Infectious disease markers in blood donors at central referral hospital, Gangtok, Sikkim

Adhikari, Luna; Bhatta, Dharmraj; Tsering, Dechen C; Sharma, Dhruva; Pal, Ranabir; Gupta, Amlan

doi:10.4103/0973-6247.59392

Cited by 18 publications

(16 citation statements)

References 2 publications

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“…1,2,[27][28][29][30][31] On the contrary, seroreactivity of Syphilis was higher in replacement donors compared to voluntary donors which was supported by finding of some authors. 4,15,36 Seroprevalence of Syphilis was least in 18-25 year age group and then increased up to 55 years, followed by decline in age group of 56-65 years which were similar to findings of Karmakar et al 26 Although Syphilis is known for increasing susceptibility to other TTI, We didn't found any co-infection with HIV, HCV or Malaria except HBV (2.08%) in our study. Kumar et al reported Syphilis co-infection rate with HBV (3.7%) and with HIV (2.9%), 25 while Makroo et al found 3% for HIV, 18.7% for HCV.…”

Section: Discussionsupporting

confidence: 89%

“…4,13,14,32,33 Seroprevalence rate of Syphilis among blood donors ranged from 0% to 12.7% across the world 3,4,13,14,[19][20][21][32][33][34][35] (Table 4). In India it ranges from 0.03% to 2.6% in different states 11,15,[22][23][24][25][26][27][28][29][30][31]36,37 (Table 5). This range of variation may be due to geographical locations, lifestyle of respective population, donor selection criteria, age range of donors, sample sizes, study period, variable sensitivity & specificity of test kits and different socio-cultural practices like sexual behaviour, marriage practices etc.…”

Section: Discussionmentioning

confidence: 99%

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Syphilis in blood donors: Pre-transfusion serological screening by Rapid Plasma Reagin (RPR) Test at the blood bank of a Teaching Medical Institute in North Gujarat, India

2020

IJPO

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Introduction: Apart from sexual transmission, blood transfusion is the other common route of transmission for Syphilis. Aims & Objectives: To study prevalence of seroreactivity of Syphilis in blood donors of our geographical area in relations to their different demographic variables and co-infection with other TTI (Transfusion Transmissible Infections). Materials & Methods:Records of all blood donations and TTI testing at the blood bank of our teaching medical institute from April 2012 to March 2016 were reviewed retrospectively. Data of all blood donors who were seroreactive for Syphilis were analysed in relations to their different demographic variables and results were interpreted accordingly. Results: Out of 6633 registered blood donors, 6360 were accepted including 6246 males (98.2%) and 114 females (1.8%) with 5597 Voluntary (88%) and 763 Replacement (12%) donors. Out of 6360, total 48 donors (0.75%) were found seroreactive for Syphilis including 45 males (0.72%) and 3 females (2.63%) with 39 Voluntary (0.70%) and 9 Replacement (1.18%) donors. Prevalence of Syphilis is comparatively high among age group of 46-55 years. Coinfection of Syphilis with HBV was 2.08%, while any co-infection with HIV, HCV and Malaria was not found. Conclusion: Seroprevalence of Syphilis in blood donors in present study is 0.75%. Even though trend of syphilis is declining, screening of blood donors should be continued to avoid the transmission of undiagnosed and untreated syphilis. Considering the limitations of RPR test, more sensitive and specific tests like Recombinant antigen based EIA and Rapid ImmunoChromatographic Strip (ICS) should be used if available and feasible.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Syphilis in blood donors: Pre-transfusion serological screening by Rapid Plasma Reagin (RPR) Test at the blood bank of a Teaching Medical Institute in North Gujarat, India

