Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus

Roos, Raymond P.; Stein, Steven; Ohara, Yoshikazu; Fu, Jianlin; Semler, Bert L.

doi:10.1128/jvi.63.12.5492-5496.1989

Cited by 76 publications

(47 citation statements)

References 12 publications

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“…5,7,[14][15][16] The full-length infectious cDNA were then constructed. [6][7][8][9] In addition, the 3-D structure was resolved by means of X-ray crystallography in the early 1990s. 17,18 The RNA genome is of positive sense and approximately 8100 nt long.…”

Section: Tmev: Properties and Biological Activitiesmentioning

confidence: 99%

Roles of two non-structural viral proteins in virus-induced demyelination

Himeda

Ohara

2011

Clinical and Experimental Neuroimmunology

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Theiler’s original (TO) subgroup strains of Theiler’s murine encephalomyelitis virus (TMEV) cause a milder polioencephalomyelitis followed by virus persistence and demyelination in the spinal cords of mice. TMEV‐induced demyelination is the representative of virus‐induced demyelination and serves as an excellent animal model for multiple sclerosis, because of the resembling pathological features. Two non‐structural viral proteins, leader (L) and L*, are reported to play an important role in TMEV biological activities. The present review will describe their properties, biological activities and how those proteins regulate TMEV‐persistence, which induces the demyelinating disease. (Clin. Exp. Neuroimmunol. doi: 10.1111/j.1759‐1961.2011.00021.x, September 2011)

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Section: Tmev: Properties and Biological Activitiesmentioning

confidence: 99%

Roles of two non-structural viral proteins in virus-induced demyelination

Himeda

Ohara

2011

Clinical and Experimental Neuroimmunology

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“…In order to identify the function of L*, we generated a mutant DA virus (from our wild type [wt] pDAFL full-length clone) 12 changing the initiation codon for L* from AUG to ACG, with no change in the amino acid sequence of the polyprotein; we called this virus DAL*-1 virus (Fig. 1).…”

Section: Viral Proteins Of Special Interest: L* Proteinmentioning

confidence: 99%

Pathogenesis of Theiler’s murine encephalomyelitis virus‐induced disease

Roos

2010

Clinical & Exp Neuroim

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Theiler’s murine encephalomyelitis virus (TMEV) is a member of the Cardiovirus genus of the Picornaviridae family. Interest in TMEV is at least partly related to the fact that the Daniels (DA) strain and other members of Theiler’s original (TO) subgroup induce an inflammatory demyelinating disease in which the virus persists for the life of the mouse. This disease resembles multiple sclerosis because of the similar pathology and because the immune system seems to play an important role in both. The present review describes features of TMEV and the importance of both virus persistence as well as the immune system in the pathogenesis of DA virus‐induced demyelinating disease. (Clin. Exp. Neuroimmunol. doi: 10.1111/j.1759‐1961.2010.00008.x, 2010)

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“…Despite the genetic variability that probably exists in vivo during infection, genetic studies on representative, cloned genomes and genetically engineered recombinants have begun to elucidate the viral genetic loci responsible for virulence, persistence, and demyelination (reviewed by Brahic et al, 1991). Complete nucleotide sequences of several different clones of GDVII, DA, and BeAn have now been determined (Ozden et al, 1986;Ohara et al, 1988;Pevear et al, 1987Pevear et al, , 1988McAllister et al, 1989;Roos et al, 1989;Fu et al, 1990). GDVII, DA, and BeAn are 90% identical in their nucleotide sequences and 95% identical in their amino acid sequences.…”

Section: B Theiler's Virusmentioning

confidence: 99%