Infectious Diseases and Clinical Complications During Treatment in CLL

Paraplegia Caused by Infectious Agents; Etiology, Diagnosis and Management

“…A combination of zidovudine and lamivudine has been used for treatment, but no clinical improvement was seen, and there was no effect on HTLV-I proviral load or immunologic markers [100]. The most commonly antiviral agents used for treatment of CMV are: ganciclovir, foscarnet, cidofovir, valganciclovir and valaciclovir [101]. Ganciclovir has been used in patients with CMV polyradiculopathy successfully [53].…”

“…Voriconazole has been used to treat aspergillosis [58]. The gold standard of systemic antifungal treatment is voriconazole, which has been proved to be significantly superior to conventional amphotericin B. Liposomal amphotericin B appears to be a suitable alternative for primary treatment, while caspofungin, amphotericin B lipid complex or posaconazole have shown partial or complete response in patients who had been refractory to or intolerant of primary antifungal therapy [101]. Itraconazole is more frequently used in immunosuppressed patients who are able to take oral therapy and for use as sequential oral therapy [102].…”

“…Itraconazole is more frequently used in immunosuppressed patients who are able to take oral therapy and for use as sequential oral therapy [102]. Options for initial therapy for invasive Candida infections include fluconazole, echinocandin compounds or liposomal amphotericin B. Voriconazole is the secondary alternative treatment [101]. Amphotericin B, caspofungin or posaconazole are used for treatment of Zygomycosis [103,104].…”