Infectious Diseases

Benirschke, Kurt; Kaufmann, Peter

doi:10.1007/978-1-4757-4193-3_24

Cited by 9 publications

(4 citation statements)

References 426 publications

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“…Clinical data on placental involvement in intrauterine HSV infections are scarce. Case reports have been presented both in favor of a hematogenous transplacental infection (grossly unremarkable placentas with areas of villous necrosis) and of ascending infections (chorioamnionitis without signs of villitis), as recently reviewed by Benirsche and Kaufmann [1990], and both forms may occur. Evaluation of their relative importance awaits further studies from the clinic.…”

Section: Discussionmentioning

confidence: 99%

“…HSV represents several types of risk to the fetus. HSV has been detected in abortion material [Benirsche and Kaufmann, 1990;Brown et al, 19871 and primary symptomatic genital HSV infection prior to week 20 of gestation has been associated with an increased rate of spontaneous abortion [Nahmias et al, 19711. Another complication of maternal infection is preterm labor and fetal growth retardation [Nahmias et al, 19711.…”

Section: Discussionmentioning

confidence: 99%

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Herpes simplex virus infection of cultured human term trophoblast

Nørskov‐Lauritsen

ABoagye-Mathisen

Juhl

et al. 1992

Journal of Medical Virology

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Mononuclear trophoblast cells were isolated from term placentas of uncomplicated pregnancies, purified to homogeneity by negative immunomagnetic separation using monoclonal antibodies to the major histocompatibility complex, and challenged with herpes simplex virus (HSV). The cultures were highly susceptible to virus-induced cytopathic effect as evidenced by cytopathic alteration and inhibition of human chorionic gonadotropin (hCG) secretion. Both HSV I and II underwent a full replicative cycle in the trophoblast, although the production of progeny virus was 10-100 times less than that obtained with placental fibroblasts or choriocarcinoma cells. The permissiveness was independent of in vitro syncytial differentiation of the trophoblast. The results suggest that the trophoblast layer may be involved in intrauterine HSV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Herpes simplex virus infection of cultured human term trophoblast

Nørskov‐Lauritsen

ABoagye-Mathisen

Juhl

et al. 1992

Journal of Medical Virology

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“…Studies have been done to determine the role and the invasive abilities of microorganisms in the aetiology and pathogenesis of chorioamnionitis (8,11,12,16). The microorganisms most commonly isolated from the placenta are group B streptococci (GBS), Staphylococcus epidermidis, Escherichia coli and Mycoplasma species, mainly Ureaplasrna urealyticum (3,15).…”

mentioning

confidence: 99%

A case control study of chorioamniotic infection and histological chorioamnionitis in stillbirth

Folgosa

González

Osman

et al. 1997

APMIS

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case control study of chorioamniotic infection and histological chorioamnionitis in stillbirth. APMIS 105: 329-336, 1997. In order to elucidate the role and aetiology of chorioamnionitis in stillbirth a case referent study was carried out in 58 pregnant women with late foetal death (cases) and in 58 pregnant women at term with live foetus (referents) matched for age and parity in Maputo Mozambique. Samples from women, stillborns and liveborns, were collected for microbiological and histological assessment. Histological chorioamnionitis was diagnosed in 96% of the cases and in 67%) of the referents (OR=13.5; 95% CI: 2.9-123.9). Escherichiu coli was the species most frequently isolated in stillborns; in 14/16 (88Yo) cases it was isolated from intracardiac fluid. E. coli was associated with chorioamnionitis in 28% of the stillborns as compared to 5'%) of the referents (OR=6.9; 95% CI: 1.4-65.4). No group B streptococci were recovered from any placenta or newborn. Vasculitis was present in 12 (21%) cases and in 3 (5%) referents (OR=4.8; 95%, CI: 1.2-27.7). Histological chorioamnionitis was thus associated with stillbirth. E. coli was common in stillborns. The presence of vasculitis in one fifth of the stillborns indicated that the foetus was alive at the onset of infection.

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“…Rarely it is acquired by amniocentesis, sampling from chorionic villi, amnioscopy, percutaneous umbilical blood sampling, or intrauterine fetal transfusion [1]. Syphilis, listeriosis, toxoplasmosis and cytomegalovirus infections are known to cause hematogenous placental infections [2], but they are rapidly decreasing in number in Japan.…”

mentioning

confidence: 99%

Intrauterine Infection: Pathological Study on Chorioamnionitis and Villitis of Unknown Etiology

et al. 1994

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Abstract.Twenty-five placentae between 24 and 41 gestational weeks showing signs of intrauterine infection were studied pathologically.The placentae with chorioamnionitis at less than 33 gestational weeks had thick amniotic layers due to infiltration by polymorphonuclear leucocytes (PMNL) and fibrin deposits.Umbilical cords also showed signs of infiltration and occasional calcification.The main cause of chorioamnionitis in these cases is ascending bacterial intrauterine infection had villitis with cholangiosis and dysmature villi in 6 placentae. The clarification of these infectious processes is difficult, and they are mostly diagnosed as villitis of unknown etiology (VUE). Autopsy data are useful for the clarification of infectious pathology in stillborn cases.

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Infectious Diseases

Cited by 9 publications

References 426 publications

Herpes simplex virus infection of cultured human term trophoblast

Herpes simplex virus infection of cultured human term trophoblast

A case control study of chorioamniotic infection and histological chorioamnionitis in stillbirth

Intrauterine Infection: Pathological Study on Chorioamnionitis and Villitis of Unknown Etiology

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