Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series

Costa, Rafael Lessa da; Moreira, José; Lorenzo, Andrea De; Lamas, Cristiane da Cruz

doi:10.1186/s12906-018-2394-3

Cited by 63 publications

(40 citation statements)

References 20 publications

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“…This new search retrieved eight publications and seven of them were excluded from the assessment because referred to previous EFSA FEEDAP opinions regarding other S. cerevisiae based products. One publication referred to reported cases of human infections by S. cerevisiae mainly on immune suppressed patients, which are well known and unrelated to the additive under assessment (Costa et al, 2018).…”

Section: Safetymentioning

confidence: 99%

Assessment of the application for renewal of the authorisation of Actisaf® Sc 47 (Saccharomyces cerevisiae CNCM I‐4407) as a feed additive for calves for rearing

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of Actisaf ® Sc 47 ( Saccharomyces cerevisiae CNCM I‐4407) as a zootechnical additive for calves for rearing. The applicant has provided evidence that the additive currently in the market complies with the existing conditions of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concludes that the additive remains safe for calves for rearing, consumers and the environment under the authorised conditions of use. The additive is not a skin or eye irritant. In the absence of data, no conclusions can be drawn on the dermal sensitisation potential of the additive. Inhalation exposure is unlikely. The present application for renewal of the authorisation did not include a proposal for amending or supplementing the conditions of the original authorisation that would have an impact on the efficacy of the additive. Therefore, there was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.

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Section: Safetymentioning

confidence: 99%

Assessment of the application for renewal of the authorisation of Actisaf® Sc 47 (Saccharomyces cerevisiae CNCM I‐4407) as a feed additive for calves for rearing

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

View full text Add to dashboard Cite

show abstract

“…-Be cautious regarding the use of probiotics, as they may result in no effect or in deleterious effects, especially in immunossuppressed or severely ill patients (16).…”

Section: Potential Beneficial Measures In Nutrition and Antibiotic Usmentioning

confidence: 99%

The gut and the heart: a concise narrative review

Lamas¹

2019

HVT

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Foods have a wider role besides simply satisfying hunger, and the gut may be the source of several diseases. The human gut is populated by 100 trillion microorganisms and the most abundant phyla are the Firmicutes ( 60 a 80%), such as the lactobacilli, and the Bacteroidetes ( 20 a 40%), such as the gender Bacteroides.The obesity epidemics may be related to the constant availability of food, less physical exercise, and influences on the gut microbiota such as type of food ingested (low fiber, high calorie, and high fat). The beneficial effects of the gut microbiota result partly from products derived from the fermentation of nondigestible carbohydrates (fibers), which generate short chain fatty acids, which in turn influence hormones that stimulate insulin secretion, improve insulin receptor sensitivity, promote satiety and inhibit glucagon secretion. Obese individuals have increased intestinal permeability and LPS release may promote, through metabolic endotoxaemia, an inflammatory state, such as seen in type II diabetes mellitus and obesity. Chronic heart failure results in a decreased perfusion of the gastrointestinal tract, with edema, dysmotility and malabsorption, which facilitates LPS release, which may induce negative inotropic effects, myocardial hypertrophy, fibrosis and apoptosis via tumor necrosis factor (TNF)-α, interleukin (IL)-1 and IL-6. Trimethylamine-N-oxide (TMAO) is a microbiota derived metabolite and is pro-atherogenic. Eating healthy and making judicious use of antibiotics may promote cardiovascular health via effects on the gut microbiota.

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“…and Pediococcus spp. were involved as causative agents, among other probiotic organisms of common use [37].…”

Section: Introductionmentioning

confidence: 99%

Members of the Lactobacillus Genus Complex (LGC) as Opportunistic Pathogens: A Review

2019

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Microorganisms belonging to the Lactobacillus genus complex (LGC) are naturally associated or deliberately added to fermented food products and are widely used as probiotic food supplements. Moreover, these bacteria normally colonize the mouth, gastrointestinal (GI) tract, and female genitourinary tract of humans. They exert multiple beneficial effects and are regarded as safe microorganisms. However, infections caused by lactobacilli, mainly endocarditis, bacteremia, and pleuropneumonia, occasionally occur. The relevance of Lactobacillus spp. and other members of the LGC as opportunistic pathogens in humans and related risk factors and predisposing conditions are illustrated in this review article with more emphasis on the species L. rhamnosus that has been more often involved in infection cases. The methods used to identify this species in clinical samples, to distinguish strains and to evaluate traits that can be associated to pathogenicity, as well as future perspectives for improving the identification of potentially pathogenic strains, are outlined.

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Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series

Cited by 63 publications

References 20 publications

Assessment of the application for renewal of the authorisation of Actisaf® Sc 47 (Saccharomyces cerevisiae CNCM I‐4407) as a feed additive for calves for rearing

Assessment of the application for renewal of the authorisation of Actisaf® Sc 47 (Saccharomyces cerevisiae CNCM I‐4407) as a feed additive for calves for rearing

The gut and the heart: a concise narrative review

Members of the Lactobacillus Genus Complex (LGC) as Opportunistic Pathogens: A Review

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