Infections with the 2009 H1N1 influenza virus among hematopoietic SCT recipients: a single center experience

Rihani, Rawad; Hayajneh, Wail A.; Sultan, Iyad; Ghatasheh, Lubna; Abdel-Rahman, F.; Hussein, Nilly; Hussein, Ayad Ahmed; Al-Zaben, Abdulhadi; Sarhan, Mahmoud; Saad, Mustafa

doi:10.1038/bmt.2010.329

Cited by 24 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…this rate is high compared with the mortality from pandemic influenza in the general population, which was reported to be  0.5% [2]. In contrast, mortality rates in hematology/oncology patients with pH1N1 infection were reported at a wide range of estimates (0-22%) in different studies [5,22,[24][25][26][27][28]. In our study, almost all patients who died had pneumonia with progressive respiratory failure.…”

Section: Discussioncontrasting

confidence: 81%

Clinical presentations and outcomes of influenza infection among hematology/oncology patients from a single cancer center: pandemic and post-pandemic seasons

Saad

Hayajneh

Mubarak

et al. 2014

Scandinavian Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 81%

Clinical presentations and outcomes of influenza infection among hematology/oncology patients from a single cancer center: pandemic and post-pandemic seasons

Saad

Hayajneh

Mubarak

et al. 2014

Scandinavian Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Among the ILI patients, the age group of 5-15 years had the higher influenza positive rate while among the hospitalized patients the age groups 15 -< 50 years and 50 -< 65 years had a higher influenza positive rate compared with other age groups. The overall influenza detection rate in our (7)(8)(9)(10). Similar findings on influenza positive rates in comparable age groups were also found in Thailand, (11) Pakistan (12), Kenya (13) and Mongolia (14).…”

Section: Discussionsupporting

confidence: 74%

Influenza virus positivity nd circulating subtypes among cases of influenza-like illness nd severe acute respiratory infection, Egypt, 2012-2015

Refaey¹,

Amin²,

Labib³

et al. 2016

East Mediterr Health J

View full text Add to dashboard Cite

Information on the prevalence of influenza, circulating virus subtypes and seasonality is essential for selecting strains for annual vaccines and for planning immunization programmes. Data were obtained from the 13 sentinel surveillance sites throughout Egypt during 2012-2015. Laboratory-confirmed influenza was found in 13% of cases of influenza-like illness (ILI) and 18% of cases of severe acute respiratory infection (SARI); positivity for influenza was similar in cases of ILI and SARI in patients up to 15 years of age but increased for SARI and decreased for ILI in people aged ≥ 15 years. The most commonly observed influenza virus subtypes were B followed by A/ H3 in ILI cases, and A/H1N1 followed by B in SARI cases. The seasonality of influenza in ILI cases was NovemberFebruary, and that in SARI cases was November-March, peaking in January. RÉSUMÉ Les informations sur la prévalence de la grippe, les sous-types circulants du virus et la saisonnalité sont essentielles pour la sélection des souches destinées aux vaccins annuels, ainsi que pour la planification des programmes de vaccination. Les données sont issues des 13 sites sentinelles de surveillance à travers l'Égypte pour la période 2012-2015. La présence de la grippe a été confirmée en laboratoire pour 13 % des cas ‫واألمــراض‬ ‫باإلنفلونــزا‬ ‫الشــبيهة‬ ‫األمــراض‬ ‫حــاالت‬ ‫لــدى‬ ‫اجلوالــة‬ ‫الفرعيــة‬ ‫واألنــواع‬ ‫اإلنفلونــزا‬ ‫فريوســات‬ ‫إجيابيــة‬

show abstract

“…31 Taplitz et al showed that 52% of 27 patients with 2009 H1N1 had LRD, half of them required mechanical ventilation, and the overall influenza-associated mortality was 22%. 7 The reported number of patients in each of these and other recent reports [32][33][34] is relatively small, and the clinical outcomes of 2009 H1N1 vary somewhat differently in the different reports. Moreover, the disease severity of 2009 H1N1 compared with seasonal influenza was not described.…”

Section: Discussionmentioning

confidence: 97%

Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients

Choi

Boudreault

Xie

et al. 2011

Blood

126

147

View full text Add to dashboard Cite

It is not known whether pandemic 2009 influenza A/H1N1 (2009 H1N1) leads to more serious disease than seasonal influenza in hematopoietic cell transplant (HCT) recipients. In a retrospective study in HCT recipients with virologically proven influenza virus infection, a total of 161 HCT recipients (18 2009 H1N1, 103 seasonal influenza A, and 40 seasonal influenza B) were analyzed. In multivariable analyses, more patients with 2009 H1N1 had lower respiratory tract disease (LRD), hypoxemia, and prolonged viral shedding compared with seasonal influenza A. Seasonal influenza A and B outcomes were similar. There was no difference in overall and influenza-associated mortality among influenza virus types. Both early and delayed administration of antiviral therapy was shown to be beneficial in terms of decreased rates of development of LRD, although earlier intervention appeared to be more effective. Profound lymphopenia and lack of early antiviral therapy were associated significantly with LRD, hypoxemia, and death. High-dose corticosteroid treatment (≥ 1 mg/kg) given at the time of influenza diagnosis was associated with a reduced risk for mechanical ventilation. Thus, our data suggest that infection with 2009 influenza A/H1N1 resulted in more severe respiratory disease in HCT recipients compared with seasonal influenza.

show abstract

Infections with the 2009 H1N1 influenza virus among hematopoietic SCT recipients: a single center experience

Cited by 24 publications

References 21 publications

Clinical presentations and outcomes of influenza infection among hematology/oncology patients from a single cancer center: pandemic and post-pandemic seasons

Clinical presentations and outcomes of influenza infection among hematology/oncology patients from a single cancer center: pandemic and post-pandemic seasons

Influenza virus positivity nd circulating subtypes among cases of influenza-like illness nd severe acute respiratory infection, Egypt, 2012-2015

Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients

Contact Info

Product

Resources

About