2020

IJPO

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“…This is comparable to the study done by Matee et al . [ 7 ] The seroprevalence of the HIV, HBV, HCV, and syphilis were 0.26%, 1.30%, 0.25%, and 0.28%, respectively which is comparable with other studies such as Adhikari et al .,[ 8 ] Anjali et al .,[ 3 ] Pallavi et al .,[ 4 ] Pahuja et al .,[ 9 ] Arora et al .,[ 10 ] Bhattacharya et al .,[ 11 ] and Srikrishna et al . [ 12 ] as shown in Table 3 .…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of transfusion transmitted infections in healthy blood donors: A 5-year tertiary care hospital experience

et al. 2017

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INTRODUCTION:Transfusion transmitted infections (TTIs) can cause threat to bloody safety as blood transfusion is an important mode of transmission of TTI to the recipient, hence, to prevent transmission of these diseases, screening tests on blood bags is an important step for blood safety.AIM:This study was undertaken with the aim of determining the seroprevalence of TTI in healthy blood donors in a tertiary care blood bank.MATERIALS AND METHODS:A retrospective study was carried out over a period of 5 years from January 2007 to December 2011. Serum samples were screened for hepatitis B surface antigen (HBsAg), antibodies to human immunodeficiency virus (HIV) Type 1 and 2, hepatitis c virus (HCV) and syphilis using enzyme-linked immunosorbent assays with the third generation kits and venereal disease research laboratory test, respectively.RESULTS:A total of 76,653 healthy donors were included out of which majority of donors were male (91.79%). The overall seroprevalence of HIV, HBsAg, HCV, and syphilis were 0.26%, 1.30%, 0.25%, and 0.28%, respectively.CONCLUSION:Methods to ensure a safety blood supply should be encouraged. For that, screening with a better selection of donors and use of sensitive screening tests including nucleic acid testing technology should be implemented.

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“…4,6,7 In another study, a higher prevalence of HIV seropositivity has been documented among voluntary blood donors also. 21 This suggests that, there is a high degree of variability of HIV seroreactivity among voluntary and replacement donors of different geographic locales. The prevalence of HIV seropositivity among blood donors from urban areas was found to be 0.21% only, while that from rural areas was 0.41% (Table 1).…”

Section: Resultsmentioning

confidence: 99%

HIV seropositivity and its ethical implications for blood donors in a tertiary care hospital of Andhra Pradesh

IS¹,

KV²,

Yashovardhan³

et al. 2012

JCSR

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Background: Blood is a scarce, but lifesaving resource; it is also the most efficient vehicle for the transmission of human immunodeficiency virus (HIV). Hence there is a need for accurate screening of HIV among blood donors. The present study was designed to assess the seroprevalence of HIV, among the blood donors in a tertiary care hospital, Andhra Pradesh. Methods: Prospective study over a period of one year. A total of 5,329 donor blood samples were screened for HIV status using enzyme linked immunosorbent assay. The reactive samples have been tested again twice using different kits. The samples reactive all three times were considered positive. The samples which were positive only in first test were labelled as false positive. Results: Out of 5,329 blood donors screened, 27 (0.5%) were initially reactive and 15 (0.28%) were reactive after triple testing. Conclusions: Our study showed similar HIV seroprevalence as that reported by National acquired immunodeficiency syndrome control organization statistics. But there was a mild increase in HIV prevalence among rural donors in our region compared to the urban donors.

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Infectious disease markers in blood donors at central referral hospital, Gangtok, Sikkim

Cited by 18 publications

References 2 publications

Syphilis in blood donors: Pre-transfusion serological screening by Rapid Plasma Reagin (RPR) Test at the blood bank of a Teaching Medical Institute in North Gujarat, India

Syphilis in blood donors: Pre-transfusion serological screening by Rapid Plasma Reagin (RPR) Test at the blood bank of a Teaching Medical Institute in North Gujarat, India

Seroprevalence of transfusion transmitted infections in healthy blood donors: A 5-year tertiary care hospital experience

HIV seropositivity and its ethical implications for blood donors in a tertiary care hospital of Andhra Pradesh

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