Infections of the Ears, Nose, and Throat in Children With Primary Immunodeficiencies

Haddad, Joseph; Brager, Robert; Bluestone, Charles D.

doi:10.1001/archotol.1992.01880020030011

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…Yarmohammadi et al [15••] noted in their study that 81 of 113 patients with immune defi ciency had chronic otitis media, compared with 39 of 124 without immunodefi ciency (P < 0.001). Haddad et al [16] reviewed 75 hospitalized patients with immune defi ciencies and found that 80% had infections of the ears, nose, and throat. Cultures showed that the infections were consistent with those caused by community-acquired organisms.…”

Section: Otitis Media and Immunodefi Ciencymentioning

confidence: 99%

Otitis media as a presenting complaint in childhood immunodeficiency diseases

Wilson

Hogan²

2008

Curr Allergy Asthma Rep

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Otitis media is one of the most common childhood infections and may result from a variety of underlying problems. Suspicion of immunodeficiency should increase when ear infections are frequent; suppurative; unresponsive to antibiotics; caused by unusual organisms; or seen in the context of other frequent infections, severe eczema, or failure to thrive. Humoral immune deficiencies, particularly with an inability to make antibody to encapsulated organisms, are the immunodeficiencies most likely to cause increased otitis media. Immune system evaluation should concentrate on humoral immunodeficiency disorders, but the presenting history and physical findings also should be considered when designing the work-up. Treating the underlying immune deficiency is usually necessary to adequately control the ear infections.

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Section: Otitis Media and Immunodefi Ciencymentioning

confidence: 99%