Infectious flare-ups and serious sequelae following endodontic treatment: A prospective randomized trial on efficacy of antibiotic prophylaxis in cases of asymptomatic pulpal-periapical lesions

Incidence and factors related to flare‐ups in a graduate endodontic programme

“…Other factors previously reported as predictors of flareup, such as pre-operative pain (Torabinejad & Kettering (Morse et al 1987, Rimmer 1991) and analgesics (Torabinejad & Kettering 1988, Walton & Fouad 1992 did not reveal any relationship to flare-up in the study group. When all factors thought to affect flare-ups are considered simultaneously, it becomes apparent why there is little consistency between the earlier studies.…”

Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait

“…20 -22 There is also no rationale for routine use of antibiotics, when root-filling asymptomatic teeth with pulpal necrosis and associated periapical lesions. 19,23 Similarly, uncomplicated apicectomies do not require antibiotics cover. Therefore, antibiotics prophylaxis in the majority of minor oral surgery cases is unnecessary.…”

Systemic Antibiotics in Endodontic Practice: Mandatory Or, Optional

“…Antibiotics became popular since there was rapid recovery of wounded military personnel during the war. The first use of antibiotics in endodontics was introduced in the year 1951 by Grossman as a poly-antibiotic paste known as PBSC (Mixture of penicillin, bacitracin, streptomycin and caprylate sodium) with penicillin being effective against the gram positive organisms, bacitracin against the 8,9 Antibiotics have, also, been used during regenerative procedures for disinfection of the root canal. The most commonly used antibiotic is Triple Antibiotic Paste containing metronidazole, ciplofloxacin and minocycline in the ratio 1:1:1.…”