Infectious complications in children conditioned for allogeneic haematopoietic stem cell transplantation with reduced intensity conditioning or with treosulfan-based reduced toxicity preparative regimen

Prospective Epstein–Barr virus‐related post‐transplant lymphoproliferative disorder prevention program in pediatric allogeneic hematopoietic stem cell transplant: virological monitoring and first‐line treatment

“…Moreover, high EBV DNAemia levels were observed in 37.5% of the recipients who developed post-transplant EBV infection. We identified that SAA, unrelated donor, the RIC regimen and, to a lesser extent, in vivo T-cell depletion with ATG were associated with higher frequencies of EBV infection with high viral load, pointing to the same results recognized by other investigators (24,26,27,(29)(30)(31)(32). The duration between disease diagnosis and type of treatments before transplant was evaluated (data not shown).…”

“…Finally, as reported in other studies , EBV infection with high viral load appears to be significantly related in children following RIC HSCT, particularly with selective depletion of recipient T cells with ATG relative to B cells. This finding probably reflects the profound immunosuppression following RIC HSCT, together with the incomplete ablation of recipient‐derived B cells.…”

Myeloablative therapy against high risk Ewing's sarcoma: A single institution experience and literature review

“…Results are worse in patients with metastases to the bone and/or bone marrow (BM). Recognition of this problem, combined with improvements in supportive measures 6 that decrease toxicity risks, 7 has led to a great interest in applying chemotherapy dose intensification strategies to improve the prognosis of this subset of patients. Autologous stem cell transplantation (ASCT) has been employed as consolidation therapy for children with a variety of high-risk solid tumors.…”