Infectious Hepatitis: A 3-Year Retrospective Study at a Tertiary Care Hospital in India

Samaddar, Arghadip; Taklikar, Shripad; Kale, Pradnya; Kumar, Chaya A.; Baveja, Sujata

doi:10.4103/ijmm.ijmm_19_197

Cited by 14 publications

(13 citation statements)

References 15 publications

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“…Infection with HAV causes an immune response which is assessed by measurement of specific antibodies: immunoglobulin class M (IgM) anti-HAV antibodies and immunoglobin class G (IgG) anti-HAV antibodies and detected during acute illness when the serum aminotransferase levels are elevated and there is fecal shedding of the virus. Anti-HAV IgM antibodies can be detected after acute infection and antibodies often disappear up to 6 months, while Anti-HAV IgG antibodies present within 2 to 3 months after the onset of the disease and protect against infections by providing life-long immunity [ 5 , 6 ]. Most studies on seroprevalence data of hepatitis A virus are usually reported as anti-HAV IgG, rather than anti-HAV IgM seroprevalence data [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of acute liver failure associated with hepatitis A infection in children in Mogadishu, Somalia: a hospital-based retrospective study

et al. 2021

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Background Hepatitis A is one of the most common infectious causes of acute hepatitis, and currently, a neglected global public health problem necessitating an urgent response in Somalia. Hepatitis A infection and its rare complication of acute liver failure in children are largely based on very limited data. The aim of the study was therefore to investigate the Hepatitis A infection and its rare complication of acute liver failure in children in Somalia. Methods This retrospective study was conducted on children aged 0–18 years who were admitted to the pediatric departments of the Somalia Mogadishu-Turkey Training and Research Hospital, Somali, from June 2019 and December 2019. Patients who were tested for hepatitis A infection during the study period and had complete data were included. Children with chronic disease, primary or secondary immunodeficiency, blood transfusion history, and missing data were excluded. Abstracted data including patients' demographics, clinical presentation, laboratory results, ultrasonographic findings, length of hospital stay, clinical course and outcome were retrieved from the hospital database system. Results Of the 13,047 children, 219 were analyzed. Of the 219 Hepatitis A cases, 25 (11%) were diagnosed with pediatric acute liver failure (PALF). The mean age of children with Hepatitis A was 6.7 years. The majority of cases were reported in the 5–9 (39.7%) year age range. Hepatic encephalopathy, length of hospital stay, levels of albumin, and values of PT, aPPT, and INR were significantly higher in children with acute live failure. The presence of cholecystitis and cholecystitis with ascites in the sonographic evaluation were poor prognostic markers for acute liver failure. Conclusions This study revealed hepatitis A virus infection and its related acute liver failure among hospitalized children in Somalia of which 11% had PALF. Hence, the introduction of Hepatitis A vaccination, which is the main public health tool, into the national immunization program, the improvement of hygiene conditions, raising awareness of the disease, and increasing health literacy are necessary to prevent the consequence of the Hepatitis A virus in children.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics of acute liver failure associated with hepatitis A infection in children in Mogadishu, Somalia: a hospital-based retrospective study

et al. 2021

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“…El comportamiento de los casos de hepatitis en el período, fue mayor a inicios de año en los meses de enero (170 casos) y febrero (169 casos), época de invierno, con un repunte en el mes de agosto (125 casos) época de verano, que concuerda con el estudio realizado en Cuba, provincia de Ciego de Ávila, durante los años 1997-2008, cuyo objetivo fue evaluar la estacionalidad de la HVA, con un universo de 3516 casos, provenientes de 10 municipios, la mayor frecuencia de la endemia ocurrió en los meses de febrero, agosto y noviembre (Posada Fernández et al, 2011). Muchos otros estudios también evidencian que la incidencia es mayor en los meses de invierno y verano (Moon et al, 2016;Samaddar et al, 2019).…”

