Infectious Bronchitis Virus Immune Responses in the Harderian Gland upon Initial Vaccination

Zegpi, R. A.; Breedlove, C.; Gulley, Stephen L.; Toro, Haroldo

doi:10.1637/0005-2086-64.1.92

Cited by 13 publications

(11 citation statements)

References 16 publications

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“…According to Saiada et al [91], the populations of (CD)4+, CD8+, and CD4+/CD8+ T-cells increased with age and this pattern does not change with IBV vaccination. Additionally, ArkDPI vaccines induced greater serum antibodies, B and T-helper cells (CD3+CD4+) and cytotoxic T cells (CD3+CD8+) on day-7 chicks compared with day-1-old chicks [92]. Another study showed that vaccinated chickens that presented high monocyte MHC II expression had the weakest vaccine-induced protection against IBV [93].…”

Section: Vaccine-mediated Immunity Against Ib and Nd 231 Vaccine-mmentioning

confidence: 99%

Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms

et al. 2021

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Infectious bronchitis (IB) and Newcastle disease (ND) are two important diseases of poultry and have remained a threat to the development of the poultry industry in many parts of the world. The immunology of avian has been well studied and numerous vaccines have been developed against the two viruses. Most of these vaccines are either inactivated vaccines or live attenuated vaccines. Inactivated vaccines induce weak cellular immune responses and require priming with live or other types of vaccines. Advanced technology has been used to produce several types of vaccines that can initiate prime immune responses. However, as a result of rapid genetic variations, the control of these two viral infections through vaccination has remained a challenge. Using various strategies such as combination of live attenuated and inactivated vaccines, development of IB/ND vaccines, use of DNA vaccines and transgenic plant vaccines, the problem is being surmounted. It is hoped that with increasing understanding of the immunological mechanisms in birds that are used in fighting these viruses, a more successful control of the diseases will be achieved. This will go a long way in contributing to global food security and the economic development of many developing countries, given the role of poultry in the attainment of these goals.

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Section: Vaccine-mediated Immunity Against Ib and Nd 231 Vaccine-mmentioning

confidence: 99%

Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms

et al. 2021

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“…Following IBV infection, memory B [ 104 ] and T cells [ 105 ] are formed and are present in peripheral blood and the spleen. Following IB vaccination, the number of B and T cells increases in the harderian gland [ 106 ]. Increased recruitments of CD4+ and CD8+ T cells in the trachea have also been shown following application of live IB vaccines [ 107 ].…”

Section: Vaccine Mediated Ib Controlmentioning

confidence: 99%

“…First, maternal antibodies could be protective against potential IBV infection during the first few days of life while early vaccination could enhance the decay of the maternal antibodies [ 110 ]. Second, early vaccination (i.e., Day 1 of age) induces poor B cell and T cell responses when compared to later vaccination (i.e., Day 7 of age) [ 106 ]. Third, IB vaccination at the day of age can induce severe vaccine reactions [ 113 ].…”

Section: Vaccine Mediated Ib Controlmentioning

confidence: 99%

“…Coinfection of host cells with live attenuated IB vaccines and wild type IBV can also result in genomic recombination contributing to the virus evolution [ 11 , 123 ] as well as mutations that can occur under the effect of immune pressure [ 124 , 125 , 126 ]. Although the global poultry industry practices hatchery vaccination against IB, Day 1 may not be the optimum time for vaccination in terms of inducing systemic and mucosal immune responses against IB [ 106 ] because of the developing immune system [ 127 ]. The availability of a limited number of licensed vaccines to choose in a geographical area is also a constraint.…”

Section: Vaccine Mediated Ib Controlmentioning

confidence: 99%

“…If the existing vaccines are not useful in optimizing vaccination strategies, it would also worth developing autogenous vaccines (inactivated) using characterized unique IBV isolates prevalent in a given geographical area in order to include in the existing vaccination regimes. Given the available scientific evidence against IB vaccination at the hatchery [ 106 , 110 ], it may also be appropriate to postpone the first IB vaccination to a barn vaccination done at seven days of age relying on maternal antibody response to protect the chickens during the first week of life [ 110 ]. There are numerous issues surrounding the use of live attenuated IB vaccines [ 11 , 99 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 ], and relying on inactivated vaccines can be an option, but they inherently lack the ability to induce mucosal immune response, which is critical for the control of IB [ 131 , 132 , 133 ].…”

Section: Vaccine Mediated Ib Controlmentioning

confidence: 99%

See 2 more Smart Citations

Infectious Bronchitis Coronavirus Infection in Chickens: Multiple System Disease with Immune Suppression

et al. 2020

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In the early 1930s, infectious bronchitis (IB) was first characterized as a respiratory disease in young chickens; later, the disease was also described in older chickens. The etiology of IB was confirmed later as being due to a coronavirus: the infectious bronchitis virus (IBV). Being a coronavirus, IBV is subject to constant genome change due to mutation and recombination, with the consequence of changing clinical and pathological manifestations. The potential use of live attenuated vaccines for the control of IBV infection was demonstrated in the early 1950s, but vaccine breaks occurred due to the emergence of new IBV serotypes. Over the years, various IBV genotypes associated with reproductive, renal, gastrointestinal, muscular and immunosuppressive manifestations have emerged. IBV causes considerable economic impacts on global poultry production due to its pathogenesis involving multiple body systems and immune suppression; hence, there is a need to better understand the pathogenesis of infection and the immune response in order to help developing better management strategies. The evolution of new strains of IBV during the last nine decades against vaccine-induced immune response and changing clinical and pathological manifestations emphasize the necessity of the rational development of intervention strategies based on a thorough understanding of IBV interaction with the host.

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Lymphatic and Hematopoietic System

Pendl,

Schmidt

2024

Pathology of Pet and Aviary Birds

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Infectious Bronchitis Virus Immune Responses in the Harderian Gland upon Initial Vaccination

Cited by 13 publications

References 16 publications

Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms

Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms

Infectious Bronchitis Coronavirus Infection in Chickens: Multiple System Disease with Immune Suppression

Lymphatic and Hematopoietic System

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