Infectious eccrine hidradenitis caused by nocardia

A Case of Neutrophilic Eccrine Hidradenitis Associated with Streptococcal Infectious Endocarditis

“…Our case was an otherwise healthy young man, and no medication was implicated in the onset of the cutaneous eruption. We therefore support the hypothesis that NEH is a cutaneous reaction to nonspecifi c stimuli, as suggested by Antonovich et al [16] . Fujisawa et al [17] pointed out that neutrophilic dermatosis may be a sign for underlying mycobacterium infection.…”

“…They include Osler's nodes, Janeway lesions, subungual splinter hemorrhages, cutaneous purpura and petechiae, and conjunctival petechiae (Roth's spots). Only 1 case of NEH associated with IE has been reported [16] . Although further observation and study of additional cases are needed to better understand the pathophysiological pathways of NEH, the current case suggests the importance of screening NEH patients for cardiac disorders, especially in those without a causative drug history.…”

Reações tegumentares adversas relacionadas aos agentes antineoplásicos: parte I

“…1,23,24 been associated with HIV infection, Nocardia, Serratia, Enterobacter, Staphylococcus, and with patients receiving granulocyte colony-stimulating factor (G-CSF). 1,25,26 The mechanism is unknown, but it may be due to the excretion of the chemotherapeutic drug by the eccrine glands and its direct toxic effect on the eccrine epithelium. 25,26 The clinical condition may be preceded by fever and unspecific clinical signs.…”

“…1,25,26 The mechanism is unknown, but it may be due to the excretion of the chemotherapeutic drug by the eccrine glands and its direct toxic effect on the eccrine epithelium. 25,26 The clinical condition may be preceded by fever and unspecific clinical signs. 24,25 Skin eruptions are distributed in the head, neck, trunk, and extremities, with lesions that vary from erythema, papules, nodules, and pustules to papular plaques.…”

“…They appear between 2 days and 3 weeks from the start of treatment, regressing spontaneously without scarring or sequelae 1 to 4 weeks after the suspension of the drug. [24][25][26][27][28] The differential diagnosis is vast and includes: sepsis, septic embolism in a post-chemotherapeutic neutropenic patient, vasculitis, leukemia cutis, hypersensitivity reaction, urticaria, polymorphous erythema, and neutrophilic dermatoses such as Sweet's syndrome, bullous pyoderma gangrenosum and atypical pyoderma gangrenosum. 18,28,29 Due to the unspecific clinical presentation of the disease and the great number of differential diagnoses, some authors suggest that NEH be included in the diagnostic hypotheses of any eruption that may occur in patients undergoing chemotherapy, and its final diagnosis is established via histopathology.…”