Infectious causes of death in patients with rheumatoid arthritis: an autopsy study

Koivuniemi, Riitta; Leirisalo‐Repo, Marjatta; Suomalainen, R; Piirainen, Heikki; Paimela, Leena

doi:10.1080/03009740600556258

Cited by 27 publications

(16 citation statements)

References 13 publications

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“…From the non-RA patient group, those with chronic inflammatory rheumatic diseases were excluded. We have previously described in detail our patients and methods [18]. Patients with insufficient data or referred for autopsy from a hospital for traumatology and neurosurgery or a psychiatric hospital were excluded to avoid bias.…”

Section: Methodsmentioning

confidence: 99%

Amyloidosis is frequently undetected in patients with rheumatoid arthritis

Koivuniemi

Paimela

Suomalainen

et al. 2008

Amyloid

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Prevalence of AA amyloid in rheumatoid arthritis (RA) is still unclear. The objective of this retrospective study was whether dedicated re-examination of autopsy tissues from RA patients increases the detection rate of amyloid compared to routine examination. Amyloid was re-examined in tissue samples and detection rate compared with original reports of 369 consecutively autopsied RA patients and 370 non-RA patients matched for sex, age, and year of autopsy between 1952 and 1991. Re-examination of 90% of the 739 cases showed doubling of the prevalence of amyloid compared with the original reports: from 18 to 30% in RA and from 2 to 4% in non-RA patients. In RA patients, cardiac amyloid was as frequent as renal amyloid. In RA patients with amyloid at re-examination, amyloidosis had been diagnosed before autopsy in 37%, and these patients had more inflammation and longer disease duration than RA patients without amyloid. Only 56% of RA patients with renal amyloid were known to have proteinuria. In conclusion, this autopsy study shows that amyloid in RA is a common finding which remains frequently undetected. In patients with active and long-lasting RA, a systematic search for amyloid may enable early diagnosis of amyloidosis, which will require effective suppression of inflammation.

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Section: Methodsmentioning

confidence: 99%

Amyloidosis is frequently undetected in patients with rheumatoid arthritis

Koivuniemi

Paimela

Suomalainen

et al. 2008

Amyloid

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show abstract

“…По дан ным разных авторов, частота последних колеблется у больных РА от 30 до 43 % [1,2]. Летальность от пневмонии при РЗ в целом составляет 11-22 %, при РА -8-22 % [3].…”

Section: оригинальные исследованияunclassified

Assessment of clinical and immunological efficacy and safety of 23-valent pneumococcal vaccine in patients with rheumatoid arthritis

Наумцева¹,

Белов²,

Александрова³

et al. 2015

Pulʹmonologiâ (Mosk.)

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“…По данным евро-пейского многоцентрового исследования, инфекции встречались в 30% случаев среди причин смерти стацио-нарных больных СКВ, чаще всего это была пневмония. При РА летальность от пневмонии составила 8-22%, при ССД -12% [2,[50][51][52][53].…”

Section: пневмококковая инфекцияunclassified