Infectious long non-coding RNAs

Κατσαρού, Κωνσταντίνα; Rao, A. L. N.; Tsagris, Mina; Kalantidis, Kriton

doi:10.1016/j.biochi.2015.05.005

Cited by 30 publications

(30 citation statements)

References 164 publications

(123 reference statements)

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“…Viroids are non-coding RNA pathogens with unencapsidated, circular RNA genomes (reviewed by [ 1 ]) which are relatively short (246–467 nt), and which cause plant diseases of important crops including tomato and potato [ 2 ]. Viroids were reported and described first in 1970’s in the spindle tuber disease of potato [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Insight on Genes Affecting Tuber Development in Potato upon Potato spindle tuber viroid (PSTVd) Infection

Κατσαρού

Zhang

et al. 2016

PLoS ONE

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Potato (Solanum tuberosum L) is a natural host of Potato spindle tuber viroid (PSTVd) which can cause characteristic symptoms on developing plants including stunting phenotype and distortion of leaves and tubers. PSTVd is the type species of the family Pospiviroidae, and can replicate in the nucleus and move systemically throughout the plant. It is not well understood how the viroid can affect host genes for successful invasion and which genes show altered expression levels upon infection. Our primary focus in this study is the identification of genes which can affect tuber formation since viroid infection can strongly influence tuber development and especially tuber shape. In this study, we used a large-scale method to identify differentially expressed genes in potato. We have identified defence, stress and sugar metabolism related genes having altered expression levels upon infection. Additionally, hormone pathway related genes showed significant up- or down-regulation. DWARF1/DIMINUTO, Gibberellin 7-oxidase and BEL5 transcripts were identified and validated showing differential expression in viroid infected tissues. Our study suggests that gibberellin and brassinosteroid pathways have a possible role in tuber development upon PSTVd infection.

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Section: Introductionmentioning

confidence: 99%

Insight on Genes Affecting Tuber Development in Potato upon Potato spindle tuber viroid (PSTVd) Infection

Κατσαρού

Zhang

et al. 2016

PLoS ONE

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“…In summary, the data reported herein reveal that HSVd is able to recruit and subvert host HDA6 during infection, providing novel evidence regarding the potential of viroids to redesign the host cell environment and reprogram host regulatory mechanisms to ensure that their infectious cycle can be fulfilled. Furthermore, this study provides additional support to the emerging idea that the study of viroids as regulatory elements capable of altering host cell homeostasis can contribute to interpret the poorly understood pan‐regulatory pathways directed by lncRNAs in plants (Ding, ; Gomez & Pallas, ; Katsarou et al ., ; Liu et al ., ; Gago‐Zachert, ).…”

Section: Discussionmentioning

confidence: 99%

A pathogenic long noncoding RNA redesigns the epigenetic landscape of the infected cells by subverting host Histone Deacetylase 6 activity

2016

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SummaryViroids -ancient plant-pathogenic long noncoding RNAs -have developed a singular evolutionary strategy based on reprogramming specific phases of host-metabolism to ensure that their infection cycle can be completed in infected cells. However, the molecular aspects governing this transregulatory phenomenon remain elusive.Here, we use immunoprecipitation assays and bisulfite sequencing of rDNA to shown that, in infected cucumber and Nicotiana benthamina plants, Hop stunt viroid (HSVd) recruits and functionally subverts Histone Deacetylase 6 (HDA6) to promote host-epigenetic alterations that trigger the transcriptional alterations observed during viroid pathogenesis.This notion is supported by the demonstration that, during infection, the HSVd-HDA6 complex occurs in vivo and that endogenous HDA6 expression is increased in HSVd-infected cells. Moreover, transient overexpression of recombinant HDA6 reverts the hypomethylation status of rDNA observed in HSVd-infected plants and reduces viroid accumulation. We hypothesize that the host-transcriptional alterations induced as a consequence of viroid-mediated HDA6 recruitment favor spurious recognition of HSVd-RNA as an RNA Pol II template, thereby improving viroid replication.Our results constitute the first description of a physical and functional interaction between a pathogenic RNA and a component of the host RNA silencing mechanism, providing novel evidence of the potential of these pathogenic lncRNAs to physically redesign the host-cell environment and reprogram their regulatory mechanisms.

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“…Genetic evidence suggests that genomic regions for numerous lncRNAs such as IGF2-AS and lncRNA MEG3 are associated with the susceptibility for diabetes 57, 58. In addition, a group of pathogen-derived long non-coding RNAs, namely, infectious lncRNAs are expected to be engaged in infection processes 59 . Furthermore, genome-wide association studies have revealed the linkage between various single nucleotide polymorphisms (SNPs) and autoimmune or immune-related diseases 60 .…”

Section: Lncrna and Immune-related Diseasesmentioning

confidence: 99%

Functional diversity of long non-coding RNAs in immune regulation

Geng

Tan

2016

Genes & Diseases

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Precise and dynamic regulation of gene expression is a key feature of immunity. In recent years, rapid advances in transcriptome profiling analysis have led to recognize long non-coding RNAs (lncRNAs) as an additional layer of gene regulation context. In the immune system, lncRNAs are found to be widely expressed in immune cells including monocytes, macrophages, dendritic cells (DC), neutrophils, T cells and B cells during their development, differentiation and activation. However, the functional importance of immune-related lncRNAs is just emerging to be characterized. In this review, we discuss the up-to-date knowledge of lncRNAs in immune regulation.

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Infectious long non-coding RNAs

Cited by 30 publications

References 164 publications

Insight on Genes Affecting Tuber Development in Potato upon Potato spindle tuber viroid (PSTVd) Infection

Insight on Genes Affecting Tuber Development in Potato upon Potato spindle tuber viroid (PSTVd) Infection

A pathogenic long noncoding RNA redesigns the epigenetic landscape of the infected cells by subverting host Histone Deacetylase 6 activity

Functional diversity of long non-coding RNAs in immune regulation

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