Infections ostéoarticulaires à mycobactéries atypiques

Ziza, Jean-Marc; Desplaces, Nicole

doi:10.1016/j.rhum.2006.01.006

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…This Acid-Alcohol Bacillus Resistant (AFB) are not mandatory pathogens and for several years, the scientific community have not really shown interest in their study, but rather devoted to the study of TB epidemic. They were considered as saprophytic bacteria and their pathogenic potential are not recognized (Ziza and Desplaces, 2006). However, some mycobacteria such as Mycobacterium liflandii and Mycobacterium fortuitum produce toxins causing skin infections (Williamson et al, 2008;Kakou-Ngazoa et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Microbiological and molecular characterization of environmental mycobacterium strains isolated from the Buruli ulcer endemic and non-endemic zones in Cte dIvoire

Vakou¹,

Julien²,

Kakou-Ngazoa³

et al. 2016

Afr. J. Microbiol. Res.

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Mycobacterium ulcerans (MU), the causative agent of Buruli ulcer (BU), skin disease, is considered to be an environmental pathogen. The pathogenic virulence of MU is being linked to the expression of toxin called Mycolactone. Genetic analyses have shown the high diversity with variable number tandem repeats (VNTR) and mycobacterial interspersed repetitive units (MIRU) in M. ulcerans and in mycolactone producing Mycobacteria (MPMs). The purpose of this study is the molecular characterization of potentially pathogenic environmental mycobacteria strain, apart from the M. ulcerans, from aquatic environments in Côte d'Ivoire. A total of 473 samples were collected comprising of 251 water and 222 sediment based on sampling sites. The sediments were the most contaminated by mycobacteria with 60% as against 43.3% in water samples from the hyper endemic areas. In hypoendemic areas, water was the most contaminated with 53.57% against 43.24% in sediment. Microscopy by Ziehl-Neelsen-staining, and PCR diagnostics using IS2404 and KR were performed on strains. 20% fast growing isolated mycobacteria species including Mycobacterium mucogenicum, Mycobacterium peregrinum and Mycobacterium sp. was found carrying the IS2404 gene previously found in M. ulcerans. 9.23% of strains carry the ketoreductase (KR) genes, one of the synthesis of mycolactone enzymes. In terms of genetic analysis using the MIRU/VNTR, the MIRU 1 was the most amplified sequence, and LOCUS 6 less amplified; no known profile have been identified in this study. This study is the first step taken in order to understand different skin infections encountered in Côte d'Ivoire.

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Section: Introductionmentioning

confidence: 99%