Infections of Cryptococcus species induce degeneration of dopaminergic neurons and accumulation of α-Synuclein in Caenorhabditis elegans

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases in the world. Misfolding of β-amyloid (Aβ) and α-synuclein (α-syn) and subsequent fibril formation are closely associated with the pathogenesis of AD and PD, respectively. Lentinan is a natural product commonly used in medicine and dietary supplements. It has potential antitumor, anti-inflammatory, and antiviral effects, but the underlying mechanism of its action on AD and PD remains unclear. In this study, lentinan inhibited the formation of Aβ and α-syn fibers in a dose-dependent manner and disrupted their mature fibers. Lentinan inhibited the conversion of Aβ and α-syn conformations to β-sheet-rich conformations. Additionally, lentinan protected Caenorhabditis elegans against damage caused by the accumulation of Aβ and α-syn aggregation and prolonged their lifespan. Notably, the beneficial effects of lentinan in AD and PD mice were also demonstrated, including ameliorating the cognitive and memory impairments in AD mice and behavioral deficits in PD mice. Finally, molecular interactions between lentinan and Aβ/α-syn pentamers were also explored using molecular docking.

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Forecasting the Parallel Interaction between Biosurfactants and Neurons: A Challenge for Clinicians

Rout,

Kumar Sahoo,

Kumar Pradhan

2024

Biosurfactants: A Boon to Healthcare, Agriculture &Amp; Environmental Sustainability

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Bacteria that are associated with human health are receiving a growing amount of attention, particularly those that inhabit the body's niches, such as the neural stem, neurons, gastrointestinal tract, skin, vaginal environment, and lungs. Biosurfactants are molecules that are both hydrophobic and hydrophilic, and receive little attention among the secondary metabolites that are released by microorganisms that are associated with human health. Not only do they serve as biosurfactants, but they also have the potential to control the microbiota through their antimicrobial activity and quorum sensing system in the complex human environment. They and the human body as a whole are shielded from microbial and fungal pathogens by these functions. Because of their diverse structures, biological functions, low toxicity, higher biodegradability, and adaptability, biosurfactants are now emerging as promising bioactive molecules. As a result, biosurfactants with antimicrobial activity, which are produced by bacteria that are associated with the human body and are related to everything that humans come into contact with, such as food, beverages, and comestics, are the subject of this comprehensive review.

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Infections of Cryptococcus species induce degeneration of dopaminergic neurons and accumulation of α-Synuclein in Caenorhabditis elegans

Cited by 3 publications

References 40 publications

Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson’s disease

Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson’s disease

Bifunctional Inhibitor Lentinan Inhibits Fibrillogenesis of Amyloid-β Protein and α-Synuclein and Alleviates Their Cytotoxicity: In Vitro and In Vivo Studies

Forecasting the Parallel Interaction between Biosurfactants and Neurons: A Challenge for Clinicians

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