Infectious Causes of Acute Pancreatitis

Nesvaderani, Maryam; Eslick, Guy D.; Cox, Michael R.

doi:10.1016/b978-0-323-54843-4.00005-2

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…7,8,9 Biliary tract diseases and alcoholism account for 80%, while viral etiology accounts for less than 1%, of AP in adults and association with HZ is usually in immunocompromised individuals. 5,10 Although this association does not have its pathophysiology elucidated, the most accepted theory indicates that VZV latent in the posterior sensory nerve roots can reactivate as a visceral manifestation concomitant to a herpetic cutaneous lesion due to direct damage to the pancreatic acinar cell's membrane, leaking intracellular pancreatic enzymes and resulting in viral inclusion. 5,11 In the urgency reported, the clinical condition suggestive of AP led to a rapid stabilization which, complemented by imaging and laboratory tests, confirmed the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Unusual Acute Pancreatitis associated with Varicella-Zoster virus in immunocompetent

Júnior¹,

Júnior²,

Vale³

et al. 2023

Braz. J. Hea. Rev.

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Viral etiology represents less than 1% of acute pancreatitis (AP) in adults, even rarer if associated with varicella-zoster (VZ), having poor prognosis especially in immunocompromised. Reported 77-year-old male at emergency, with 24 hours of strong epigastric pain. Clinical signs with laboratory and imaging tests diagnosed AP. After clinical treatment, was discharged at 6th day. At follow up, exams excluded differential etiological diagnoses and, with the three mild annual herpes zoster crises, IgG strongly reactive for VZ virus and lumbosacral lesions, hypothesized herpetic pancreatitis. Herpetic AP in immunocompetent emphasizes thorough examination for etiological identification and better treatment targeting at emergency.

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Section: Discussionmentioning

confidence: 99%

Unusual Acute Pancreatitis associated with Varicella-Zoster virus in immunocompetent

Júnior¹,

Júnior²,

Vale³

et al. 2023

Braz. J. Hea. Rev.

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“…Alcohol use accounts for 25% to 35% of cases of acute pancreatitis in the United States [ 8 ]. Additional considerations include hypertriglyceridemia (> 1000 mg/dl) [ 9 ], hypercalcemia [ 10 ], medications [ 11 ], and infections [ 12 ]. As a complication of acute pancreatitis, a pseudocyst may develop over 4-6 weeks following the initial episode of pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

Severe, Complicated Pancreatitis With an Unclear Etiology

Nohomovich¹,

Shah²,

Hughes³

2023

Cureus

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Acute pancreatitis is an inflammatory process. There can be many causes of pancreatitis, which include alcohol or gallstones but can also be due to hypercalcemia, infections, or hypertriglyceridemia. Most cases of pancreatitis are mild and without complications. Severe cases of pancreatitis can cause complications, including organ failure. Pseudocysts are a rare complication of pancreatitis and may require management. We present a patient with severe acute pancreatitis with organ failure admitted to the intensive care unit, stabilized, and required subsequent management of a pseudocyst with cystogastrostomy with a lumen-apposing metal stent. The patient subsequently improved and is doing well today. Herein, we present an acute severe pancreatitis case report with an extensive workup complicated by pseudocyst development. We review pancreatitis causes, including rare causes and management.

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“…Species A Coxsackievirus have been associated with flaccid paralysis due to generalized myositis, while group B Coxsackievirus (CVB) have been related to spastic paralysis, owing to important muscle injury and degeneration of neuronal tissue. CVB also infects the heart, pleura, pancreas, and liver, causing pleurodynia, myocarditis, pericarditis, and hepatitis [4][5][6][7][8][9][10], while echovirus 9 has been described as a leading cause of childhood exanthems in the summer and fall, as well as an important cause of carditis [11].…”

Section: Introductionmentioning

confidence: 99%

Human Enterovirus B: Selective Inhibition by Quinoxaline Derivatives and Bioinformatic RNA-Motif Identification as New Targets

et al. 2022

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The Enterovirus genus includes many viruses that are pathogenic in humans, including Coxsackie viruses and rhinoviruses, as well as the emerging enteroviruses D68 and A71. Currently, effective antiviral agents are not available for the treatment or prevention of enterovirus infections, which remain an important threat to public health. We recently identified a series of quinoxaline derivatives that were provento be potent inhibitors of coxsackievirus B5, the most common and a very important human pathogen belonging to the enterovirus genus. We have shown how most active derivatives interfere with the earliest stages of viral replication, blocking infection. Considering the broad antiviral spectrum, a very attractive property for an antiviral drug, we aimed to investigate the antiviral activity of the most promising compounds against other Enterovirus species. Here, we investigated the susceptibility of a panel of representatives of Enterovirus genus (enterovirus A71, belonging to A species; coxsackieviruses B4 and B3;echovirus 9, belonging to B species; and enterovirus D68, belonging to D species) to quinoxaline inhibitors. We also tested cytotoxicity and selectivity indices of the selected compounds, as well as their effects on virus yield.We also investigated their potential mechanism of action by a time course assay. In addition, a bioinformatic analysis was carried out to discover potential new conserved motifs in CVB3 and CVB4 compared to the other enterovirus species that can be used as new targets.

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Infectious Causes of Acute Pancreatitis

Cited by 4 publications

References 66 publications

Unusual Acute Pancreatitis associated with Varicella-Zoster virus in immunocompetent

Unusual Acute Pancreatitis associated with Varicella-Zoster virus in immunocompetent

Severe, Complicated Pancreatitis With an Unclear Etiology

Human Enterovirus B: Selective Inhibition by Quinoxaline Derivatives and Bioinformatic RNA-Motif Identification as New Targets

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