Infectious Disease Imaging

Lungren, Matthew P.; Peper, Jeroen P. C.; Ordoñez, Alvaro A.; Jain, Sanjay

doi:10.1007/978-1-4614-0604-4_16

Cited by 2 publications

(1 citation statement)

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“…Therefore, clinicians frequently use conventional radiological techniques such as computerized tomography (CT), magnetic resonance imaging (MRI), X-ray, and ultrasound, to aid in the diagnosis and localization of deep-seated infections. 9 However, these techniques rely on the presence of structural abnormalities in tissues and organs caused by the infection and/or inflammatory response of the host and are unable to reliably differentiate infection from inflammation or oncologic processes. To try to address this clinical challenge, multiple molecular imaging techniques have been developed to detect bacteria in vitro , in animal models, and for clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Pathogen-Specific Bacterial Imaging in Nuclear Medicine

Ordoñez

Jain

2018

Seminars in Nuclear Medicine

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When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques often rely on tissue biopsies to obtain clinical samples which can be expensive, dangerous, and has the potential of sampling bias. Moreover, these procedures and results can take several days and may not always provide reliable information. This combination of time and effort required for proper antibiotic selection has become a barrier leading to indiscriminate broad-spectrum antibiotic use. Exposure to nosocomial infections and indiscriminate use of broad-spectrum antibiotics are responsible for promoting bacterial drug-resistance leading to substantial morbidity and mortality, especially in hospitalized and immunosuppressed patients. Therefore, early diagnosis of infection and targeted antibiotic treatments are urgently needed to reduce morbidity and mortality caused by bacterial infections worldwide. Reliable pathogen-specific bacterial imaging techniques have the potential to provide early diagnosis and guide antibiotic treatments.

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Section: Introductionmentioning

confidence: 99%