previously diagnosed negative for rabies virus. The specimens were submitted to PCR/nested-PCR for BoHV-5 sequences and virus isolation. From 146 analysed brains samples 48 (33%) were positive in at least one of the tests (PCR or virus isolation), 20 samples (14%) were positive in both assays, 19 samples (13%) were positive in Nested-PCR (n-PCR) and nine samples (6%) were characterized as BoHV-5 after virus isolation. The northeast region of the RJ contributed with most clinical specimens (92/146 or 63%) and presented the highest positivity (28/92 or 30%). These results demonstrated BoHV-5 association with neurological disease in bovine herds of RJ and MG and should therefore be included in differential diagnosis of neurological disease in cattle. The limitations of each of the diagnostic assays used here in led us to recommend the concomitant use of PCR and virus isolation to improve the sensitivity of the diagnosis of BoHV-5 infection.

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“…Like other alphaherpesviruses, BoHV-5 is able to establish a lifelong latent infection in sensory ganglia of infected animals (Caron et al 2002). The virus is endemic, at least in Brazil and Argentina, where severe outbreaks of neurological disease caused by BoHV-5 have been reported (Carrillo et al 1983, Schudel et al 1986, Salvador et al 1998, Gomes et al 2002.…”

Section: Introductionmentioning

confidence: 99%

“…Bovine herpesvirus type 5 (BoHV-5), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, is responsible for a fatal non-suppurative meningoencephalitis in cattle (Schudel et al 1986). Like other alphaherpesviruses, BoHV-5 is able to establish a lifelong latent infection in sensory ganglia of infected animals (Caron et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Experimental infection of rabbits with a recombinant bovine herpesvirus type 5 (BoHV-5) gI, gE and US9-negative

et al. 2009

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Bovine herpesvirus type 5 (BoHV-5) is a major cause of viral meningoencephalitis in cattle. The expression of different viral proteins has been associated with BoHV-5 neuropathogenesis. Among these, gI, gE and US9 have been considered essential for the production of neurological disease in infected animals. To evaluate the role of gI, gE and US9 in neurovirulence, a recombinant from which the respective genes were deleted (BoHV-5 gI-/gE-/US9-) was constructed and inoculated in rabbits of two age groups (four and eight weeks-old). When the recombinant virus was inoculated through the paranasal sinuses of four weeks-old rabbits, neurological disease was observed and death was the outcome in 4 out of 13 (30.7 %) animals, whereas clinical signs and death were observed in 11/13 (84.6%) of rabbits infected with the parental virus. In eight weeks-old rabbits, the BoHV-5 gI-/gE-/US9- did not induce clinically apparent disease and could not be reactivated after dexamethasone administration, whereas wild type BoHV-5 caused disease in 55.5% of the animals and was reactivated. These findings reveal that the simultaneous deletion of gI, gE and US9 genes did reduce but did not completely abolish the neurovirulence of BoHV-5 in rabbits, indicating that other viral genes may also play a role in the induction of neurological disease.

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Infections of Calves with Antigenic Variants of Bovine Herpesvirus 1 (BHV‐1) and Neurological Disease

Cited by 62 publications

References 13 publications

Ruminant alphaherpesviruses related to bovine herpesvirus 1

Ruminant alphaherpesviruses related to bovine herpesvirus 1

A Retrospective Search for Bovine Herpesvirus 5 (Bohv-5) in the Brain of Cattle Affected by Neurological Disease in Rio De Janeiro State

Experimental infection of rabbits with a recombinant bovine herpesvirus type 5 (BoHV-5) gI, gE and US9-negative

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