Infectious Complication in 314 Patients after High-Dose Therapy and Autologous Hematopoietic Stem Cell Transplantation: Risk Factors Analysis and Outcome

Abstract

Patients at high risk of infection after autologous HSCT were identified as those with acute leukemia and those after conditioning with TBI, all with prolonged neutropenia. We suggest that newer prophylactic strategies should be administered to these groups of patients.

Autologous hematopoietic stem cell transplantation as late high-dose consolidation in adult patients with T-cell lymphoblastic leukemias: Results of a Russian multicenter study

“…Так, по данным ГНЦ МЗ России от 2007 г., частота эпизодов фебрильной лихорадки у больных после ауто-ТГСК составила 71%, при этом стоматит определяли у 100% больных, пневмонию-у 12%, сепсис -у 6% [22]. Польские исследователи приводят несколько бо`льшую частоту развития инфекций (92,3%) у больных после ауто-ТГСК [23]. Эти результаты свидетельствуют, что этап ауто-ТГСК является непростым и обусловливает необхо-димость выполнения жестких алгоритмов мониторинга, диагностики и лечения инфекционных осложнений.…”

Invasive Fungal Infections in Patients with Acute Leukemia and Hematopoietic Stem Cell Transplant Recipients

“…In HCT recipients the risk for IA significantly depends on the type of transplant (ASCT versus allo-HCT); conditioning regimen (myeloablative, nonmyeloablative, reduced intensity); stem cell graft source (related, unrelated, haploidentical, umbilical cord, HLA matched or mismatched, T-cell depleted); post-transplant interventions (salvage chemotherapy, prolonged treatment with glucocorticoids and anti-rejection medications); and the development of post-transplant complications, particularly GVHD [43][44][45]. Overall risk for IA is low in ASCT represents (1-2%) because there is only a brief period of immunosupression and neutropenia in these patients [46]. In allo-HCT recipients, the risk for IA is substantially higher with a trimodal incidence distribution [32,[47][48].…”

Hematolojik malignite nedeniyle kemoterapi verilen hastalarda febril nötropenik atak gelişimi için risk faktörleri

“…In addition, many other risk factors (such as age, the chemotherapy protocol, prophylactic antifungal treatment, gastrointestinal system sterilization, the neutrophil count during the attack, and thrombocytopenia) were identified as risk factors in many studies (1)(2)(3)(4)(5)(6)(7).…”

“…Neutropenia was defined as a neutrophil count of <500 cells/mm 3 . FNA was defined as any febrile period during the neutropenic period.…”