Infectious and Noninfectious Corneal Ulcers in Ocular Graft-Versus-Host Disease: Epidemiology, Clinical Characteristics, and Outcomes

Sepulveda-Beltran, Paula A.; Carletti, Piero; Banda, Victor; Mulpuri, Lakshman; Levine, Harry; Amescua, Guillermo; Wang, Trent P.; Galor, Anat; Tonk, Rahul

doi:10.1016/j.ajo.2023.09.018

Cited by 2 publications

(2 citation statements)

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“…One review on the topic concluded that while central dendritic cell (DC) density could not distinguish eyes with and without oGVHD post‐HSCT, some eyes with oGVHD had very high DC density in the central cornea (>200 cells mm 2 ) 65 . Corneal ulcers, both due to inflammation and infection, can also be seen in coGVHD, with perforation as a potential visually threatening complication 44,83,84 . coGVHD can also impact the corneal nerves.…”

Section: Signs Of Ogvhd Versus Dedmentioning

confidence: 99%

“…65 Corneal ulcers, both due to inflammation and infection, can also be seen in coGVHD, with perforation as a potential visually threatening complication. 44,83,84 coGVHD can also impact the corneal nerves. While disparate findings have been noted with respect to nerve density in oGVHD, 85 the majority of studies found higher tortuosity (graded 0-4) in eyes with oGVHD (range across studies 2.2 ± 0.7 to 3.1 ± 0.7) compared to non-oGVHD post-HSCT (range across studies 1.3 ± 0.5 to 2.2 ± 0.5).…”

Section: Signs Of Ogvhd Versus Dedmentioning

confidence: 99%

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How does ocular graft‐versus‐host disease fit under the dry eye umbrella? A review

Kantor,

Tovar,

Wang

et al. 2024

Clinical Exper Ophthalmology

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Graft‐versus‐host disease (GVHD) is a systemic disease that can affect multiple organs as a consequence of an allogeneic haematopoietic stem cell transplant. One organ system that is often affected in GVHD is the eyes. Ocular GVHD (oGVHD) may involve various structures within the eye including the lacrimal glands, eyelids, conjunctiva, cornea, and nasolacrimal ducts, and is a source of morbidity in patients with GVHD. Common presenting features of GVHD overlap with dry eye disease (DED), including decreased tear production, epithelial disruption, and Meibomian gland dysfunction (MGD). In this review, we aim to compare oGVHD and DED to better understand the similarities and differences between the conditions, with a focus on pathophysiology, risk factors, clinical features, and treatments.

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Section: Signs Of Ogvhd Versus Dedmentioning

confidence: 99%