Section: Discussionunclassified

“…El virus de la hepatitis A, se trasmite por vía oral-fecal-oral de forma directa o a través de alimentos o agua contaminada, es más frecuente la incidencia en poblaciones con deficiencias hidrosanitarias, pobres y que no cumplen con las medidas adecuadas de prevención personal; afecta más a los niños quienes pueden padecer la enfermedad en forma asintomática (Barnett & Herrera, 2007;Samaddar et al, 2019;Tarek et al, 2019).…”

Section: Introductionunclassified

Distribución Temporo Espacial De La Hepatitis Viral Tipo A, en La Zona 7 Del Ecuador

Bermeo-Flores¹,

Tapia²,

González-Merizalde³

et al. 2022

JHS

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“…Awareness of the clinical symptoms of acute viral hepatitis is also important for the early identification and seeking of medical attention so as to prevent morbidity and mortality related to the disease [13]. The public health sectors need to work in collaboration to increase public awareness, facilitate timely preparation and make necessary arrangements to counter outbreaks or epidemics and thus reduce morbidity, mortality and economic burden [14].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Acute Viral Hepatitis in Symptomatic Patients in a Tertiary Care Hospital of North India

Maasha

Oberoi²,

Sidhu³

et al. 2022

JAMB

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Background: Acute Viral Hepatitis (AVH) is a major health problem worldwide, with a higher incidence in developing countries, like India. The most common cause of viral hepatitis is a specific group of hepatic viruses A, B, C and E (HAV, HBV, HCV and HEV). Their clinical manifestations range from asymptomatic to acute and fulminant hepatitis or chronic hepatitis. Exploring the etiological spectrum and clinic-epidemiological profile of AVH becomes essential for formulating the preventive measures to control the disease. The aim of the present study was to determine the prevalence of Hepatitis A virus (HAV), Hepatitis B virus (HBV), Hepatitis C virus (HCV) and Hepatitis E virus (HEV) as causes of AVH in a tertiary care hospital of North India. Materials and Methods: A retrospective study was conducted on 122 patients with clinical signs and symptoms of acute viral hepatitis during May 2021 to April 2022. Serum was separated and tested for IgM anti-HAV antibodies, IgM anti-HEV antibodies, Hepatitis B surface antigen (HbsAg) and IgM anti-HCV antibodies by Enzyme Linked Immunosorbent Assay (ELISA). Results: Out of 122 AVH patients, HAV (41.80%) was identified as the most common cause of acute hepatitis followed by HEV (36.88%), HBV (17.21%) and HCV (13.11%). Co-infections with more than one virus were present in 28 cases; HAV-HEV co-infection being the most common. Amongst the positive AVH cases, the seropositivity was higher in males (60.65%) than females (39.34%). The most common symptom was Icterus (64.87%), followed by fever (52.51%), pain abdomen (50.91%), anorexia (46.22%), vomiting (26.24%), malaise (21.24%) and diarrhea (12.23%). Conclusion: In our present study we have found that HAV is the most common cause of acute viral hepatitis followed by HEV, HBV and HCV with icterus being the most common symptom followed by fever, pain abdomen, anorexia, vomiting, malaise and diarrhea. Regular diagnosis of AVH and monitoring of cases will help in patient management and thus reduce morbidity and mortality.

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Infectious Hepatitis: A 3-Year Retrospective Study at a Tertiary Care Hospital in India

Cited by 14 publications

References 15 publications

Clinical characteristics of acute liver failure associated with hepatitis A infection in children in Mogadishu, Somalia: a hospital-based retrospective study

Clinical characteristics of acute liver failure associated with hepatitis A infection in children in Mogadishu, Somalia: a hospital-based retrospective study

Distribución Temporo Espacial De La Hepatitis Viral Tipo A, en La Zona 7 Del Ecuador

Prevalence of Acute Viral Hepatitis in Symptomatic Patients in a Tertiary Care Hospital of North India

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