Infectious disease

Wellehan, James F. X.; Lierz, Michael; Phalen, David N.; Raidal, Shane R.; Styles, Darrel K.; Crosta, Lorenzo; Melillo, Alessandro; Schnitzer, Petra; Lennox, Angela M.; Lumeij, J. T.

doi:10.1016/b978-1-4557-4671-2.00011-2

Cited by 16 publications

(8 citation statements)

References 391 publications

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“…This variation in the physical parameters appears to be intricately linked to the life history traits of viruses (multiplication rate, viability, and mode of transmission/entry into host cell) that are ultimately related to their life cycle. In most RNA viruses, the inherent error-prone replication without proof-reading imposes a constraint on the genome size (Wellehan et al, 2016). In addition, there appear to be two mechanistically different pathways for capsid assembly in RNA viruses that could influence the capsid size (Perlmutter et al, 2014;Chevreuil et al, 2018;Valbuena et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Scaling relation between genome length and particle size of viruses provides insights into viral life history

Chaudhari¹,

Inamdar²,

Kondabagil³

2021

iScience

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Section: Resultsmentioning

confidence: 99%

Scaling relation between genome length and particle size of viruses provides insights into viral life history

Chaudhari¹,

Inamdar²,

Kondabagil³

2021

iScience

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“…Herpesviruses have adapted to their endemic hosts over millions of years, and relatively mild clinical disease with latency is a characteristic of endemic herpesviral infection. In aberrant hosts, the complex balance needed for latency is not present, and rapidly fatal fulminant disease is often seen, as is seen with CoHV1 in GHOW . The clinical presentation of this animal is more consistent with an endemic herpesvirus.…”

Section: Discussionmentioning

confidence: 75%

“…Herpesviruses exhibit a high degree of host specificity and sequence conservation and are often thought to have co‐diverged with their host species. While endemic hosts may only experience mild disease despite life‐long infection, nonadapted individuals can develop rapidly fatal fulminant disease …”

Section: Introductionmentioning

confidence: 99%

A novel herpesvirus associated with chronic superficial keratitis and proliferative conjunctivitis in a great horned owl (Bubo virginianus)

Gleeson

Moore

Edwards

et al. 2018

Veterinary Ophthalmology

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An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine. Histopathologic evaluation of a conjunctival biopsy revealed epithelial features suspicious for viral cytopathic changes and intranuclear structures suspicious for viral inclusions, suggestive of a possible viral-induced papillomatous conjunctivitis. A novel alphaherpesvirus, referred to as Strigid Herpesvirus 1 (StrHV1), was identified using PCR and gene sequencing. This case represents a new clinical manifestation of a previously unreported herpesvirus in the GHOW. Identification of the herpes virus was critical to administration of appropriate therapy and resolution of the conjunctivitis, and corneal epithelial debridement promoted resolution of the chronic corneal epithelial defect.

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“…Therefore, infectious diseases can be defined as disorders caused by pathogenic microorganisms, such as viruses, bacteria, parasites, or fungi, which can be directly or indirectly spread from one individual to another [105]. For this reason, they are often considered as a war against microbes [106].…”

Section: Diagnosis Of Infectious Diseasesmentioning

confidence: 99%

Magnetic Particles for Advanced Molecular Diagnosis

2019

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Molecular diagnosis is the field that aims to develop nucleic-acid-based analytical methods for biological markers and gene expression assessments by combining laboratory medicine and molecular genetics. As it gradually becomes a clinical reality, molecular diagnosis could benefit from improvements resulting from thorough studies that could enhance the accuracy of these methods. The application of magnetic particles in molecular diagnosis tools has led to tremendous breakthroughs in terms of specificity, sensitivity, and discrimination in bioassays. Therefore, the aim of this review is to highlight the principles involved in the implementation of magnetic particles for sample preparation and targeted analyte isolation, purification, and extraction. Furthermore, the most recent advancements in the area of cancer and infectious disease diagnosis are presented, with an emphasis on screening and early stage detection.

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Infectious disease

Cited by 16 publications

References 391 publications

Scaling relation between genome length and particle size of viruses provides insights into viral life history

Scaling relation between genome length and particle size of viruses provides insights into viral life history

A novel herpesvirus associated with chronic superficial keratitis and proliferative conjunctivitis in a great horned owl (Bubo virginianus)

Magnetic Particles for Advanced Molecular Diagnosis

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