Infectious Disorders of the Lower Genital Tract

Soong, Thing Rinda; Granter, Scott R.; Haefner, Hope K.; Laga, Alvaro C.

doi:10.1016/b978-0-323-44732-4.00004-2

Cited by 2 publications

(2 citation statements)

References 217 publications

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“…Este título de bajo nivel suele ser < 1 : 8 y puede persistir de por vida; este estado denominado "serorápido" puede dificultar la interpretación. (11) 4) Una madre que ha recibido un tratamiento adecuado para la sífilis durante el embarazo todavía puede transferir pasivamente anticuerpos al recién nacido, lo que da como resultado un título positivo en el lactante en ausencia de infección. En esta circunstancia, el título del recién nacido suele ser menor que el de la madre y vuelve a ser negativo después de varios meses.…”

Section: ¿Cuáles Son Las Limitaciones De Estas Pruebas?unclassified

Sífilis: las sombras en el diagnóstico. A propósito de un caso clínico.

2023

RUMI

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Syphilis: shadows in the diagnosis. Regarding a clinical case.Sífilis: sombras no diagnóstico. Relativo a um caso clínico.Resumen: La sífilis es una infección de transmisión sexual, potencialmente grave. La presentación clínica es muy variada, desde manifestaciones cutáneo-mucosas hasta neurológicas. Para el diagnóstico se emplean estudios de laboratorio, treponémicos y no treponémicos, con los que se realizan diferentes algoritmos para disminuir las limitaciones de cada prueba por separado. Se discute el caso de un joven que se presenta con fiebre y lesiones en piel sugestivas de sífilis secundaria, con un test VDRL falso negativo por efecto prozona. Este fenómeno, infrecuente, se debe a la concentración desproporcionadamente alta de anticuerpos. Conocer las herramientas diagnósticas y trabajar en conjunto con el equipo de laboratorio, puede facilitar el acercamiento a la enfermedad y a un tratamiento oportuno disminuyendo así la morbimortalidad de los pacientes.

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Section: ¿Cuáles Son Las Limitaciones De Estas Pruebas?unclassified

Sífilis: las sombras en el diagnóstico. A propósito de un caso clínico.

2023

RUMI

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“…Three episodes of gonococcal infections are associated with more than 50% risk of infertility,1 which can be devastating for young adults. As up to 70% of infections in women are asymptomatic,2 women may not be aware of the risk of long-term health effects. Gonococcal infection rates have been extremely high in remote regions of the Northern Territory (NT) and are increasing more generally in Australia,3 potentially contributing to an increase in pelvic inflammatory disease, infertility and disseminated gonococcal infection.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive observational study evaluating the enduring effectiveness of 4CMenB, the meningococcal B vaccine against gonococcal infections in the Northern Territory and South Australia, Australia: study protocol

Marshall,

Ward,

Wang

et al. 2024

BMJ Open

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IntroductionThe effectiveness of antibiotics for treating gonococcal infections is compromised due to escalating antibiotic resistance; and the development of an effective gonococcal vaccine has been challenging. Emerging evidence suggests that the licensed meningococcal B (MenB) vaccine, 4CMenB is effective against gonococcal infections due to cross-reacting antibodies and 95% genetic homology between the two bacteria,Neisseria meningitidisandNeisseria gonorrhoeae,that cause the diseases. This project aims to undertake epidemiological and genomic surveillance to evaluate the long-term protection of the 4CMenB vaccine against gonococcal infections in the Northern Territory (NT) and South Australia (SA), and to determine the potential benefit of a booster vaccine doses to provide longer-term protection against gonococcal infections.Methods and analysesThis observational study will provide long-term evaluation results of the effectiveness of the 4CMenB vaccine against gonococcal infections at 4–7 years post 4CMenB programme implementation. Routine notifiable disease notifications will be the basis for assessing the impact of the vaccine on gonococcal infections. Pathology laboratories will provide data on the number and percentage ofN. gonorrhoeaepositive tests relative to all tests administered and will coordinate molecular sequencing for isolates. Genome sequencing results will be provided by SA Pathology and Territory Pathology/New South Wales Health Pathology, and linked with notification data by SA Health and NT Health. There are limitations in observational studies including the potential for confounding. Confounders will be analysed separately for each outcome/comparison.Ethics and disseminationThe protocol and all study documents have been reviewed and approved by the SA Department for Health and Well-being Human Research Ethics Committee (HREC/2022/HRE00308), and the evaluation will commence in the NT on receipt of approval from the NT Health and Menzies School of Health Research Human Research Ethics Committee. Results will be published in peer-reviewed journals and presented at scientific meetings and public forums.

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Infectious Disorders of the Lower Genital Tract

Cited by 2 publications

References 217 publications

Sífilis: las sombras en el diagnóstico. A propósito de un caso clínico.

Sífilis: las sombras en el diagnóstico. A propósito de un caso clínico.

Comprehensive observational study evaluating the enduring effectiveness of 4CMenB, the meningococcal B vaccine against gonococcal infections in the Northern Territory and South Australia, Australia: study protocol

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